Ultrastructure of the hyperhidrotic eccrine sweat gland

Douglas L. Bovell, M. T. Clunes, H. Y. Elder, J. Milsom, D. McEwan Jenkinson

Research output: Contribution to journalArticle

Abstract

Hyperhidrosis is the secretion of inappropriately large amounts of sweat by eccrine glands; it can be very debilitating. Little is known of the causes of primary hyperhidrosis. Objectives were to determine whether the glands exhibit any structural abnormality in primary hyperhidrosis. Skin biopsies were obtained from the axilla (n = 6) or neck (n = 2) of individuals aged 26–62 years with primary hyperhidrosis and from five age- and sex-matched normal individuals, with informed consent and ethical committee approval. Samples were prepared by standard methods for light and electron microscopic examination. All characteristics observed in the hyperhidrotic specimens were consistent with the changes seen in normal glands following strong activation: degranulation of the granular (dark) cells, dilatation of the basolateral infoldings and the canaliculi of the non-granular (clear) cells, contraction of the myoepithelial cells and thickening of the basal lamina, and presence of cellular debris including lipid droplets in the gland lumen. Pathological changes were not observed. The present finding of the absence of structural defects in the glands indicates that future studies should concentrate on the investigation of neurohumoral or secretory cell metabolic abnormalities.

Original languageEnglish
Pages (from-to)298-301
Number of pages4
JournalBritish Journal of Dermatology
Volume145
Issue number2
DOIs
Publication statusPublished - 1 Dec 2001

Keywords

  • electron microscopy
  • hyperhidrosis
  • eccrine sweat glands

Fingerprint Dive into the research topics of 'Ultrastructure of the hyperhidrotic eccrine sweat gland'. Together they form a unique fingerprint.

  • Cite this

    Bovell, D. L., Clunes, M. T., Elder, H. Y., Milsom, J., & McEwan Jenkinson, D. (2001). Ultrastructure of the hyperhidrotic eccrine sweat gland. British Journal of Dermatology, 145(2), 298-301. https://doi.org/10.1046/j.1365-2133.2001.04351.x