The secretory clear cell of the eccrine sweat gland as the probable source of excess sweat production in hyperhidrosis

Douglas Bovell; Alison MacDonald; Barbara A. Meyer; Alistair Corbett; William MacLaren; Susan L. Holmes; Mark Harker

doi:10.1111/j.1600-0625.2011.01361.x

The secretory clear cell of the eccrine sweat gland as the probable source of excess sweat production in hyperhidrosis

Douglas Bovell, Alison MacDonald, Barbara A. Meyer, Alistair Corbett, William MacLaren, Susan L. Holmes, Mark Harker

SHLS School Office

Research output: Contribution to journal › Article › peer-review

Abstract

Primary hyperhidrosis is characterized by excessive sweating in palmar, plantar and axillary body regions. Gland hypertrophy and the existence of a third type of sweat gland, the apoeccrine gland, with high fluid transporting capabilities have been suggested as possible causes. This study investigated whether sweat glands were hypertrophied in axillary hyperhidrotic patients and if mechanisms associated with fluid transport were found in all types of axillary sweat glands. The occurrence of apoeccrine sweat glands was also investigated. Axillary skin biopsies from control and hyperhidrosis patients were examined using immunohistochemistry, image analysis and immunofluorescence microscopy.

Original language	English
Pages (from-to)	1017–1020
Number of pages	4
Journal	Experimental Dermatology
Volume	20
Issue number	12
DOIs	https://doi.org/10.1111/j.1600-0625.2011.01361.x
Publication status	Published - Dec 2011

Keywords

eccrine sweat gland
hyperhidrosis
immunohistochemistry

Documents and Links

10.1111/j.1600-0625.2011.01361.x

Publication in Scopus

Fingerprint Dive into the research topics of 'The secretory clear cell of the eccrine sweat gland as the probable source of excess sweat production in hyperhidrosis'. Together they form a unique fingerprint.

Cite this

@article{2d4cf00150aa48f8a1411526f92b701b,

title = "The secretory clear cell of the eccrine sweat gland as the probable source of excess sweat production in hyperhidrosis",

abstract = "Primary hyperhidrosis is characterized by excessive sweating in palmar, plantar and axillary body regions. Gland hypertrophy and the existence of a third type of sweat gland, the apoeccrine gland, with high fluid transporting capabilities have been suggested as possible causes. This study investigated whether sweat glands were hypertrophied in axillary hyperhidrotic patients and if mechanisms associated with fluid transport were found in all types of axillary sweat glands. The occurrence of apoeccrine sweat glands was also investigated. Axillary skin biopsies from control and hyperhidrosis patients were examined using immunohistochemistry, image analysis and immunofluorescence microscopy. ",

keywords = "eccrine sweat gland, hyperhidrosis, immunohistochemistry",

author = "Douglas Bovell and Alison MacDonald and Meyer, {Barbara A.} and Alistair Corbett and William MacLaren and Holmes, {Susan L.} and Mark Harker",

year = "2011",

month = dec,

doi = "10.1111/j.1600-0625.2011.01361.x",

language = "English",

volume = "20",

pages = "1017–1020",

journal = "Experimental Dermatology",

issn = "0906-6705",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "12",

}

The secretory clear cell of the eccrine sweat gland as the probable source of excess sweat production in hyperhidrosis. / Bovell, Douglas; MacDonald, Alison; Meyer, Barbara A.; Corbett, Alistair; MacLaren, William; Holmes, Susan L.; Harker, Mark.

In: Experimental Dermatology, Vol. 20, No. 12, 12.2011, p. 1017–1020.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The secretory clear cell of the eccrine sweat gland as the probable source of excess sweat production in hyperhidrosis

AU - Bovell, Douglas

AU - MacDonald, Alison

AU - Meyer, Barbara A.

AU - Corbett, Alistair

AU - MacLaren, William

AU - Holmes, Susan L.

AU - Harker, Mark

PY - 2011/12

Y1 - 2011/12

N2 - Primary hyperhidrosis is characterized by excessive sweating in palmar, plantar and axillary body regions. Gland hypertrophy and the existence of a third type of sweat gland, the apoeccrine gland, with high fluid transporting capabilities have been suggested as possible causes. This study investigated whether sweat glands were hypertrophied in axillary hyperhidrotic patients and if mechanisms associated with fluid transport were found in all types of axillary sweat glands. The occurrence of apoeccrine sweat glands was also investigated. Axillary skin biopsies from control and hyperhidrosis patients were examined using immunohistochemistry, image analysis and immunofluorescence microscopy.

AB - Primary hyperhidrosis is characterized by excessive sweating in palmar, plantar and axillary body regions. Gland hypertrophy and the existence of a third type of sweat gland, the apoeccrine gland, with high fluid transporting capabilities have been suggested as possible causes. This study investigated whether sweat glands were hypertrophied in axillary hyperhidrotic patients and if mechanisms associated with fluid transport were found in all types of axillary sweat glands. The occurrence of apoeccrine sweat glands was also investigated. Axillary skin biopsies from control and hyperhidrosis patients were examined using immunohistochemistry, image analysis and immunofluorescence microscopy.

KW - eccrine sweat gland

KW - hyperhidrosis

KW - immunohistochemistry

UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-81455141244&partnerID=8YFLogxK

U2 - 10.1111/j.1600-0625.2011.01361.x

DO - 10.1111/j.1600-0625.2011.01361.x

M3 - Article

AN - SCOPUS:81455141244

VL - 20

SP - 1017

EP - 1020

JO - Experimental Dermatology

JF - Experimental Dermatology

SN - 0906-6705

IS - 12

ER -