Visual Function Questionnaire as an outcome measure for homonymous hemianopia: subscales and supplementary questions, analysis from the VISION trial

Fiona J Rowe*, Lauren R Hepworth, Elizabeth J Conroy, Naomi EA Rainford, Emma Bedson, Avril Drummond, Marta Garcia-Finana, Claire Howard, Alex Pollock, Tracey Shipman, Caroline Dodridge, Stevie Johnson, Carmel Noonan, Catherine Sackley

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)
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Background:: We conduct supplementary analyses of the NEI VFQ-25 data to evaluate where changes occurred within subscales of the NEI VFQ-25 leading to change in the composite scores between the three treatment arms, and evaluate the NEI VFQ-25 with and without the Neuro 10 supplement. Methods:: A prospective, multicentre, parallel, single-blind, three-arm RCT of fourteen UK acute stroke units was conducted. Stroke survivors with homonymous hemianopia were recruited. Interventions included: Fresnel prisms for minimum 2 h, 5 days/week over 6-weeks (Arm a), Visual search training for minimum 30 min, 5 days/week over 6-weeks (Arm b) and standard care-information only (Arm c). Primary and secondary outcomes (including NEI VFQ-25 data) were measured at baseline, 6, 12 and 26 weeks after randomisation. Results:: Eighty seven patients were recruited (69% male; mean age (SD) equal to 69 (12) years). At 26 weeks, outcomes for 24, 24 and 22 patients, respectively, were compared to baseline. NEI VFQ-25 (with and without Neuro 10) responses improved from baseline to 26 weeks with visual search training compared to Fresnel prisms and standard care. In subscale analysis, the most impacted across all treatment arms was ‘driving’ whilst the least impacted were ‘colour vision’ and ‘ocular pain’. Conclusions:: Composite scores differed systematically for the NEI VFQ-25 (Neuro 10) versus NEI VFQ-25 at all time points. For subscale scores, descriptive statistics suggest clinically relevant improvement in distance activities and vision-specific dependency subscales for NEI VFQ-25 scores in the visual search treatment arm. Trial Registration: Current Controlled Trials ISRCTN05956042.
Original languageEnglish
Pages (from-to)1485-1493
Number of pages9
Early online date17 Apr 2019
Publication statusPublished - Sept 2019


  • homonymous hemianopia
  • pilot trial
  • prism therapy
  • randomised controlled trial
  • standard care
  • stroke
  • visual search training
  • Visual Function Questionnaire-25
  • quality of life
  • Single-Blind Method
  • Prospective Studies
  • Sickness Impact Profile
  • Hemianopsia/physiopathology
  • Humans
  • Middle Aged
  • Stroke/physiopathology
  • Male
  • Visual Acuity/physiology
  • Visual Fields/physiology
  • Quality of Life
  • Female
  • Surveys and Questionnaires
  • Aged
  • Outcome Assessment, Health Care

ASJC Scopus subject areas

  • Sensory Systems
  • Ophthalmology


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