Peroxisome proliferator-activated receptor ¿ is an important regulator of adiposity in mouse and man, and common variation in the PPARG gene has been associated with birthweight, adult obesity, insulin sensitivity and type 2 diabetes. We hypothesised that these variants may be associated with childhood obesity. Height and weight were recorded for 2454 prepubertal children aged between 4 and 10 years, who were then genotyped for three common variants of the PPARG locus: C–681G, Pro12Ala and C1431T.
|Publication status||Published - 1 Jul 2005|
- human genetics
- PPARG locus