Vitamin A supplementation improves retinal function in infants at risk of retinopathy of prematurity

Helen Mactier; Daphne McCulloch; Ruth Hamilton; Peter Galloway; Michael S. Bradnam; David Young; Timothy Lavy; Lesley Farrell; Lawrence T. Weaver

doi:10.1016/j.jpeds.2011.12.013

Vitamin A supplementation improves retinal function in infants at risk of retinopathy of prematurity

Helen Mactier, Daphne McCulloch, Ruth Hamilton, Peter Galloway, Michael S. Bradnam, David Young, Timothy Lavy, Lesley Farrell, Lawrence T. Weaver

Vision Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Preterm infants show reduced retinal sensitivity at term corrected age compared with newborn term infants. We tested the hypothesis that retinal sensitivity in preterm infants is improved by early, high-dose vitamin A. We report a double-blind, randomized controlled trial of infants <32 weeks’ gestation and/or <1501 g birth weight. Supplemented infants received additional intramuscular vitamin A 10 000 IU 3 times weekly from day 2 for a minimum of 2 weeks or until establishment of oral feeding. Hepatic stores were assessed by relative dose response (RDR). The primary outcome measure was cone-corrected dark-adapted retinal rod sensitivity measured by electroretinogram at 36 weeks’ postmenstrual age (PMA).

Original language	English
Pages (from-to)	954-959
Number of pages	6
Journal	Journal of Pediatrics
Volume	160
Issue number	6
DOIs	https://doi.org/10.1016/j.jpeds.2011.12.013
Publication status	Published - Jun 2012

Keywords

vision sciences
retinopathy

Documents and Links

10.1016/j.jpeds.2011.12.013

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title = "Vitamin A supplementation improves retinal function in infants at risk of retinopathy of prematurity",

abstract = "Preterm infants show reduced retinal sensitivity at term corrected age compared with newborn term infants. We tested the hypothesis that retinal sensitivity in preterm infants is improved by early, high-dose vitamin A. We report a double-blind, randomized controlled trial of infants <32 weeks{\textquoteright} gestation and/or <1501 g birth weight. Supplemented infants received additional intramuscular vitamin A 10 000 IU 3 times weekly from day 2 for a minimum of 2 weeks or until establishment of oral feeding. Hepatic stores were assessed by relative dose response (RDR). The primary outcome measure was cone-corrected dark-adapted retinal rod sensitivity measured by electroretinogram at 36 weeks{\textquoteright} postmenstrual age (PMA).",

keywords = "vision sciences, retinopathy",

author = "Helen Mactier and Daphne McCulloch and Ruth Hamilton and Peter Galloway and Bradnam, {Michael S.} and David Young and Timothy Lavy and Lesley Farrell and Weaver, {Lawrence T.}",

year = "2012",

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doi = "10.1016/j.jpeds.2011.12.013",

language = "English",

volume = "160",

pages = "954--959",

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Vitamin A supplementation improves retinal function in infants at risk of retinopathy of prematurity. / Mactier, Helen; McCulloch, Daphne; Hamilton, Ruth; Galloway, Peter; Bradnam, Michael S.; Young, David; Lavy, Timothy; Farrell, Lesley; Weaver, Lawrence T.

In: Journal of Pediatrics, Vol. 160, No. 6, 06.2012, p. 954-959.

Research output: Contribution to journal › Article › peer-review

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AU - Mactier, Helen

AU - McCulloch, Daphne

AU - Hamilton, Ruth

AU - Galloway, Peter

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AU - Young, David

AU - Lavy, Timothy

AU - Farrell, Lesley

AU - Weaver, Lawrence T.

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AB - Preterm infants show reduced retinal sensitivity at term corrected age compared with newborn term infants. We tested the hypothesis that retinal sensitivity in preterm infants is improved by early, high-dose vitamin A. We report a double-blind, randomized controlled trial of infants <32 weeks’ gestation and/or <1501 g birth weight. Supplemented infants received additional intramuscular vitamin A 10 000 IU 3 times weekly from day 2 for a minimum of 2 weeks or until establishment of oral feeding. Hepatic stores were assessed by relative dose response (RDR). The primary outcome measure was cone-corrected dark-adapted retinal rod sensitivity measured by electroretinogram at 36 weeks’ postmenstrual age (PMA).

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