The prevalence and impact of thrombocytopenia, anaemia and leucopenia on sustained virological response in patients receiving hepatitis C therapy: evidence from a large ‘real world’ cohort

Huan Wang; Hamish Innes; Sharon Hutchinson; David Goldberg; Samuel Allen; Stephen T. Barclay; Peter Bramley; Raymond Fox; Andrew Fraser; Peter  Hayes; Nicholas Kennedy; Peter R. Mills; John F. Dillon

doi:10.1097/MEG.0000000000000556

The prevalence and impact of thrombocytopenia, anaemia and leucopenia on sustained virological response in patients receiving hepatitis C therapy: evidence from a large ‘real world’ cohort

Huan Wang, Hamish Innes, Sharon Hutchinson, David Goldberg, Samuel Allen, Stephen T. Barclay, Peter Bramley, Raymond Fox, Andrew Fraser, Peter Hayes, Nicholas Kennedy, Peter R. Mills, John F. Dillon

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Abstract

The aim of the study was to explore the extent of thrombocytopenia (TCP), anaemia and leucopenia in patients with hepatitis C and evaluate how they impact the management of antiviral therapy, the attainment of sustained virological response (SVR), and some therapy-related adverse events. The Scottish Hepatitis C Clinical Database was used in this retrospective study. The prevalence of TCP, anaemia and leucopenia was evaluated. The impact of the three deficiencies on antiviral therapy management, serious adverse events and SVR attainment was assessed in patients who received therapy.

Original language	English
Pages (from-to)	398-404
Number of pages	7
Journal	European Journal of Gastroenterology and Hepatology
Volume	28
Issue number	4
Early online date	21 Dec 2015
DOIs	https://doi.org/10.1097/MEG.0000000000000556
Publication status	Published - Apr 2016

Keywords

thrombocytopenia
Hepatitis C
antiviral therapy

Documents and Links

10.1097/MEG.0000000000000556

Wang, H et al (2016) European Journal of Gastroenterology and Hepatology article
This is an author final version of the article originally published in: European Journal of Gastroenterology and Hepatology (2016). The publisher version of this article is available via the DOI link below. Copyright © 2016 Lippincott, Williams & Wilkins.
Accepted author manuscript, 141 KB

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Wang, H., Innes, H., Hutchinson, S., Goldberg, D., Allen, S., Barclay, S. T., Bramley, P., Fox, R., Fraser, A., Hayes, P., Kennedy, N., Mills, P. R., & Dillon, J. F. (2016). The prevalence and impact of thrombocytopenia, anaemia and leucopenia on sustained virological response in patients receiving hepatitis C therapy: evidence from a large ‘real world’ cohort. European Journal of Gastroenterology and Hepatology, 28 (4), 398-404. https://doi.org/10.1097/MEG.0000000000000556

Wang, Huan ; Innes, Hamish ; Hutchinson, Sharon ; Goldberg, David ; Allen, Samuel ; Barclay, Stephen T. ; Bramley, Peter ; Fox, Raymond ; Fraser, Andrew ; Hayes, Peter ; Kennedy, Nicholas ; Mills, Peter R. ; Dillon, John F. / The prevalence and impact of thrombocytopenia, anaemia and leucopenia on sustained virological response in patients receiving hepatitis C therapy: evidence from a large ‘real world’ cohort. In: European Journal of Gastroenterology and Hepatology. 2016 ; Vol. 28 , No. 4. pp. 398-404.

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title = "The prevalence and impact of thrombocytopenia, anaemia and leucopenia on sustained virological response in patients receiving hepatitis C therapy: evidence from a large {\textquoteleft}real world{\textquoteright} cohort",

abstract = "The aim of the study was to explore the extent of thrombocytopenia (TCP), anaemia and leucopenia in patients with hepatitis C and evaluate how they impact the management of antiviral therapy, the attainment of sustained virological response (SVR), and some therapy-related adverse events. The Scottish Hepatitis C Clinical Database was used in this retrospective study. The prevalence of TCP, anaemia and leucopenia was evaluated. The impact of the three deficiencies on antiviral therapy management, serious adverse events and SVR attainment was assessed in patients who received therapy.",

keywords = "thrombocytopenia, Hepatitis C, antiviral therapy",

author = "Huan Wang and Hamish Innes and Sharon Hutchinson and David Goldberg and Samuel Allen and Barclay, {Stephen T.} and Peter Bramley and Raymond Fox and Andrew Fraser and Peter Hayes and Nicholas Kennedy and Mills, {Peter R.} and Dillon, {John F.}",

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Wang, H, Innes, H , Hutchinson, S , Goldberg, D, Allen, S, Barclay, ST, Bramley, P, Fox, R, Fraser, A, Hayes, P, Kennedy, N, Mills, PR & Dillon, JF 2016, 'The prevalence and impact of thrombocytopenia, anaemia and leucopenia on sustained virological response in patients receiving hepatitis C therapy: evidence from a large ‘real world’ cohort', European Journal of Gastroenterology and Hepatology, vol. 28 , no. 4, pp. 398-404. https://doi.org/10.1097/MEG.0000000000000556

The prevalence and impact of thrombocytopenia, anaemia and leucopenia on sustained virological response in patients receiving hepatitis C therapy: evidence from a large ‘real world’ cohort. / Wang, Huan; Innes, Hamish ; Hutchinson, Sharon ; Goldberg, David; Allen, Samuel; Barclay, Stephen T.; Bramley, Peter; Fox, Raymond; Fraser, Andrew; Hayes, Peter ; Kennedy, Nicholas; Mills, Peter R.; Dillon, John F.

In: European Journal of Gastroenterology and Hepatology, Vol. 28 , No. 4, 04.2016, p. 398-404.

Research output: Contribution to journal › Article

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AU - Wang, Huan

AU - Innes, Hamish

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AU - Goldberg, David

AU - Allen, Samuel

AU - Barclay, Stephen T.

AU - Bramley, Peter

AU - Fox, Raymond

AU - Fraser, Andrew

AU - Hayes, Peter

AU - Kennedy, Nicholas

AU - Mills, Peter R.

AU - Dillon, John F.

N1 - Out-with REF monitoring period (online pub Dec15) Acceptance date unknown AAM uploaded 9-3-16; 12m embargo required by publisher applied to online pub date - ET 18-4-16

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AB - The aim of the study was to explore the extent of thrombocytopenia (TCP), anaemia and leucopenia in patients with hepatitis C and evaluate how they impact the management of antiviral therapy, the attainment of sustained virological response (SVR), and some therapy-related adverse events. The Scottish Hepatitis C Clinical Database was used in this retrospective study. The prevalence of TCP, anaemia and leucopenia was evaluated. The impact of the three deficiencies on antiviral therapy management, serious adverse events and SVR attainment was assessed in patients who received therapy.

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KW - Hepatitis C

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Wang H, Innes H , Hutchinson S , Goldberg D, Allen S, Barclay ST et al. The prevalence and impact of thrombocytopenia, anaemia and leucopenia on sustained virological response in patients receiving hepatitis C therapy: evidence from a large ‘real world’ cohort. European Journal of Gastroenterology and Hepatology. 2016 Apr;28 (4):398-404. https://doi.org/10.1097/MEG.0000000000000556