The secretory clear cell of the eccrine sweat gland as the probable source of excess sweat production in hyperhidrosis

Douglas Bovell, Alison MacDonald, Barbara A. Meyer, Alistair Corbett, William MacLaren, Susan L. Holmes, Mark Harker

Research output: Contribution to journalArticle

Abstract

Primary hyperhidrosis is characterized by excessive sweating in palmar, plantar and axillary body regions. Gland hypertrophy and the existence of a third type of sweat gland, the apoeccrine gland, with high fluid transporting capabilities have been suggested as possible causes. This study investigated whether sweat glands were hypertrophied in axillary hyperhidrotic patients and if mechanisms associated with fluid transport were found in all types of axillary sweat glands. The occurrence of apoeccrine sweat glands was also investigated. Axillary skin biopsies from control and hyperhidrosis patients were examined using immunohistochemistry, image analysis and immunofluorescence microscopy.
Original languageEnglish
Pages (from-to)1017–1020
Number of pages4
JournalExperimental Dermatology
Volume20
Issue number12
DOIs
Publication statusPublished - Dec 2011

Fingerprint

Eccrine Glands
Hyperhidrosis
Sweat Glands
Sweat
Fluids
Biopsy
Image analysis
Skin
Microscopic examination
Body Regions
Sweating
Fluorescence Microscopy
Hypertrophy
Immunohistochemistry

Keywords

  • eccrine sweat gland
  • hyperhidrosis
  • immunohistochemistry

Cite this

Bovell, D., MacDonald, A., Meyer, B. A., Corbett, A., MacLaren, W., Holmes, S. L., & Harker, M. (2011). The secretory clear cell of the eccrine sweat gland as the probable source of excess sweat production in hyperhidrosis. Experimental Dermatology, 20(12), 1017–1020. https://doi.org/10.1111/j.1600-0625.2011.01361.x
Bovell, Douglas ; MacDonald, Alison ; Meyer, Barbara A. ; Corbett, Alistair ; MacLaren, William ; Holmes, Susan L. ; Harker, Mark. / The secretory clear cell of the eccrine sweat gland as the probable source of excess sweat production in hyperhidrosis. In: Experimental Dermatology. 2011 ; Vol. 20, No. 12. pp. 1017–1020.
@article{2d4cf00150aa48f8a1411526f92b701b,
title = "The secretory clear cell of the eccrine sweat gland as the probable source of excess sweat production in hyperhidrosis",
abstract = "Primary hyperhidrosis is characterized by excessive sweating in palmar, plantar and axillary body regions. Gland hypertrophy and the existence of a third type of sweat gland, the apoeccrine gland, with high fluid transporting capabilities have been suggested as possible causes. This study investigated whether sweat glands were hypertrophied in axillary hyperhidrotic patients and if mechanisms associated with fluid transport were found in all types of axillary sweat glands. The occurrence of apoeccrine sweat glands was also investigated. Axillary skin biopsies from control and hyperhidrosis patients were examined using immunohistochemistry, image analysis and immunofluorescence microscopy.",
keywords = "eccrine sweat gland, hyperhidrosis, immunohistochemistry",
author = "Douglas Bovell and Alison MacDonald and Meyer, {Barbara A.} and Alistair Corbett and William MacLaren and Holmes, {Susan L.} and Mark Harker",
year = "2011",
month = "12",
doi = "10.1111/j.1600-0625.2011.01361.x",
language = "English",
volume = "20",
pages = "1017–1020",
journal = "Experimental Dermatology",
issn = "0906-6705",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "12",

}

Bovell, D, MacDonald, A, Meyer, BA, Corbett, A, MacLaren, W, Holmes, SL & Harker, M 2011, 'The secretory clear cell of the eccrine sweat gland as the probable source of excess sweat production in hyperhidrosis', Experimental Dermatology, vol. 20, no. 12, pp. 1017–1020. https://doi.org/10.1111/j.1600-0625.2011.01361.x

The secretory clear cell of the eccrine sweat gland as the probable source of excess sweat production in hyperhidrosis. / Bovell, Douglas; MacDonald, Alison; Meyer, Barbara A.; Corbett, Alistair; MacLaren, William; Holmes, Susan L.; Harker, Mark.

In: Experimental Dermatology, Vol. 20, No. 12, 12.2011, p. 1017–1020.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The secretory clear cell of the eccrine sweat gland as the probable source of excess sweat production in hyperhidrosis

AU - Bovell, Douglas

AU - MacDonald, Alison

AU - Meyer, Barbara A.

AU - Corbett, Alistair

AU - MacLaren, William

AU - Holmes, Susan L.

AU - Harker, Mark

PY - 2011/12

Y1 - 2011/12

N2 - Primary hyperhidrosis is characterized by excessive sweating in palmar, plantar and axillary body regions. Gland hypertrophy and the existence of a third type of sweat gland, the apoeccrine gland, with high fluid transporting capabilities have been suggested as possible causes. This study investigated whether sweat glands were hypertrophied in axillary hyperhidrotic patients and if mechanisms associated with fluid transport were found in all types of axillary sweat glands. The occurrence of apoeccrine sweat glands was also investigated. Axillary skin biopsies from control and hyperhidrosis patients were examined using immunohistochemistry, image analysis and immunofluorescence microscopy.

AB - Primary hyperhidrosis is characterized by excessive sweating in palmar, plantar and axillary body regions. Gland hypertrophy and the existence of a third type of sweat gland, the apoeccrine gland, with high fluid transporting capabilities have been suggested as possible causes. This study investigated whether sweat glands were hypertrophied in axillary hyperhidrotic patients and if mechanisms associated with fluid transport were found in all types of axillary sweat glands. The occurrence of apoeccrine sweat glands was also investigated. Axillary skin biopsies from control and hyperhidrosis patients were examined using immunohistochemistry, image analysis and immunofluorescence microscopy.

KW - eccrine sweat gland

KW - hyperhidrosis

KW - immunohistochemistry

UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-81455141244&partnerID=8YFLogxK

U2 - 10.1111/j.1600-0625.2011.01361.x

DO - 10.1111/j.1600-0625.2011.01361.x

M3 - Article

AN - SCOPUS:81455141244

VL - 20

SP - 1017

EP - 1020

JO - Experimental Dermatology

JF - Experimental Dermatology

SN - 0906-6705

IS - 12

ER -