Tuning the antimicrobial activity of low molecular weight hydrogels using dopamine autoxidation

Emily R. Cross, Sophie M. Coulter, Ana M. Fuentes-Caparrós, Kate McAulay, Ralf Schweins, Garry Laverty*, Dave J. Adams*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Abstract

We present a method to trigger the formation of dipeptide-based hydrogels by the simple addition of dopamine.We present a method to trigger the formation of dipeptide-based hydrogels by the simple addition of dopamine. Dopamine undergoes oxidation in air, reducing the pH to induce gelation. The production of polydopamine and release of reactive oxygen species such as hydrogen peroxide confers antimicrobial activity. Gel stiffness can be controlled by modulating the initial starting pH of the gelator solution. We can use this method to tune the antimicrobial activity of the gels, with gels that are less stiff demonstrating increased bactericidal efficacy against Gram-positive bacteria.
Original languageEnglish
Pages (from-to)8726-8734
Number of pages9
JournalChemical Communications
Issue number58
DOIs
Publication statusPublished - 10 Jun 2020

Keywords

  • gel
  • dipeptide
  • bacteria
  • hydrogel
  • dopamine
  • SANS
  • neutrons

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