Urethral bulking agents: a retrospective review of primary versus salvage procedure outcomes

Ciara M.E. Daly*, Jini Mathew, Judey Aloyscious, Suzanne Hagen, Veenu Tyagi, Karen L. Guerrero

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)
117 Downloads (Pure)


PURPOSE: Urethral bulking agents (UBA) have traditionally been offered as salvage procedures for recurrent stress urinary incontinence (SUI). We compare the success of UBA in patients that had undergone a previous procedure for SUI (Salvage-UBA) to the SUI surgery naïve (Primary-UBA). We hypothesised a positive effect in both Primary and Salvage-UBA with potentially poorer rates of response in the salvage group.

METHODS: Retrospective case series of patients having their first UBA (2010-2018). Primary outcome was to assess any difference in patient reported success between groups. Patient-reported improvement was assessed on a 4-point scale: 'cured, improved, no change, worse' and treatment 'success' defined as 'cured' or 'improved'. A multivariate analysis, adjusting for plausible differences between groups, was undertaken in IBM SPSS Statistics (2016).

RESULTS: 135 Primary-UBA and 38 Salvage-UBA were performed. Complete follow-up was obtained for 114 patients (66%): 86 Primary and 28 Salvage. Median follow-up time: 33 months. In 2012, 47% (8/17) of all UBA were Salvage-UBA, whilst in 2018, the majority were Primary-UBA (92%, 46/50). Success was not significantly different between Salvage-UBA 75% (21/28) versus Primary-UBA 67% (58/86) (Wald χ2 = 0.687, df = 1, p = 0.407). Top-up rates were similar: 14% (n = 4/28, Salvage-UBA) versus 15% (n = 13/86, Primary-UBA) (χ2 = 0.011, df = 1, p = 0.914).

CONCLUSION: The number of women opting for UBA has increased substantially. No significant differences were noted for success with Salvage-UBA compared to Primary-UBA.

Original languageEnglish
Pages (from-to)2107-2112
Number of pages6
JournalWorld journal of urology
Issue number6
Early online date20 Aug 2020
Publication statusPublished - Jun 2021


  • urethral
  • bulking
  • incontinence
  • primary
  • salvage

ASJC Scopus subject areas

  • Urology


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