The influence of gender on the development of pulmonary arterial hypertension

Yvonne Dempsie; Margaret R. MacLean

doi:10.1113/expphysiol.2012.069120

The influence of gender on the development of pulmonary arterial hypertension

Yvonne Dempsie, Margaret R. MacLean

Biological and Biomedical Sciences

Research output: Contribution to journal › Literature review › peer-review

Abstract

Pulmonary arterial hypertension (PAH) in its idiopathic and familial forms occurs more frequently in females than in males (>2:1 incidence ratio). Experimentally, however, female gender and oestrogens can both protect against and exacerbate PAH. This review will discuss our current understanding of the influence of sex hormones on the development of PAH.

Original language	English
Pages (from-to)	1257-1261
Number of pages	5
Journal	Experimental Physiology
Volume	98
Early online date	26 Apr 2013
DOIs	https://doi.org/10.1113/expphysiol.2012.069120
Publication status	Published - Aug 2013

Keywords

pulmonary arterial hypertension
PAH
oestrogens
sex hormones

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10.1113/expphysiol.2012.069120

Cite this

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abstract = "Pulmonary arterial hypertension (PAH) in its idiopathic and familial forms occurs more frequently in females than in males (>2:1 incidence ratio). Experimentally, however, female gender and oestrogens can both protect against and exacerbate PAH. This review will discuss our current understanding of the influence of sex hormones on the development of PAH. ",

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AB - Pulmonary arterial hypertension (PAH) in its idiopathic and familial forms occurs more frequently in females than in males (>2:1 incidence ratio). Experimentally, however, female gender and oestrogens can both protect against and exacerbate PAH. This review will discuss our current understanding of the influence of sex hormones on the development of PAH.

KW - pulmonary arterial hypertension

KW - PAH

KW - oestrogens

KW - sex hormones

U2 - 10.1113/expphysiol.2012.069120

DO - 10.1113/expphysiol.2012.069120

M3 - Literature review

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JO - Experimental Physiology

JF - Experimental Physiology

SN - 0958-0670

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The influence of gender on the development of pulmonary arterial hypertension

Abstract

Keywords

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