Treatment of hepatitis C virus infection among people who are actively injecting drugs: a systematic review and meta-analysis

Esther J. Aspinall, Stephen Corson, Joseph S. Doyle, Jason Grebely, Sharon Hutchinson, Gregory J. Dore, David Goldberg, Margaret E. Hellard

Research output: Contribution to journalArticle

Abstract

Although guidelines recommend that people who inject drugs (PWID) should not be excluded from hepatitis C (HCV) treatment, some services remain reluctant to treat PWID. The aim of this review was to investigate sustained virologic response (SVR), adherence, discontinuation, and HCV reinfection among PWID. A search of Medline, Embase, and Cochrane databases (between 2002 and January 2012) was conducted for primary articles/conference abstracts examining HCV treatment outcomes in PWID. Meta-analysis was used to obtain pooled estimates of SVR, adherence, discontinuation, and HCV reinfection.
Original languageEnglish
Pages (from-to)S80-89
Number of pages10
JournalClinical Infectious Diseases
Volume53
Issue numberSuppl 2
DOIs
Publication statusPublished - Aug 2013

Keywords

  • hepatitis C virus
  • drug users
  • sustained virologic response
  • virus infection

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