The influence of tigecycline on the expression of virulence factors in biofilm associated cells of methicillin resistant Staphylococcus aureus

Karen Smith, Katherine A. Gould, Gordon Ramage, Curtis G. Gemmell, Jason Hinds, Sue Lang

Research output: Contribution to journalArticle

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) infections are complicated by the ability of the organism to grow in surface-adhered biofilms on a multitude of abiotic and biological surfaces. These multicellular communities are notoriously difficult to eradicate with antimicrobial therapy. Cells within the biofilm may be exposed to a sublethal concentration of the antimicrobial due to the metabolic and phenotypic diversity of the biofilm-associated cells or the protection offered by the biofilm structure. In the present study, the influence of a sublethal concentration of tigecycline on biofilms formed by an epidemic MRSA-16 isolate was investigated by transcriptome analysis.

Original languageEnglish
Pages (from-to)380-387
Number of pages8
JournalAntimicrobial Agents and Chemotherapy
Volume54
Issue number1
DOIs
Publication statusPublished - 1 Jan 2010

Fingerprint Dive into the research topics of 'The influence of tigecycline on the expression of virulence factors in biofilm associated cells of methicillin resistant Staphylococcus aureus'. Together they form a unique fingerprint.

Cite this