Vitamin A supplementation improves retinal function in infants at risk of retinopathy of prematurity

Helen Mactier, Daphne McCulloch, Ruth Hamilton, Peter Galloway, Michael S. Bradnam, David Young, Timothy Lavy, Lesley Farrell, Lawrence T. Weaver

Research output: Contribution to journalArticlepeer-review

Abstract

Preterm infants show reduced retinal sensitivity at term corrected age compared with newborn term infants. We tested the hypothesis that retinal sensitivity in preterm infants is improved by early, high-dose vitamin A. We report a double-blind, randomized controlled trial of infants <32 weeks’ gestation and/or <1501 g birth weight. Supplemented infants received additional intramuscular vitamin A 10 000 IU 3 times weekly from day 2 for a minimum of 2 weeks or until establishment of oral feeding. Hepatic stores were assessed by relative dose response (RDR). The primary outcome measure was cone-corrected dark-adapted retinal rod sensitivity measured by electroretinogram at 36 weeks’ postmenstrual age (PMA).
Original languageEnglish
Pages (from-to)954-959
Number of pages6
JournalJournal of Pediatrics
Volume160
Issue number6
DOIs
Publication statusPublished - Jun 2012

Keywords

  • vision sciences
  • retinopathy

Fingerprint

Dive into the research topics of 'Vitamin A supplementation improves retinal function in infants at risk of retinopathy of prematurity'. Together they form a unique fingerprint.

Cite this