Visual Function Questionnaire as an outcome measure for homonymous hemianopia: subscales and supplementary questions, analysis from the VISION trial

Fiona J Rowe, Lauren R Hepworth, Elizabeth J Conroy, Naomi EA Rainford, Emma Bedson, Avril Drummond, Marta Garcia-Finana, Claire Howard, Alex Pollock, Tracey Shipman, Caroline Dodridge, Stevie Johnson, Carmel Noonan, Catherine Sackley

Research output: Contribution to journalArticle

Abstract

Background:: We conduct supplementary analyses of the NEI VFQ-25 data to evaluate where changes occurred within subscales of the NEI VFQ-25 leading to change in the composite scores between the three treatment arms, and evaluate the NEI VFQ-25 with and without the Neuro 10 supplement. Methods:: A prospective, multicentre, parallel, single-blind, three-arm RCT of fourteen UK acute stroke units was conducted. Stroke survivors with homonymous hemianopia were recruited. Interventions included: Fresnel prisms for minimum 2 h, 5 days/week over 6-weeks (Arm a), Visual search training for minimum 30 min, 5 days/week over 6-weeks (Arm b) and standard care-information only (Arm c). Primary and secondary outcomes (including NEI VFQ-25 data) were measured at baseline, 6, 12 and 26 weeks after randomisation. Results:: Eighty seven patients were recruited (69% male; mean age (SD) equal to 69 (12) years). At 26 weeks, outcomes for 24, 24 and 22 patients, respectively, were compared to baseline. NEI VFQ-25 (with and without Neuro 10) responses improved from baseline to 26 weeks with visual search training compared to Fresnel prisms and standard care. In subscale analysis, the most impacted across all treatment arms was ‘driving’ whilst the least impacted were ‘colour vision’ and ‘ocular pain’. Conclusions:: Composite scores differed systematically for the NEI VFQ-25 (Neuro 10) versus NEI VFQ-25 at all time points. For subscale scores, descriptive statistics suggest clinically relevant improvement in distance activities and vision-specific dependency subscales for NEI VFQ-25 scores in the visual search treatment arm. Trial Registration: Current Controlled Trials ISRCTN05956042.
Original languageEnglish
JournalEye
Volume33
DOIs
Publication statusPublished - 17 Apr 2019

Fingerprint

Hemianopsia
Outcome Assessment (Health Care)
Eye Pain
Stroke
Color Vision
Random Allocation
Survivors
Therapeutics
Surveys and Questionnaires

Keywords

  • homonymous hemianopia
  • pilot trial
  • prism therapy
  • randomised controlled trial
  • standard care
  • stroke
  • visual search training
  • Visual Function Questionnaire-25
  • quality of life

Cite this

Rowe, Fiona J ; Hepworth, Lauren R ; Conroy, Elizabeth J ; Rainford, Naomi EA ; Bedson, Emma ; Drummond, Avril ; Garcia-Finana, Marta ; Howard, Claire ; Pollock, Alex ; Shipman, Tracey ; Dodridge, Caroline ; Johnson, Stevie ; Noonan, Carmel ; Sackley, Catherine. / Visual Function Questionnaire as an outcome measure for homonymous hemianopia: subscales and supplementary questions, analysis from the VISION trial. In: Eye. 2019 ; Vol. 33.
@article{9c9779ccc5a643e0b2e251dc949954b0,
title = "Visual Function Questionnaire as an outcome measure for homonymous hemianopia: subscales and supplementary questions, analysis from the VISION trial",
abstract = "Background:: We conduct supplementary analyses of the NEI VFQ-25 data to evaluate where changes occurred within subscales of the NEI VFQ-25 leading to change in the composite scores between the three treatment arms, and evaluate the NEI VFQ-25 with and without the Neuro 10 supplement. Methods:: A prospective, multicentre, parallel, single-blind, three-arm RCT of fourteen UK acute stroke units was conducted. Stroke survivors with homonymous hemianopia were recruited. Interventions included: Fresnel prisms for minimum 2 h, 5 days/week over 6-weeks (Arm a), Visual search training for minimum 30 min, 5 days/week over 6-weeks (Arm b) and standard care-information only (Arm c). Primary and secondary outcomes (including NEI VFQ-25 data) were measured at baseline, 6, 12 and 26 weeks after randomisation. Results:: Eighty seven patients were recruited (69{\%} male; mean age (SD) equal to 69 (12) years). At 26 weeks, outcomes for 24, 24 and 22 patients, respectively, were compared to baseline. NEI VFQ-25 (with and without Neuro 10) responses improved from baseline to 26 weeks with visual search training compared to Fresnel prisms and standard care. In subscale analysis, the most impacted across all treatment arms was ‘driving’ whilst the least impacted were ‘colour vision’ and ‘ocular pain’. Conclusions:: Composite scores differed systematically for the NEI VFQ-25 (Neuro 10) versus NEI VFQ-25 at all time points. For subscale scores, descriptive statistics suggest clinically relevant improvement in distance activities and vision-specific dependency subscales for NEI VFQ-25 scores in the visual search treatment arm. Trial Registration: Current Controlled Trials ISRCTN05956042.",
keywords = "homonymous hemianopia, pilot trial, prism therapy, randomised controlled trial, standard care, stroke, visual search training, Visual Function Questionnaire-25, quality of life",
author = "Rowe, {Fiona J} and Hepworth, {Lauren R} and Conroy, {Elizabeth J} and Rainford, {Naomi EA} and Emma Bedson and Avril Drummond and Marta Garcia-Finana and Claire Howard and Alex Pollock and Tracey Shipman and Caroline Dodridge and Stevie Johnson and Carmel Noonan and Catherine Sackley",
note = "Acceptance in SAN File set to Closed in error (checked author emails, all ok). Now updated. ET 29/10/19",
year = "2019",
month = "4",
day = "17",
doi = "10.1038/s41433-019-0441-z",
language = "English",
volume = "33",
journal = "Eye",
issn = "0950-222X",
publisher = "Nature Publishing Group",

}

Rowe, FJ, Hepworth, LR, Conroy, EJ, Rainford, NEA, Bedson, E, Drummond, A, Garcia-Finana, M, Howard, C, Pollock, A, Shipman, T, Dodridge, C, Johnson, S, Noonan, C & Sackley, C 2019, 'Visual Function Questionnaire as an outcome measure for homonymous hemianopia: subscales and supplementary questions, analysis from the VISION trial', Eye, vol. 33. https://doi.org/10.1038/s41433-019-0441-z

Visual Function Questionnaire as an outcome measure for homonymous hemianopia: subscales and supplementary questions, analysis from the VISION trial. / Rowe, Fiona J; Hepworth, Lauren R; Conroy, Elizabeth J; Rainford, Naomi EA; Bedson, Emma; Drummond, Avril; Garcia-Finana, Marta; Howard, Claire; Pollock, Alex; Shipman, Tracey; Dodridge, Caroline; Johnson, Stevie; Noonan, Carmel; Sackley, Catherine.

In: Eye, Vol. 33, 17.04.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Visual Function Questionnaire as an outcome measure for homonymous hemianopia: subscales and supplementary questions, analysis from the VISION trial

AU - Rowe, Fiona J

AU - Hepworth, Lauren R

AU - Conroy, Elizabeth J

AU - Rainford, Naomi EA

AU - Bedson, Emma

AU - Drummond, Avril

AU - Garcia-Finana, Marta

AU - Howard, Claire

AU - Pollock, Alex

AU - Shipman, Tracey

AU - Dodridge, Caroline

AU - Johnson, Stevie

AU - Noonan, Carmel

AU - Sackley, Catherine

N1 - Acceptance in SAN File set to Closed in error (checked author emails, all ok). Now updated. ET 29/10/19

PY - 2019/4/17

Y1 - 2019/4/17

N2 - Background:: We conduct supplementary analyses of the NEI VFQ-25 data to evaluate where changes occurred within subscales of the NEI VFQ-25 leading to change in the composite scores between the three treatment arms, and evaluate the NEI VFQ-25 with and without the Neuro 10 supplement. Methods:: A prospective, multicentre, parallel, single-blind, three-arm RCT of fourteen UK acute stroke units was conducted. Stroke survivors with homonymous hemianopia were recruited. Interventions included: Fresnel prisms for minimum 2 h, 5 days/week over 6-weeks (Arm a), Visual search training for minimum 30 min, 5 days/week over 6-weeks (Arm b) and standard care-information only (Arm c). Primary and secondary outcomes (including NEI VFQ-25 data) were measured at baseline, 6, 12 and 26 weeks after randomisation. Results:: Eighty seven patients were recruited (69% male; mean age (SD) equal to 69 (12) years). At 26 weeks, outcomes for 24, 24 and 22 patients, respectively, were compared to baseline. NEI VFQ-25 (with and without Neuro 10) responses improved from baseline to 26 weeks with visual search training compared to Fresnel prisms and standard care. In subscale analysis, the most impacted across all treatment arms was ‘driving’ whilst the least impacted were ‘colour vision’ and ‘ocular pain’. Conclusions:: Composite scores differed systematically for the NEI VFQ-25 (Neuro 10) versus NEI VFQ-25 at all time points. For subscale scores, descriptive statistics suggest clinically relevant improvement in distance activities and vision-specific dependency subscales for NEI VFQ-25 scores in the visual search treatment arm. Trial Registration: Current Controlled Trials ISRCTN05956042.

AB - Background:: We conduct supplementary analyses of the NEI VFQ-25 data to evaluate where changes occurred within subscales of the NEI VFQ-25 leading to change in the composite scores between the three treatment arms, and evaluate the NEI VFQ-25 with and without the Neuro 10 supplement. Methods:: A prospective, multicentre, parallel, single-blind, three-arm RCT of fourteen UK acute stroke units was conducted. Stroke survivors with homonymous hemianopia were recruited. Interventions included: Fresnel prisms for minimum 2 h, 5 days/week over 6-weeks (Arm a), Visual search training for minimum 30 min, 5 days/week over 6-weeks (Arm b) and standard care-information only (Arm c). Primary and secondary outcomes (including NEI VFQ-25 data) were measured at baseline, 6, 12 and 26 weeks after randomisation. Results:: Eighty seven patients were recruited (69% male; mean age (SD) equal to 69 (12) years). At 26 weeks, outcomes for 24, 24 and 22 patients, respectively, were compared to baseline. NEI VFQ-25 (with and without Neuro 10) responses improved from baseline to 26 weeks with visual search training compared to Fresnel prisms and standard care. In subscale analysis, the most impacted across all treatment arms was ‘driving’ whilst the least impacted were ‘colour vision’ and ‘ocular pain’. Conclusions:: Composite scores differed systematically for the NEI VFQ-25 (Neuro 10) versus NEI VFQ-25 at all time points. For subscale scores, descriptive statistics suggest clinically relevant improvement in distance activities and vision-specific dependency subscales for NEI VFQ-25 scores in the visual search treatment arm. Trial Registration: Current Controlled Trials ISRCTN05956042.

KW - homonymous hemianopia

KW - pilot trial

KW - prism therapy

KW - randomised controlled trial

KW - standard care

KW - stroke

KW - visual search training

KW - Visual Function Questionnaire-25

KW - quality of life

U2 - 10.1038/s41433-019-0441-z

DO - 10.1038/s41433-019-0441-z

M3 - Article

VL - 33

JO - Eye

JF - Eye

SN - 0950-222X

ER -