The role of DNA methylation in expression and transmission of porcine endogenous retrovirus

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Porcine endogenous retroviruses (PERV) represent a major safety concern in pig-to-human xenotransplantation. To date, no PERV infection of a xenograft recipient has been recorded; however, PERVs are transmissible to human cells in vitro. Some recombinants of the A and C PERV subgroups are particularly efficient in infection and replication in human cells. Transcription of PERVs has been described in most pig cells, but their sequence and insertion polymorphism in the pig genome impede identification of transcriptionally active or silenced proviral copies.
Original languageEnglish
Pages (from-to)12110-12120
Number of pages11
JournalJournal of Virology
Issue number22
Early online date28 Aug 2013
Publication statusPublished - Nov 2013



  • DNA methylation
  • porcine endogenous retroviruses
  • xenotransplantation
  • genetics

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