Unravelling the nature of postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: the role of elastase, complement C4a and interleukin-1 beta

J. Nijs, J. Van Oosterwijck, M. Meeus, L. Lambrecht, K. Metzger, M. Fremont, L. Paul

    Research output: Contribution to journalArticle

    Abstract

    Objectives. Too vigorous exercise or activity increase frequently triggers postexertional malaise in people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a primary characteristic evident in up to 95% of people with ME/CFS. The present study aimed at examining whether two different types of exercise results in changes in health status, circulating elastase activity, interleukin (IL)-1 beta and complement C4a levels.
    Design. Comparative experimental design.
    Setting. University.
    Subjects. Twenty-two women with ME/CFS and 22 healthy sedentary controls Interventions: participants were subjected to a submaximal exercise (day 8) and a self-paced, physiologically limited exercise (day 16). Each bout of exercise was preceded and followed by blood sampling, actigraphy and assessment of their health status.
    Results. Both submaximal exercise and self-paced, physiologically limited exercise resulted in postexertional malaise in people with ME/CFS. However, neither exercise bout altered elastase activity, IL-1 beta or complement C4a split product levels in people with ME/CFS or healthy sedentary control subjects (P gt; 0.05). Postexercise complement C4a level was identified as a clinically important biomarker for postexertional malaise in people with ME/CFS.
    Conclusions. Submaximal exercise as well as self-paced, physiologically limited exercise triggers postexertional malaise in people with ME/CFS, but neither types of exercise alter acute circulating levels of IL-1 beta, complement C4a split product or elastase activity. Further studying of immune alterations in relation to postexertional malaise in people with ME/CFS using multiple measurement points postexercise is required
    Original languageEnglish
    Pages (from-to)418-435
    Number of pages18
    JournalJournal of Internal Medicine
    Volume267
    Issue number4
    DOIs
    Publication statusPublished - Apr 2010

    Fingerprint

    Complement C4a
    Chronic Fatigue Syndrome
    Pancreatic Elastase
    Interleukin-1beta
    Exercise
    Health Status

    Keywords

    • allergy
    • women
    • blood care
    • chronic fatigue syndrome
    • exercise
    • fibromyalgia
    • graded-exercise
    • health
    • human
    • immune dysfunction
    • immunity
    • in-vivo
    • increased intervention level
    • measurement oxidative stress
    • pain
    • people performance
    • postexertional malaise

    Cite this

    @article{03903f0acda14a6d8064849a1b30ed81,
    title = "Unravelling the nature of postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: the role of elastase, complement C4a and interleukin-1 beta",
    abstract = "Objectives. Too vigorous exercise or activity increase frequently triggers postexertional malaise in people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a primary characteristic evident in up to 95{\%} of people with ME/CFS. The present study aimed at examining whether two different types of exercise results in changes in health status, circulating elastase activity, interleukin (IL)-1 beta and complement C4a levels.Design. Comparative experimental design.Setting. University.Subjects. Twenty-two women with ME/CFS and 22 healthy sedentary controls Interventions: participants were subjected to a submaximal exercise (day 8) and a self-paced, physiologically limited exercise (day 16). Each bout of exercise was preceded and followed by blood sampling, actigraphy and assessment of their health status.Results. Both submaximal exercise and self-paced, physiologically limited exercise resulted in postexertional malaise in people with ME/CFS. However, neither exercise bout altered elastase activity, IL-1 beta or complement C4a split product levels in people with ME/CFS or healthy sedentary control subjects (P gt; 0.05). Postexercise complement C4a level was identified as a clinically important biomarker for postexertional malaise in people with ME/CFS.Conclusions. Submaximal exercise as well as self-paced, physiologically limited exercise triggers postexertional malaise in people with ME/CFS, but neither types of exercise alter acute circulating levels of IL-1 beta, complement C4a split product or elastase activity. Further studying of immune alterations in relation to postexertional malaise in people with ME/CFS using multiple measurement points postexercise is required",
    keywords = "allergy , women, blood care, chronic fatigue syndrome, exercise, fibromyalgia, graded-exercise, health, human, immune dysfunction, immunity, in-vivo, increased intervention level, measurement oxidative stress, pain, people performance, postexertional malaise",
    author = "J. Nijs and Oosterwijck, {J. Van} and M. Meeus and L. Lambrecht and K. Metzger and M. Fremont and L. Paul",
    year = "2010",
    month = "4",
    doi = "10.1111/j.1365-2796.2009.02178.x",
    language = "English",
    volume = "267",
    pages = "418--435",
    journal = "Journal of Internal Medicine",
    issn = "0954-6820",
    number = "4",

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    Unravelling the nature of postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: the role of elastase, complement C4a and interleukin-1 beta. / Nijs, J.; Oosterwijck, J. Van; Meeus, M.; Lambrecht, L.; Metzger, K.; Fremont, M.; Paul, L.

    In: Journal of Internal Medicine, Vol. 267, No. 4, 04.2010, p. 418-435.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Unravelling the nature of postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: the role of elastase, complement C4a and interleukin-1 beta

    AU - Nijs, J.

    AU - Oosterwijck, J. Van

    AU - Meeus, M.

    AU - Lambrecht, L.

    AU - Metzger, K.

    AU - Fremont, M.

    AU - Paul, L.

    PY - 2010/4

    Y1 - 2010/4

    N2 - Objectives. Too vigorous exercise or activity increase frequently triggers postexertional malaise in people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a primary characteristic evident in up to 95% of people with ME/CFS. The present study aimed at examining whether two different types of exercise results in changes in health status, circulating elastase activity, interleukin (IL)-1 beta and complement C4a levels.Design. Comparative experimental design.Setting. University.Subjects. Twenty-two women with ME/CFS and 22 healthy sedentary controls Interventions: participants were subjected to a submaximal exercise (day 8) and a self-paced, physiologically limited exercise (day 16). Each bout of exercise was preceded and followed by blood sampling, actigraphy and assessment of their health status.Results. Both submaximal exercise and self-paced, physiologically limited exercise resulted in postexertional malaise in people with ME/CFS. However, neither exercise bout altered elastase activity, IL-1 beta or complement C4a split product levels in people with ME/CFS or healthy sedentary control subjects (P gt; 0.05). Postexercise complement C4a level was identified as a clinically important biomarker for postexertional malaise in people with ME/CFS.Conclusions. Submaximal exercise as well as self-paced, physiologically limited exercise triggers postexertional malaise in people with ME/CFS, but neither types of exercise alter acute circulating levels of IL-1 beta, complement C4a split product or elastase activity. Further studying of immune alterations in relation to postexertional malaise in people with ME/CFS using multiple measurement points postexercise is required

    AB - Objectives. Too vigorous exercise or activity increase frequently triggers postexertional malaise in people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a primary characteristic evident in up to 95% of people with ME/CFS. The present study aimed at examining whether two different types of exercise results in changes in health status, circulating elastase activity, interleukin (IL)-1 beta and complement C4a levels.Design. Comparative experimental design.Setting. University.Subjects. Twenty-two women with ME/CFS and 22 healthy sedentary controls Interventions: participants were subjected to a submaximal exercise (day 8) and a self-paced, physiologically limited exercise (day 16). Each bout of exercise was preceded and followed by blood sampling, actigraphy and assessment of their health status.Results. Both submaximal exercise and self-paced, physiologically limited exercise resulted in postexertional malaise in people with ME/CFS. However, neither exercise bout altered elastase activity, IL-1 beta or complement C4a split product levels in people with ME/CFS or healthy sedentary control subjects (P gt; 0.05). Postexercise complement C4a level was identified as a clinically important biomarker for postexertional malaise in people with ME/CFS.Conclusions. Submaximal exercise as well as self-paced, physiologically limited exercise triggers postexertional malaise in people with ME/CFS, but neither types of exercise alter acute circulating levels of IL-1 beta, complement C4a split product or elastase activity. Further studying of immune alterations in relation to postexertional malaise in people with ME/CFS using multiple measurement points postexercise is required

    KW - allergy

    KW - women

    KW - blood care

    KW - chronic fatigue syndrome

    KW - exercise

    KW - fibromyalgia

    KW - graded-exercise

    KW - health

    KW - human

    KW - immune dysfunction

    KW - immunity

    KW - in-vivo

    KW - increased intervention level

    KW - measurement oxidative stress

    KW - pain

    KW - people performance

    KW - postexertional malaise

    U2 - 10.1111/j.1365-2796.2009.02178.x

    DO - 10.1111/j.1365-2796.2009.02178.x

    M3 - Article

    VL - 267

    SP - 418

    EP - 435

    JO - Journal of Internal Medicine

    JF - Journal of Internal Medicine

    SN - 0954-6820

    IS - 4

    ER -