The secretory clear cell of the eccrine sweat gland as the probable source of excess sweat production in hyperhidrosis

Douglas Bovell, Alison MacDonald, Barbara A. Meyer, Alistair Corbett, William MacLaren, Susan L. Holmes, Mark Harker

Research output: Contribution to journalArticle

Abstract

Primary hyperhidrosis is characterized by excessive sweating in palmar, plantar and axillary body regions. Gland hypertrophy and the existence of a third type of sweat gland, the apoeccrine gland, with high fluid transporting capabilities have been suggested as possible causes. This study investigated whether sweat glands were hypertrophied in axillary hyperhidrotic patients and if mechanisms associated with fluid transport were found in all types of axillary sweat glands. The occurrence of apoeccrine sweat glands was also investigated. Axillary skin biopsies from control and hyperhidrosis patients were examined using immunohistochemistry, image analysis and immunofluorescence microscopy.
Original languageEnglish
Pages (from-to)1017–1020
Number of pages4
JournalExperimental Dermatology
Volume20
Issue number12
DOIs
Publication statusPublished - Dec 2011

Keywords

  • eccrine sweat gland
  • hyperhidrosis
  • immunohistochemistry

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    Bovell, D., MacDonald, A., Meyer, B. A., Corbett, A., MacLaren, W., Holmes, S. L., & Harker, M. (2011). The secretory clear cell of the eccrine sweat gland as the probable source of excess sweat production in hyperhidrosis. Experimental Dermatology, 20(12), 1017–1020. https://doi.org/10.1111/j.1600-0625.2011.01361.x