The oral mucosa-fungi interactome

Prasanna Neelakantan; Shanthini Kalimuthu; Akhila Pudipeddi; Bastiaan P. Krom; Gordon Ramage; Mark Butcher; Jason L. Brown

doi:10.1007/978-3-031-82202-5_7

The oral mucosa-fungi interactome

Prasanna Neelakantan^*
, Shanthini Kalimuthu
, Akhila Pudipeddi
, Bastiaan P. Krom
, Gordon Ramage
, Mark Butcher
, Jason L. Brown

^*Corresponding author for this work

Nursing

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

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Abstract

Human beings are indwelled by a wide array of cellular microbes, building up their core microbiome. Amongst these, bacterial constituents comprise about 99% of the population. The remaining small, yet diverse population of microbes are termed the ‘rare-biosphere’. The eukaryotic yeasts contribute a substantial population within the rare biosphere. Despite the reduced abundance, yeasts/fungi cause a wide range of infections ranging from superficial to deep-seated, invasive, and life-threatening infections. This chapter provides an in-depth view of the role of fungi, specifically Candida albicans, in oral health and disease. We highlight the interactive profiles between the mycobiome and host oral tissues including study models for future state-of-the-art research in this important area.

Original language	English
Title of host publication	Oral Biofilms in Health and Disease
Editors	Hyun (Michel) Koo, Nicholas S. Jakubovics, Bastiaan P. Krom
Publisher	Springer, Cham
Chapter	8
Pages	189–231
Number of pages	42
ISBN (Electronic)	9783031822025
ISBN (Print)	9783031822018
DOIs	https://doi.org/10.1007/978-3-031-82202-5_7
Publication status	Published - 31 May 2025

Publication series

Name	Springer Series on Biofilms
Volume	14
ISSN (Print)	1863-9607
ISSN (Electronic)	1863-9615

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1007/978-3-031-82202-5_7

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title = "The oral mucosa-fungi interactome",

abstract = "Human beings are indwelled by a wide array of cellular microbes, building up their core microbiome. Amongst these, bacterial constituents comprise about 99\% of the population. The remaining small, yet diverse population of microbes are termed the {\textquoteleft}rare-biosphere{\textquoteright}. The eukaryotic yeasts contribute a substantial population within the rare biosphere. Despite the reduced abundance, yeasts/fungi cause a wide range of infections ranging from superficial to deep-seated, invasive, and life-threatening infections. This chapter provides an in-depth view of the role of fungi, specifically Candida albicans, in oral health and disease. We highlight the interactive profiles between the mycobiome and host oral tissues including study models for future state-of-the-art research in this important area.",

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The oral mucosa-fungi interactome. / Neelakantan, Prasanna; Kalimuthu, Shanthini; Pudipeddi, Akhila et al.
Oral Biofilms in Health and Disease. ed. / Hyun (Michel) Koo; Nicholas S. Jakubovics; Bastiaan P. Krom. Springer, Cham, 2025. p. 189–231 (Springer Series on Biofilms; Vol. 14).

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

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T1 - The oral mucosa-fungi interactome

AU - Neelakantan, Prasanna

AU - Kalimuthu, Shanthini

AU - Pudipeddi, Akhila

AU - Krom, Bastiaan P.

AU - Ramage, Gordon

AU - Butcher, Mark

AU - Brown, Jason L.

PY - 2025/5/31

Y1 - 2025/5/31

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AB - Human beings are indwelled by a wide array of cellular microbes, building up their core microbiome. Amongst these, bacterial constituents comprise about 99% of the population. The remaining small, yet diverse population of microbes are termed the ‘rare-biosphere’. The eukaryotic yeasts contribute a substantial population within the rare biosphere. Despite the reduced abundance, yeasts/fungi cause a wide range of infections ranging from superficial to deep-seated, invasive, and life-threatening infections. This chapter provides an in-depth view of the role of fungi, specifically Candida albicans, in oral health and disease. We highlight the interactive profiles between the mycobiome and host oral tissues including study models for future state-of-the-art research in this important area.

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SN - 9783031822018

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BT - Oral Biofilms in Health and Disease

A2 - Koo, Hyun (Michel)

A2 - Jakubovics, Nicholas S.

A2 - Krom, Bastiaan P.

PB - Springer, Cham

ER -

The oral mucosa-fungi interactome

Abstract

Publication series

UN SDGs

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