The influence of tigecycline on the expression of virulence factors in biofilm associated cells of methicillin resistant Staphylococcus aureus

Karen Smith; Katherine A. Gould; Gordon Ramage; Curtis G. Gemmell; Jason Hinds; Sue Lang

doi:10.1128/AAC.00155-09

The influence of tigecycline on the expression of virulence factors in biofilm associated cells of methicillin resistant Staphylococcus aureus

Karen Smith, Katherine A. Gould, Gordon Ramage, Curtis G. Gemmell, Jason Hinds, Sue Lang

Biological and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) infections are complicated by the ability of the organism to grow in surface-adhered biofilms on a multitude of abiotic and biological surfaces. These multicellular communities are notoriously difficult to eradicate with antimicrobial therapy. Cells within the biofilm may be exposed to a sublethal concentration of the antimicrobial due to the metabolic and phenotypic diversity of the biofilm-associated cells or the protection offered by the biofilm structure. In the present study, the influence of a sublethal concentration of tigecycline on biofilms formed by an epidemic MRSA-16 isolate was investigated by transcriptome analysis.

Original language	English
Pages (from-to)	380-387
Number of pages	8
Journal	Antimicrobial Agents and Chemotherapy
Volume	54
Issue number	1
DOIs	https://doi.org/10.1128/AAC.00155-09
Publication status	Published - 1 Jan 2010

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10.1128/AAC.00155-09

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title = "The influence of tigecycline on the expression of virulence factors in biofilm associated cells of methicillin resistant Staphylococcus aureus",

abstract = "Methicillin-resistant Staphylococcus aureus (MRSA) infections are complicated by the ability of the organism to grow in surface-adhered biofilms on a multitude of abiotic and biological surfaces. These multicellular communities are notoriously difficult to eradicate with antimicrobial therapy. Cells within the biofilm may be exposed to a sublethal concentration of the antimicrobial due to the metabolic and phenotypic diversity of the biofilm-associated cells or the protection offered by the biofilm structure. In the present study, the influence of a sublethal concentration of tigecycline on biofilms formed by an epidemic MRSA-16 isolate was investigated by transcriptome analysis.",

author = "Karen Smith and Gould, {Katherine A.} and Gordon Ramage and Gemmell, {Curtis G.} and Jason Hinds and Sue Lang",

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The influence of tigecycline on the expression of virulence factors in biofilm associated cells of methicillin resistant Staphylococcus aureus. / Smith, Karen; Gould, Katherine A.; Ramage, Gordon; Gemmell, Curtis G.; Hinds, Jason; Lang, Sue.

In: Antimicrobial Agents and Chemotherapy, Vol. 54, No. 1, 01.01.2010, p. 380-387.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The influence of tigecycline on the expression of virulence factors in biofilm associated cells of methicillin resistant Staphylococcus aureus

AU - Smith, Karen

AU - Gould, Katherine A.

AU - Ramage, Gordon

AU - Gemmell, Curtis G.

AU - Hinds, Jason

AU - Lang, Sue

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PY - 2010/1/1

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AB - Methicillin-resistant Staphylococcus aureus (MRSA) infections are complicated by the ability of the organism to grow in surface-adhered biofilms on a multitude of abiotic and biological surfaces. These multicellular communities are notoriously difficult to eradicate with antimicrobial therapy. Cells within the biofilm may be exposed to a sublethal concentration of the antimicrobial due to the metabolic and phenotypic diversity of the biofilm-associated cells or the protection offered by the biofilm structure. In the present study, the influence of a sublethal concentration of tigecycline on biofilms formed by an epidemic MRSA-16 isolate was investigated by transcriptome analysis.

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JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

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The influence of tigecycline on the expression of virulence factors in biofilm associated cells of methicillin resistant Staphylococcus aureus

Abstract

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