Toxicity assessment of four pharmaceuticals in aquatic environment before and after ferrate(VI) treatment

Srinath Patibandla, Jia-Qian Jiang, Xinhua Shu

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Abstract

Micro-pollutants in aquatic environment are an emerging challenge to the human health and ecosystems. This study was to investigate the acute toxicity before and after ferrate(VI) treatment for four pharmaceuticals (simvastatin, ivermectin, fluoxetine and oxytetracycline) at concentrations of 10 and 100¿µg/L, respectively. Zebrafish animal model and Vibrio fischeri luminescent test were employed to achieve the study targets. It is the first effort using the stated methods to assess toxicity of the selected pharmaceuticals before and after ferrate(VI) treatment when biochemical responses of catalase (CAT), tumour necrosis factor alpha (TNF-a), interleukin 1 beta (IL-1ß) and B-cell lymphoma 2 (Bcl-2) were assessed in the zebrafish model. The results firstly revealed a significant change in the gene expression of CAT (p¿<¿0.001), TNF-a SOD 1 (p¿<¿0.01), and Bcl-2 (p¿<¿0.05) for simvastatin at low concentrations, which exhibited high toxicity in comparison with other pharmaceuticals. Ferrate(VI) treatment significantly reduced the toxicity of simvastatin by partially removing it during the treatment process and ferrate(VI) itself did not produce additional toxicity in the effluent.
Original languageEnglish
Pages (from-to)3787-3797
Number of pages11
JournalJournal of Environmental Chemical Engineering
Volume6
Issue number4
Early online date23 May 2018
DOIs
Publication statusPublished - Aug 2018

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Drug products
aquatic environment
Toxicity
drug
Simvastatin
toxicity
Pharmaceutical Preparations
tumor
Catalase
Tumor Necrosis Factor-alpha
ivermectin
Ivermectin
Oxytetracycline
oxytetracycline
Fluoxetine
Interleukin-1beta
Gene expression
Ecosystems
gene expression
Effluents

Keywords

  • toxicity assessment
  • pharmaceutical industry
  • aquatic environment

Cite this

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title = "Toxicity assessment of four pharmaceuticals in aquatic environment before and after ferrate(VI) treatment",
abstract = "Micro-pollutants in aquatic environment are an emerging challenge to the human health and ecosystems. This study was to investigate the acute toxicity before and after ferrate(VI) treatment for four pharmaceuticals (simvastatin, ivermectin, fluoxetine and oxytetracycline) at concentrations of 10 and 100¿µg/L, respectively. Zebrafish animal model and Vibrio fischeri luminescent test were employed to achieve the study targets. It is the first effort using the stated methods to assess toxicity of the selected pharmaceuticals before and after ferrate(VI) treatment when biochemical responses of catalase (CAT), tumour necrosis factor alpha (TNF-a), interleukin 1 beta (IL-1{\ss}) and B-cell lymphoma 2 (Bcl-2) were assessed in the zebrafish model. The results firstly revealed a significant change in the gene expression of CAT (p¿<¿0.001), TNF-a SOD 1 (p¿<¿0.01), and Bcl-2 (p¿<¿0.05) for simvastatin at low concentrations, which exhibited high toxicity in comparison with other pharmaceuticals. Ferrate(VI) treatment significantly reduced the toxicity of simvastatin by partially removing it during the treatment process and ferrate(VI) itself did not produce additional toxicity in the effluent.",
keywords = "toxicity assessment , pharmaceutical industry , aquatic environment",
author = "Srinath Patibandla and Jia-Qian Jiang and Xinhua Shu",
note = "AAM: 12m embargo",
year = "2018",
month = "8",
doi = "10.1016/j.jece.2018.05.024",
language = "English",
volume = "6",
pages = "3787--3797",
journal = "Journal of Environmental Chemical Engineering",
issn = "2213-3437",
publisher = "Elsevier B.V.",
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TY - JOUR

T1 - Toxicity assessment of four pharmaceuticals in aquatic environment before and after ferrate(VI) treatment

AU - Patibandla, Srinath

AU - Jiang, Jia-Qian

AU - Shu, Xinhua

N1 - AAM: 12m embargo

PY - 2018/8

Y1 - 2018/8

N2 - Micro-pollutants in aquatic environment are an emerging challenge to the human health and ecosystems. This study was to investigate the acute toxicity before and after ferrate(VI) treatment for four pharmaceuticals (simvastatin, ivermectin, fluoxetine and oxytetracycline) at concentrations of 10 and 100¿µg/L, respectively. Zebrafish animal model and Vibrio fischeri luminescent test were employed to achieve the study targets. It is the first effort using the stated methods to assess toxicity of the selected pharmaceuticals before and after ferrate(VI) treatment when biochemical responses of catalase (CAT), tumour necrosis factor alpha (TNF-a), interleukin 1 beta (IL-1ß) and B-cell lymphoma 2 (Bcl-2) were assessed in the zebrafish model. The results firstly revealed a significant change in the gene expression of CAT (p¿<¿0.001), TNF-a SOD 1 (p¿<¿0.01), and Bcl-2 (p¿<¿0.05) for simvastatin at low concentrations, which exhibited high toxicity in comparison with other pharmaceuticals. Ferrate(VI) treatment significantly reduced the toxicity of simvastatin by partially removing it during the treatment process and ferrate(VI) itself did not produce additional toxicity in the effluent.

AB - Micro-pollutants in aquatic environment are an emerging challenge to the human health and ecosystems. This study was to investigate the acute toxicity before and after ferrate(VI) treatment for four pharmaceuticals (simvastatin, ivermectin, fluoxetine and oxytetracycline) at concentrations of 10 and 100¿µg/L, respectively. Zebrafish animal model and Vibrio fischeri luminescent test were employed to achieve the study targets. It is the first effort using the stated methods to assess toxicity of the selected pharmaceuticals before and after ferrate(VI) treatment when biochemical responses of catalase (CAT), tumour necrosis factor alpha (TNF-a), interleukin 1 beta (IL-1ß) and B-cell lymphoma 2 (Bcl-2) were assessed in the zebrafish model. The results firstly revealed a significant change in the gene expression of CAT (p¿<¿0.001), TNF-a SOD 1 (p¿<¿0.01), and Bcl-2 (p¿<¿0.05) for simvastatin at low concentrations, which exhibited high toxicity in comparison with other pharmaceuticals. Ferrate(VI) treatment significantly reduced the toxicity of simvastatin by partially removing it during the treatment process and ferrate(VI) itself did not produce additional toxicity in the effluent.

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