The serotonin transporter, gender, and 17ß oestradiol in the development of pulmonary arterial hypertension

Kevin White, Yvonne Dempsie, Margaret Nilsen, Audrey F. Wright, Lynn Loughlin, Margaret R. MacLean

Research output: Contribution to journalArticlepeer-review

Abstract

Idiopathic and familial forms of pulmonary arterial hypertension (PAH) predominantly affect females through an unknown mechanism. Activity of the serotonin transporter (SERT) may modulate the development of PAH, and mice overexpressing SERT (SERT+ mice) develop PAH and severe hypoxia-induced PAH. In the central nervous system, oestrogens influence activity of the serotonin system. Therefore, we examined the influence of gender on the development of PAH in SERT+ mice and how this is modulated by female hormones.
Original languageEnglish
Pages (from-to)373-382
Number of pages10
JournalCardiovascular Research
Volume90
Issue number2
DOIs
Publication statusPublished - May 2011

Keywords

  • serotonin transporter
  • pulmonary arterial hypertension
  • PAH
  • oestrogens

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