The selective metabotropic glutamate receptor 7 allosteric agonist AMN082 inhibits inflammatory pain- and incision-induced hypersensitivity in rat

Sharron Dolan, Mark D. Gunn, Laura Biddlestone, Andrea M. Nolan

Research output: Contribution to journalArticle

Abstract

This study characterized the contribution of metabotropic glutamate receptor 7 (mGlu7 receptor) activation to the development of inflammatory hyperalgesia and allodynia, using a novel, systemically active mGlu7 receptor allosteric agonist, N, N'-dibenzhydrylethane-1,2-diamine dihydrochloride (AMN082). The effects of AMN082 (0.1, 1 or 5 mg/kg, intraperitoneally; 5 or 50 nmol, intrathecally) or diclofenac (5 mg/kg, intraperitoneally) administered 30 min preprocedure or 3 h postprocedure on hindpaw withdrawal latency (in seconds) to thermal stimulation, and response threshold (in grams) to mechanical stimulation, were measured in adult rats (n = 6-8 per group) before and up to 24 h after intradermal injection of carrageenan into the hindpaw or hindpaw incision.

Original languageEnglish
Pages (from-to)596-604
Number of pages9
JournalBehavioural Pharmacology
Volume20
Issue number7
DOIs
Publication statusPublished - 1 Oct 2009

Keywords

  • pain
  • agonist
  • pharmacology

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