Using chirality to influence supramolecular gelation

Kate McAulay; Bart Dietrich; Hao Su; Michael T. Scott; Sarah Rogers; Youssra K. Al-Hilaly; Honggang Cui; Louise C.  Serpell; Annela M. Seddon; Emily R. Draper; Dave J. Adams

doi:10.1039/C9SC02239B

Using chirality to influence supramolecular gelation

Kate McAulay, Bart Dietrich, Hao Su, Michael T. Scott, Sarah Rogers, Youssra K. Al-Hilaly, Honggang Cui, Louise C. Serpell, Annela M. Seddon, Emily R. Draper, Dave J. Adams

Chemical Science

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

82 Downloads (Pure)

Abstract

Most low molecular weight gelators are chiral, with racemic mixtures often unable to form gels. Here, we show an example where all enantiomers, diastereomers and racemates of a single functionalized dipeptide can form gels. At high pH, different self-assembled aggregates are formed and these directly template the structures formed in the gel. Hence, solutions and gels with different properties can be accessed simply by varying the chirality. This opens up new design rules for the field.

Original language	English
Pages (from-to)	7801-7806
Number of pages	6
Journal	Chemical Science
Volume	10
Issue number	33
DOIs	https://doi.org/10.1039/C9SC02239B
Publication status	Published - 7 Sept 2019

Keywords

hydrogel
chiral
small angle scattering

ASJC Scopus subject areas

General Chemistry

Documents and Links

10.1039/C9SC02239B

McAulay, K. et al (2019) Using chirality to influence supramolecular gelation
This Open Access Article is licensed under a Creative Commons Attribution 3.0 Unported Licence. © The Royal Society of Chemistry 2019
Final published version, 1.31 MBLicence: CC BY

46 Citations
1 Article

Controlling the properties of the micellar and gel phase by varying the counterion in functionalised-dipeptide systems
McAulay, K., Agis Ucha, P., Wang, H., Fuentes-Caparrós, A. M., Thomson, L., Maklad, O., Khunti, N., Cowieson, N., Wallace, M., Cui, H., Poole, R. J., Seddon, A. & Adams, D. J., 5 Mar 2020, In: Chemical Communications. 56, 29, p. 4094-4097 4 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
28 Citations (Scopus)

88 Downloads (Pure)

Cite this

@article{791910e429474a1b96fca7320eb19d61,

title = "Using chirality to influence supramolecular gelation",

abstract = "Most low molecular weight gelators are chiral, with racemic mixtures often unable to form gels. Here, we show an example where all enantiomers, diastereomers and racemates of a single functionalized dipeptide can form gels. At high pH, different self-assembled aggregates are formed and these directly template the structures formed in the gel. Hence, solutions and gels with different properties can be accessed simply by varying the chirality. This opens up new design rules for the field.",

keywords = "hydrogel, chiral, small angle scattering",

author = "Kate McAulay and Bart Dietrich and Hao Su and Scott, {Michael T.} and Sarah Rogers and Al-Hilaly, {Youssra K.} and Honggang Cui and Serpell, {Louise C.} and Seddon, {Annela M.} and Draper, {Emily R.} and Adams, {Dave J.}",

note = "Acceptance from webpage OA article Applied Gold exception as journal is OA and would be immediate OA with acceptable CC licence. ET 16/1/20 ",

year = "2019",

month = sep,

day = "7",

doi = "10.1039/C9SC02239B",

language = "English",

volume = "10",

pages = "7801--7806",

journal = "Chemical Science",

issn = "2041-6539",

publisher = "RSC Publishing",

number = "33",

}

TY - JOUR

T1 - Using chirality to influence supramolecular gelation

AU - McAulay, Kate

AU - Dietrich, Bart

AU - Su, Hao

AU - Scott, Michael T.

AU - Rogers, Sarah

AU - Al-Hilaly, Youssra K.

AU - Cui, Honggang

AU - Serpell, Louise C.

AU - Seddon, Annela M.

AU - Draper, Emily R.

AU - Adams, Dave J.

N1 - Acceptance from webpage OA article Applied Gold exception as journal is OA and would be immediate OA with acceptable CC licence. ET 16/1/20

PY - 2019/9/7

Y1 - 2019/9/7

N2 - Most low molecular weight gelators are chiral, with racemic mixtures often unable to form gels. Here, we show an example where all enantiomers, diastereomers and racemates of a single functionalized dipeptide can form gels. At high pH, different self-assembled aggregates are formed and these directly template the structures formed in the gel. Hence, solutions and gels with different properties can be accessed simply by varying the chirality. This opens up new design rules for the field.

AB - Most low molecular weight gelators are chiral, with racemic mixtures often unable to form gels. Here, we show an example where all enantiomers, diastereomers and racemates of a single functionalized dipeptide can form gels. At high pH, different self-assembled aggregates are formed and these directly template the structures formed in the gel. Hence, solutions and gels with different properties can be accessed simply by varying the chirality. This opens up new design rules for the field.

KW - hydrogel

KW - chiral

KW - small angle scattering

U2 - 10.1039/C9SC02239B

DO - 10.1039/C9SC02239B

M3 - Article

C2 - 31588329

SN - 2041-6539

VL - 10

SP - 7801

EP - 7806

JO - Chemical Science

JF - Chemical Science

IS - 33

ER -

Using chirality to influence supramolecular gelation

Abstract

Keywords

ASJC Scopus subject areas

Documents and Links

Fingerprint

Research output

Controlling the properties of the micellar and gel phase by varying the counterion in functionalised-dipeptide systems

Cite this