The influence of gender on the development of pulmonary arterial hypertension

Yvonne Dempsie, Margaret R. MacLean

Research output: Contribution to journalLiterature review

Abstract

Pulmonary arterial hypertension (PAH) in its idiopathic and familial forms occurs more frequently in females than in males (>2:1 incidence ratio). Experimentally, however, female gender and oestrogens can both protect against and exacerbate PAH. This review will discuss our current understanding of the influence of sex hormones on the development of PAH.
Original languageEnglish
Pages (from-to)1257-1261
Number of pages5
JournalExperimental Physiology
Volume98
Early online date26 Apr 2013
DOIs
Publication statusPublished - Aug 2013

Fingerprint

Pulmonary Hypertension
Gonadal Steroid Hormones
Estrogens
Incidence

Keywords

  • pulmonary arterial hypertension
  • PAH
  • oestrogens
  • sex hormones

Cite this

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The influence of gender on the development of pulmonary arterial hypertension. / Dempsie, Yvonne; MacLean, Margaret R.

In: Experimental Physiology, Vol. 98, 08.2013, p. 1257-1261.

Research output: Contribution to journalLiterature review

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AB - Pulmonary arterial hypertension (PAH) in its idiopathic and familial forms occurs more frequently in females than in males (>2:1 incidence ratio). Experimentally, however, female gender and oestrogens can both protect against and exacerbate PAH. This review will discuss our current understanding of the influence of sex hormones on the development of PAH.

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KW - oestrogens

KW - sex hormones

U2 - 10.1113/expphysiol.2012.069120

DO - 10.1113/expphysiol.2012.069120

M3 - Literature review

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