Abstract
Background: Falls among elderly people is a major issue in public health, causing debilitating outcomes including fracture. The identification of genetic risk factors for falling may provide a strategy for effectively targeting falls prevention programs. We investigated whether a common functional variant of skeletal muscle a-actinin-3 (ACTN3 p. R577X) previously associated with impairments in muscle strength, power, and physical functioning represents a risk factor for falls. Methods: Case-control analysis was conducted using two large cohorts of Caucasian postmenopausal women-the North of Scotland Osteoporosis Study (n = 1,245) and the Aberdeen Prospective Osteoporosis Screening Study (n = 2,918)-for whom self-reported falls status and DNA samples were available. Cross-sectional analysis of fallers versus nonfallers at baseline and follow-up was performed. In addition, individuals who reported having fallen at more than one timepoint (recurrent fallers) were compared with those who reported not falling at any timepoint. Results: Association between R577X genotype and falls was identified and validated. Carriage of 577X (one or two copies) was significantly associated with a 33% (10%-61%) increased risk of falling, with the effect apparent at both baseline and follow-up assessments (meta-analysis p =.003 and p =.02, respectively). No significant effect on recurrent falls was observed. Conclusion: This study reports for the first time that the functional ACTN3 R577X genotype represents a genetic risk factor for falling in older females.
Original language | English |
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Pages (from-to) | 130-135 |
Number of pages | 6 |
Journal | Journals of Gerontology - Series A Biological Sciences and Medical Sciences |
Volume | 66 A |
Issue number | 1 |
Early online date | 21 Oct 2010 |
DOIs | |
Publication status | Published - Jan 2011 |
Keywords
- ACTN3
- falls
- genetic association
- skeletal muscle
ASJC Scopus subject areas
- Ageing
- Geriatrics and Gerontology