Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 4329-4339 |
| Number of pages | 11 |
| Journal | Current Medicinal Chemistry |
| Volume | 24 |
| Issue number | 39 |
| Early online date | 1 Aug 2017 |
| DOIs | |
| Publication status | Published - 2017 |
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Keywords
- co-enzyme Q10, oxidative stress, retina, age related macular degeneration, glaucoma, retinitis pigmentosa, diabetic retinopathy, protection
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Therapeutic potential of co-enzyme Q10 in retinal diseases. / Zhang, Xun; Tohari, Ali Mohammad; Marcheggiani, Fabio; Zhou, Xinzhi; Reilly, James; Tiano, Luca; Shu, Xinhua.
In: Current Medicinal Chemistry, Vol. 24, No. 39, 2017, p. 4329-4339.Research output: Contribution to journal › Article
TY - JOUR
T1 - Therapeutic potential of co-enzyme Q10 in retinal diseases
AU - Zhang, Xun
AU - Tohari, Ali Mohammad
AU - Marcheggiani, Fabio
AU - Zhou, Xinzhi
AU - Reilly, James
AU - Tiano, Luca
AU - Shu, Xinhua
N1 - Acceptance email in SAN Epub date from PubMed AAM: 12m embargo
PY - 2017
Y1 - 2017
N2 - Coenzyme Q10 (CoQ10) plays a critical role in mitochondrial oxidative phosphorylation by serving as an electron carrier in the respiratory electron transport chain. CoQ10 also functions as a lipid-soluble antioxidant by protecting lipids, proteins and DNA damaged by oxidative stress. CoQ10 deficiency has been associated with a number of human diseases including mitochondrial diseases, neurodegenerative disorders, cardiovascular diseases, diabetes, cancer, and with the ageing process. In many of these conditions CoQ10 supplementation therapy has been effective in slowing or reversing pathological changes. Oxidative stress is a major contributory factor in the process of retinal degeneration. In this brief review, we summarize the functions of CoQ10 and highlight its use in the treatment of age-related macular degeneration and glaucoma. In light of these data we propose that CoQ10 could have therapeutic potential for other retinal diseases.
AB - Coenzyme Q10 (CoQ10) plays a critical role in mitochondrial oxidative phosphorylation by serving as an electron carrier in the respiratory electron transport chain. CoQ10 also functions as a lipid-soluble antioxidant by protecting lipids, proteins and DNA damaged by oxidative stress. CoQ10 deficiency has been associated with a number of human diseases including mitochondrial diseases, neurodegenerative disorders, cardiovascular diseases, diabetes, cancer, and with the ageing process. In many of these conditions CoQ10 supplementation therapy has been effective in slowing or reversing pathological changes. Oxidative stress is a major contributory factor in the process of retinal degeneration. In this brief review, we summarize the functions of CoQ10 and highlight its use in the treatment of age-related macular degeneration and glaucoma. In light of these data we propose that CoQ10 could have therapeutic potential for other retinal diseases.
KW - co-enzyme Q10, oxidative stress, retina, age related macular degeneration, glaucoma, retinitis pigmentosa, diabetic retinopathy, protection
U2 - 10.2174/0929867324666170801100516
DO - 10.2174/0929867324666170801100516
M3 - Article
VL - 24
SP - 4329
EP - 4339
JO - Current Medicinal Chemistry
JF - Current Medicinal Chemistry
SN - 0929-8673
IS - 39
ER -