Therapeutic potential of co-enzyme Q10 in retinal diseases

Xun Zhang, Ali Mohammad Tohari, Fabio Marcheggiani, Xinzhi Zhou, James Reilly, Luca Tiano, Xinhua Shu

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Abstract

Coenzyme Q10 (CoQ10) plays a critical role in mitochondrial oxidative phosphorylation by serving as an electron carrier in the respiratory electron transport chain. CoQ10 also functions as a lipid-soluble antioxidant by protecting lipids, proteins and DNA damaged by oxidative stress. CoQ10 deficiency has been associated with a number of human diseases including mitochondrial diseases, neurodegenerative disorders, cardiovascular diseases, diabetes, cancer, and with the ageing process. In many of these conditions CoQ10 supplementation therapy has been effective in slowing or reversing pathological changes. Oxidative stress is a major contributory factor in the process of retinal degeneration. In this brief review, we summarize the functions of CoQ10 and highlight its use in the treatment of age-related macular degeneration and glaucoma. In light of these data we propose that CoQ10 could have therapeutic potential for other retinal diseases.
Original languageEnglish
Pages (from-to)4329-4339
Number of pages11
JournalCurrent Medicinal Chemistry
Volume24
Issue number39
Early online date1 Aug 2017
DOIs
Publication statusPublished - 2017

Keywords

  • co-enzyme Q10, oxidative stress, retina, age related macular degeneration, glaucoma, retinitis pigmentosa, diabetic retinopathy, protection

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