Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) infections are complicated by the ability of the organism to grow in surface-adhered biofilms on a multitude of abiotic and biological surfaces. These multicellular communities are notoriously difficult to eradicate with antimicrobial therapy. Cells within the biofilm may be exposed to a sublethal concentration of the antimicrobial due to the metabolic and phenotypic diversity of the biofilm-associated cells or the protection offered by the biofilm structure. In the present study, the influence of a sublethal concentration of tigecycline on biofilms formed by an epidemic MRSA-16 isolate was investigated by transcriptome analysis.
Original language | English |
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Pages (from-to) | 380-387 |
Number of pages | 8 |
Journal | Antimicrobial Agents and Chemotherapy |
Volume | 54 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Jan 2010 |