Unusual serological response to hepatitis E virus in plasma donors consistent with re-infection

S.A. Baylis, Claire Crossan, V.M. Corman, J. Blumel, Linda Scobie, H.R. Dalton

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Hepatitis E virus (HEV)-positive plasma donations, identified by a plasma mini-pool screening approach, were analysed using serological methods for the presence of anti-HEV IgM and IgG. Avidity testing was performed on the IgG-reactive donations. Anti-HEV IgG with high avidity was observed in two donors together with high viral loads, but with the absence of anti-HEV IgM. These data are suggestive of re-infection in a small proportion of plasma donors, which has not previously been reported.

Original languageEnglish
Pages (from-to)406-409
Number of pages4
JournalVox Sanguinis
Volume109
Issue number4
Early online date29 May 2015
DOIs
Publication statusPublished - Nov 2015

Keywords

  • HEV testing
  • NAT testing
  • avidity test
  • reinfection risk

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