The role of DNA methylation in expression and transmission of porcine endogenous retrovirus

Linda Scobie

doi:10.1128/JVI.03262-12

The role of DNA methylation in expression and transmission of porcine endogenous retrovirus

Linda Scobie

Biological and Biomedical Sciences

Research output: Contribution to journal › Article

Abstract

Porcine endogenous retroviruses (PERV) represent a major safety concern in pig-to-human xenotransplantation. To date, no PERV infection of a xenograft recipient has been recorded; however, PERVs are transmissible to human cells in vitro. Some recombinants of the A and C PERV subgroups are particularly efficient in infection and replication in human cells. Transcription of PERVs has been described in most pig cells, but their sequence and insertion polymorphism in the pig genome impede identification of transcriptionally active or silenced proviral copies.

Original language	English
Pages (from-to)	12110-12120
Number of pages	11
Journal	Journal of Virology
Volume	87
Issue number	22
Early online date	28 Aug 2013
DOIs	https://doi.org/10.1128/JVI.03262-12
Publication status	Published - Nov 2013

Keywords

DNA methylation
porcine endogenous retroviruses
xenotransplantation
genetics

Documents and Links

10.1128/JVI.03262-12

Publication in Scopus

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Scobie, L. (2013). The role of DNA methylation in expression and transmission of porcine endogenous retrovirus. Journal of Virology, 87(22), 12110-12120. https://doi.org/10.1128/JVI.03262-12

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