Whilst deep brain stimulation of the subthalamic nucleus (DBS-STN) improves the motor symptoms of Parkinson's disease (PD), its effect on daily activity is unknown. We aimed to quantify changes in ambulatory activity following DBS-STN in advanced PD using novel accelerometry based measures that describe changes to the volume and pattern of walking. Seventeen participants with advanced PD were measured over a 7-day period using an activPAL activity monitor. Data were collected 6weeks before and 6months after surgery and included measures that describe the volume and pattern of ambulatory activity (number of steps per day, accumulation, diversity and variability of walking time), alongside standard measures for disease severity, freezing of gait, gait speed, and extended activities of daily living. Activity outcomes were compared pre- and 6months post-surgery using linear mixed models and correlated with standard outcomes.
- deep brain stimulation
- ambulatory activity
- Parkinson's disease
- walking patterns
Rochester, L., Chastin, S. F. M., Lord, S., Baker, K., & Burn, D. J. (2012). Understanding the impact of deep brain stimulation on ambulatory activity in advanced Parkinson’s disease. European Journal of Neurology, 259(6), 1081-1086. https://doi.org/10.1007/s00415-011-6301-9