The pathobiology of Paracoccidioides brasiliensis

M. Ines Borges-Walmsley, Daliang Chen, Xinhua Shu, Adrian R. Walmsley

Research output: Contribution to journalArticle

Abstract

Paracoccidioides brasiliensis causes one of the most prevalent systemic mycoses in Latin America – paracoccidioidomycosis. It is a dimorphic fungus that undergoes a complex transformation in vivo, with mycelia in the environment producing conidia, which probably act as infectious propagules upon inhalation into the lungs, where they transform to the pathogenic yeast form. This transition is readily induced in vitro by temperature changes, resulting in modulation of the composition of the cell wall. Notably, the polymer linkages change from ß-glucan to a-glucan, possibly to avoid ß-glucan triggering the inflammatory response. Mammalian oestrogens inhibit this transition, giving rise to a higher incidence of disease in males. Furthermore, the susceptibility of individuals to paracoccidioidomycosis has a genetic basis, which results in a depressed cellular immune response in susceptible patients; resistance is conferred by cytokine-stimulated granuloma formation and nitric oxide production. The latency period and persistence of the disease and the apparent lack of efficacy of humoral immunity are consistent with P. brasiliensis existing as a facultative intracellular pathogen.
Original languageEnglish
Pages (from-to)80-87
JournalTrends in Microbiology
Volume10
Issue number2
DOIs
Publication statusPublished - 1 Feb 2002

Keywords

  • Paracoccidioides brasiliensis
  • fungal virulence
  • mycosis
  • fungal pathogenesis
  • dimorphic

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