Abstract
Coenzyme Q10 (CoQ10) plays a critical role in mitochondrial oxidative phosphorylation by serving as an electron carrier in the respiratory electron transport chain. CoQ10 also functions as a lipid-soluble antioxidant by protecting lipids, proteins and DNA damaged by oxidative stress. CoQ10 deficiency has been associated with a number of human diseases including mitochondrial diseases, neurodegenerative disorders, cardiovascular diseases, diabetes, cancer, and with the ageing process. In many of these conditions CoQ10 supplementation therapy has been effective in slowing or reversing pathological changes. Oxidative stress is a major contributory factor in the process of retinal degeneration. In this brief review, we summarize the functions of CoQ10 and highlight its use in the treatment of age-related macular degeneration and glaucoma. In light of these data we propose that CoQ10 could have therapeutic potential for other retinal diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 4329-4339 |
| Number of pages | 11 |
| Journal | Current Medicinal Chemistry |
| Volume | 24 |
| Issue number | 39 |
| Early online date | 1 Aug 2017 |
| DOIs | |
| Publication status | Published - 21 Dec 2017 |
Keywords
- Glaucoma
- Diabetic retinopathy
- Oxidative stress
- Retinitis pigmentosa
- Co-enzyme Q10
- Age related macular degeneration
- Retina
- Protection
ASJC Scopus subject areas
- Drug Discovery
- Molecular Medicine
- Biochemistry
- Pharmacology
- Organic Chemistry
Documents and Links
- Zhang, X. et al (2017) Therapeutic potential of co-enzyme Q10 in retinal diseases
This is an author final version of the article originally published in: Current Medicinal Chemistry (2017). The publisher version of this article is available via the DOI link below. © 2017 Bentham Science Publishers.