The serotonin transporter, gender, and 17ß oestradiol in the development of pulmonary arterial hypertension

Kevin White; Yvonne Dempsie; Margaret  Nilsen; Audrey F. Wright; Lynn Loughlin; Margaret R. MacLean

doi:10.1093/cvr/cvq408

The serotonin transporter, gender, and 17ß oestradiol in the development of pulmonary arterial hypertension

Kevin White, Yvonne Dempsie, Margaret Nilsen, Audrey F. Wright, Lynn Loughlin, Margaret R. MacLean

Biological and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

99 Citations (Scopus)

Abstract

Idiopathic and familial forms of pulmonary arterial hypertension (PAH) predominantly affect females through an unknown mechanism. Activity of the serotonin transporter (SERT) may modulate the development of PAH, and mice overexpressing SERT (SERT+ mice) develop PAH and severe hypoxia-induced PAH. In the central nervous system, oestrogens influence activity of the serotonin system. Therefore, we examined the influence of gender on the development of PAH in SERT+ mice and how this is modulated by female hormones.

Original language	English
Pages (from-to)	373-382
Number of pages	10
Journal	Cardiovascular Research
Volume	90
Issue number	2
DOIs	https://doi.org/10.1093/cvr/cvq408
Publication status	Published - May 2011

Keywords

serotonin transporter
pulmonary arterial hypertension
PAH
oestrogens

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10.1093/cvr/cvq408

Cite this

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AB - Idiopathic and familial forms of pulmonary arterial hypertension (PAH) predominantly affect females through an unknown mechanism. Activity of the serotonin transporter (SERT) may modulate the development of PAH, and mice overexpressing SERT (SERT+ mice) develop PAH and severe hypoxia-induced PAH. In the central nervous system, oestrogens influence activity of the serotonin system. Therefore, we examined the influence of gender on the development of PAH in SERT+ mice and how this is modulated by female hormones.

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KW - oestrogens

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The serotonin transporter, gender, and 17ß oestradiol in the development of pulmonary arterial hypertension

Abstract

Keywords

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