The in vivo effects of human urotensin II in the rabbit and rat pulmonary circulation: Effects of experimental pulmonary hypertension

Graeme A Deuchar, Ian Morecroft, Yvonne Dempsie, Nigel Herold, Margaret Nilsen, Martin N Hicks, Margaret R MacLean

Research output: Contribution to journalArticle

Abstract

In vivo haemodynamic responses to human urotensin-II were determined in two models of pulmonary hypertension: rabbits with left ventricular dysfunction following coronary artery ligation and the hypoxic rat. Effects were also examined in the presence of the nitric oxide synthase inhibitor N¿-nitro-l-arginine methyl ester (l-NAME). Human urotensin-II increased pulmonary arterial pressure to a greater extent in ligated rabbits than their controls and l-NAME increased pulmonary pressure without significantly affecting these responses to human urotensin-II. Human urotensin-II raised right ventricular pressure slightly in control rats but not in hypoxic rats. Human urotensin-II did not constrict control rat isolated small pulmonary arteries and only induced a small constriction of these vessels in hypoxic rats. In conclusion, exogenous human urotensin-II exerts pulmonary pressor responses in vivo in rabbits and also induced small pulmonary pressor responses in control rats. Pulmonary pressor responses to urotensin-II were increased by pulmonary hypertension in rabbits but not in rats.
Original languageEnglish
Pages (from-to)135-42
Number of pages8
JournalEuropean Journal of Pharmacology
Volume537
Issue number1-3
Early online date17 Mar 2006
DOIs
Publication statusPublished - May 2006

Keywords

  • pulmonary circulation
  • blood pressure
  • Urotensin II
  • hypoxia
  • hypertension

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