Using ultrasound elastography to assess non-invasive, non-pharmacological interventions for musculoskeletal stiffness: a systematic review and meta-analysis

Tiev Miller, Umar M. Bello, Charlotte S.L. Tsang, Stanley J. Winser, Michael T.C. Ying, Marco Y.C. Pang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)
73 Downloads (Pure)

Abstract

Purpose
To evaluate the current evidence regarding the use of ultrasound elastography for assessing non-invasive, non-pharmacological interventions for eliciting changes in musculoskeletal stiffness.
Methods
A systematic search of MEDLINE, CINAHL, EMBASE, and Web of Science databases was performed in accordance with Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines. Information on measurement and intervention procedures was extracted. Bias was assessed using Cochrane Risk of Bias or Risk of Bias In Non-randomised Studies of Interventions (ROBINS-I) tools for studies with true or quasi-experimental designs, respectively. Analyses were conducted for adequately powered subgroups based on intervention type, measurement site, and population assessed.
Results
Twenty-one studies were included in the review. Overall risk of bias was low for true experimental studies and moderate for quasi-experimental studies. Subgroup analyses indicated a large overall effect for interventions involving manual physiotherapy and taping/splinting for reducing masseter muscle stiffness in patients with masticatory muscle disorders (g = 1.488, 95% CI = 0.320–2.655, p = 0.013). Analyses for other intervention types and patient groups were underpowered.
Conclusion
Ultrasound elastography demonstrates clinical applicability for assessing non-invasive, non-pharmacological interventions for musculoskeletal stiffness. However, the comparative efficacy of these interventions for modulating tissue stiffness remains inconclusive.
Original languageEnglish
Pages (from-to)3549-3563
Number of pages15
JournalDisability and Rehabilitation
Volume46
Issue number16
Early online date5 Sept 2023
DOIs
Publication statusPublished - 2024

Keywords

  • ultrasonography
  • elasticity imaging techniques
  • musculoskeletal system
  • conservative treatment
  • physical therapy modalities

ASJC Scopus subject areas

  • Rehabilitation

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