The Pro12Ala and C–681G variants of the PPARG locus are associated with opposing growth phenotypes in young schoolchildren

J. E. Cecil, B. Fischer, A. S. Doney, Marion Hetherington, P. Watt, W. Wrieden, C. Bolton-Smith, C. N. Palmer

Research output: Contribution to journalArticle

Abstract

Peroxisome proliferator-activated receptor ¿ is an important regulator of adiposity in mouse and man, and common variation in the PPARG gene has been associated with birthweight, adult obesity, insulin sensitivity and type 2 diabetes. We hypothesised that these variants may be associated with childhood obesity. Height and weight were recorded for 2454 prepubertal children aged between 4 and 10 years, who were then genotyped for three common variants of the PPARG locus: C–681G, Pro12Ala and C1431T.

Original languageEnglish
JournalDiabetologia
Publication statusPublished - 1 Jul 2005

Keywords

  • height
  • human genetics
  • obesity
  • PPARG locus

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    Cecil, J. E., Fischer, B., Doney, A. S., Hetherington, M., Watt, P., Wrieden, W., Bolton-Smith, C., & Palmer, C. N. (2005). The Pro12Ala and C–681G variants of the PPARG locus are associated with opposing growth phenotypes in young schoolchildren. Diabetologia. http://researchonline.gcu.ac.uk/sls/182