The effect of cycling using active-passive trainers on spasticity, cardiovascular fitness, function and quality of life in people with moderate to severe Multiple Sclerosis (MS): a feasibility study.

A. Barclay, L. Paul, N. MacFarlane, A.K. McFadyen

Research output: Contribution to journalArticle

Abstract

Background: Exercise options for those with moderate to high levels of disability are limited. The aim of the study was to evaluate the feasibility of a progressive, four week lower limb cycling programme using active-passive trainers (APT's) on spasticity, cardiovascular fitness, function and quality of life in people with moderate to severe MS. Methods: Participants were in-patients in the Physical Disability Rehabilitation Unit, Queen Elizabeth University Hospital, Glasgow, UK and randomised to APT + usual care or usual care only. The APT group received 30 min of APT (2 min passive warm up, 26 min active cycling, 2 min passive cool down), five days per week for 4 weeks. Outcome measures; Oxygen Uptake Efficiency Slope, Modified Ashworth Scale, Multiple Sclerosis Spasticity Scale, Functional Independence Measure, Timed 25 foot walk test and the MSQOL-54, were taken before and after the intervention period. Symmetry, distance cycled and active participation were also recorded for each cycling session. Results: 24 participants were recruited, 15 to the intervention and 9 to the control group. There was a 100% adherence to the intervention and a significant increase in average speed, power output and distance cycled (p <0.001 for each) over the four weeks. There were no adverse events and both groups improved in average scores for all outcome measures. Conclusions: APT cycling was well tolerated, while the cycling parameters improved it was difficult to separate the effects of the therapy programme and APT cycling. A longer duration, fully powered trial in a community setting is merited.
Original languageEnglish
Pages (from-to)128-134
Number of pages7
JournalMultiple Sclerosis and Related Disorders
Volume34
Early online date18 Jun 2019
DOIs
Publication statusPublished - Sep 2019

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Feasibility Studies
Multiple Sclerosis
Quality of Life
Outcome Assessment (Health Care)
Lower Extremity
Rehabilitation
Exercise
Oxygen
Control Groups
Therapeutics
Walk Test

Keywords

  • cycling
  • active-passive trainers
  • MS
  • exercise
  • spasticity

Cite this

@article{4434463979144bc7add1787effe53e61,
title = "The effect of cycling using active-passive trainers on spasticity, cardiovascular fitness, function and quality of life in people with moderate to severe Multiple Sclerosis (MS): a feasibility study.",
abstract = "Background: Exercise options for those with moderate to high levels of disability are limited. The aim of the study was to evaluate the feasibility of a progressive, four week lower limb cycling programme using active-passive trainers (APT's) on spasticity, cardiovascular fitness, function and quality of life in people with moderate to severe MS. Methods: Participants were in-patients in the Physical Disability Rehabilitation Unit, Queen Elizabeth University Hospital, Glasgow, UK and randomised to APT + usual care or usual care only. The APT group received 30 min of APT (2 min passive warm up, 26 min active cycling, 2 min passive cool down), five days per week for 4 weeks. Outcome measures; Oxygen Uptake Efficiency Slope, Modified Ashworth Scale, Multiple Sclerosis Spasticity Scale, Functional Independence Measure, Timed 25 foot walk test and the MSQOL-54, were taken before and after the intervention period. Symmetry, distance cycled and active participation were also recorded for each cycling session. Results: 24 participants were recruited, 15 to the intervention and 9 to the control group. There was a 100{\%} adherence to the intervention and a significant increase in average speed, power output and distance cycled (p <0.001 for each) over the four weeks. There were no adverse events and both groups improved in average scores for all outcome measures. Conclusions: APT cycling was well tolerated, while the cycling parameters improved it was difficult to separate the effects of the therapy programme and APT cycling. A longer duration, fully powered trial in a community setting is merited.",
keywords = "cycling, active-passive trainers, MS, exercise, spasticity",
author = "A. Barclay and L. Paul and N. MacFarlane and A.K. McFadyen",
note = "Acceptance in SAN/ from webpage AAM: 12m embargo",
year = "2019",
month = "9",
doi = "10.1016/j.msard.2019.06.019",
language = "English",
volume = "34",
pages = "128--134",
journal = "Multiple Sclerosis and Related Disorders",
issn = "2211-0348",
publisher = "Elsevier B.V.",

}

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T1 - The effect of cycling using active-passive trainers on spasticity, cardiovascular fitness, function and quality of life in people with moderate to severe Multiple Sclerosis (MS): a feasibility study.

AU - Barclay, A.

AU - Paul, L.

AU - MacFarlane, N.

AU - McFadyen, A.K.

N1 - Acceptance in SAN/ from webpage AAM: 12m embargo

PY - 2019/9

Y1 - 2019/9

N2 - Background: Exercise options for those with moderate to high levels of disability are limited. The aim of the study was to evaluate the feasibility of a progressive, four week lower limb cycling programme using active-passive trainers (APT's) on spasticity, cardiovascular fitness, function and quality of life in people with moderate to severe MS. Methods: Participants were in-patients in the Physical Disability Rehabilitation Unit, Queen Elizabeth University Hospital, Glasgow, UK and randomised to APT + usual care or usual care only. The APT group received 30 min of APT (2 min passive warm up, 26 min active cycling, 2 min passive cool down), five days per week for 4 weeks. Outcome measures; Oxygen Uptake Efficiency Slope, Modified Ashworth Scale, Multiple Sclerosis Spasticity Scale, Functional Independence Measure, Timed 25 foot walk test and the MSQOL-54, were taken before and after the intervention period. Symmetry, distance cycled and active participation were also recorded for each cycling session. Results: 24 participants were recruited, 15 to the intervention and 9 to the control group. There was a 100% adherence to the intervention and a significant increase in average speed, power output and distance cycled (p <0.001 for each) over the four weeks. There were no adverse events and both groups improved in average scores for all outcome measures. Conclusions: APT cycling was well tolerated, while the cycling parameters improved it was difficult to separate the effects of the therapy programme and APT cycling. A longer duration, fully powered trial in a community setting is merited.

AB - Background: Exercise options for those with moderate to high levels of disability are limited. The aim of the study was to evaluate the feasibility of a progressive, four week lower limb cycling programme using active-passive trainers (APT's) on spasticity, cardiovascular fitness, function and quality of life in people with moderate to severe MS. Methods: Participants were in-patients in the Physical Disability Rehabilitation Unit, Queen Elizabeth University Hospital, Glasgow, UK and randomised to APT + usual care or usual care only. The APT group received 30 min of APT (2 min passive warm up, 26 min active cycling, 2 min passive cool down), five days per week for 4 weeks. Outcome measures; Oxygen Uptake Efficiency Slope, Modified Ashworth Scale, Multiple Sclerosis Spasticity Scale, Functional Independence Measure, Timed 25 foot walk test and the MSQOL-54, were taken before and after the intervention period. Symmetry, distance cycled and active participation were also recorded for each cycling session. Results: 24 participants were recruited, 15 to the intervention and 9 to the control group. There was a 100% adherence to the intervention and a significant increase in average speed, power output and distance cycled (p <0.001 for each) over the four weeks. There were no adverse events and both groups improved in average scores for all outcome measures. Conclusions: APT cycling was well tolerated, while the cycling parameters improved it was difficult to separate the effects of the therapy programme and APT cycling. A longer duration, fully powered trial in a community setting is merited.

KW - cycling

KW - active-passive trainers

KW - MS

KW - exercise

KW - spasticity

U2 - 10.1016/j.msard.2019.06.019

DO - 10.1016/j.msard.2019.06.019

M3 - Article

VL - 34

SP - 128

EP - 134

JO - Multiple Sclerosis and Related Disorders

JF - Multiple Sclerosis and Related Disorders

SN - 2211-0348

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