TY - JOUR
T1 - Visual Function Questionnaire as an outcome measure for homonymous hemianopia: subscales and supplementary questions, analysis from the VISION trial
AU - Rowe, Fiona J
AU - Hepworth, Lauren R
AU - Conroy, Elizabeth J
AU - Rainford, Naomi EA
AU - Bedson, Emma
AU - Drummond, Avril
AU - Garcia-Finana, Marta
AU - Howard, Claire
AU - Pollock, Alex
AU - Shipman, Tracey
AU - Dodridge, Caroline
AU - Johnson, Stevie
AU - Noonan, Carmel
AU - Sackley, Catherine
N1 - Acceptance in SAN
File set to Closed in error (checked author emails, all ok). Now updated. ET 29/10/19
PY - 2019/9
Y1 - 2019/9
N2 - Background:: We conduct supplementary analyses of the NEI VFQ-25 data to evaluate where changes occurred within subscales of the NEI VFQ-25 leading to change in the composite scores between the three treatment arms, and evaluate the NEI VFQ-25 with and without the Neuro 10 supplement. Methods:: A prospective, multicentre, parallel, single-blind, three-arm RCT of fourteen UK acute stroke units was conducted. Stroke survivors with homonymous hemianopia were recruited. Interventions included: Fresnel prisms for minimum 2 h, 5 days/week over 6-weeks (Arm a), Visual search training for minimum 30 min, 5 days/week over 6-weeks (Arm b) and standard care-information only (Arm c). Primary and secondary outcomes (including NEI VFQ-25 data) were measured at baseline, 6, 12 and 26 weeks after randomisation. Results:: Eighty seven patients were recruited (69% male; mean age (SD) equal to 69 (12) years). At 26 weeks, outcomes for 24, 24 and 22 patients, respectively, were compared to baseline. NEI VFQ-25 (with and without Neuro 10) responses improved from baseline to 26 weeks with visual search training compared to Fresnel prisms and standard care. In subscale analysis, the most impacted across all treatment arms was ‘driving’ whilst the least impacted were ‘colour vision’ and ‘ocular pain’. Conclusions:: Composite scores differed systematically for the NEI VFQ-25 (Neuro 10) versus NEI VFQ-25 at all time points. For subscale scores, descriptive statistics suggest clinically relevant improvement in distance activities and vision-specific dependency subscales for NEI VFQ-25 scores in the visual search treatment arm. Trial Registration: Current Controlled Trials ISRCTN05956042.
AB - Background:: We conduct supplementary analyses of the NEI VFQ-25 data to evaluate where changes occurred within subscales of the NEI VFQ-25 leading to change in the composite scores between the three treatment arms, and evaluate the NEI VFQ-25 with and without the Neuro 10 supplement. Methods:: A prospective, multicentre, parallel, single-blind, three-arm RCT of fourteen UK acute stroke units was conducted. Stroke survivors with homonymous hemianopia were recruited. Interventions included: Fresnel prisms for minimum 2 h, 5 days/week over 6-weeks (Arm a), Visual search training for minimum 30 min, 5 days/week over 6-weeks (Arm b) and standard care-information only (Arm c). Primary and secondary outcomes (including NEI VFQ-25 data) were measured at baseline, 6, 12 and 26 weeks after randomisation. Results:: Eighty seven patients were recruited (69% male; mean age (SD) equal to 69 (12) years). At 26 weeks, outcomes for 24, 24 and 22 patients, respectively, were compared to baseline. NEI VFQ-25 (with and without Neuro 10) responses improved from baseline to 26 weeks with visual search training compared to Fresnel prisms and standard care. In subscale analysis, the most impacted across all treatment arms was ‘driving’ whilst the least impacted were ‘colour vision’ and ‘ocular pain’. Conclusions:: Composite scores differed systematically for the NEI VFQ-25 (Neuro 10) versus NEI VFQ-25 at all time points. For subscale scores, descriptive statistics suggest clinically relevant improvement in distance activities and vision-specific dependency subscales for NEI VFQ-25 scores in the visual search treatment arm. Trial Registration: Current Controlled Trials ISRCTN05956042.
KW - homonymous hemianopia
KW - pilot trial
KW - prism therapy
KW - randomised controlled trial
KW - standard care
KW - stroke
KW - visual search training
KW - Visual Function Questionnaire-25
KW - quality of life
KW - Single-Blind Method
KW - Prospective Studies
KW - Sickness Impact Profile
KW - Hemianopsia/physiopathology
KW - Humans
KW - Middle Aged
KW - Stroke/physiopathology
KW - Male
KW - Visual Acuity/physiology
KW - Visual Fields/physiology
KW - Quality of Life
KW - Female
KW - Surveys and Questionnaires
KW - Aged
KW - Outcome Assessment, Health Care
U2 - 10.1038/s41433-019-0441-z
DO - 10.1038/s41433-019-0441-z
M3 - Article
C2 - 30996338
VL - 33
SP - 1485
EP - 1493
JO - Eye
JF - Eye
SN - 0950-222X
ER -