The determination of biogenic amines in four strains of the fruit fly Drosophila melanogaster

D. G. Watson*, P. Zhou, J. M. Midgley, C. D. Milligan, K. Kaiser

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

A range of biogenic amines were measured in the heads from four strains of Drosophila melanogaster. Quantitation was carried out using gas chromatography-negative ion chemical ionization mass spectrometry (GC-NICIMS) with stable isotope dilution. The principal amines detected in the heads were dopamine, noradrenaline and 5 HT with small amounts of p- and m-tyramine; p-octopamine could not be detected in samples of 25 heads with a limit of detection of 10 pg per sample. In addition to conventional neurotransmitters or putative neurotransmitters the amines 5- and 6-hydroxydopamine were detected in the heads in substantial amounts.

Original languageEnglish
Pages (from-to)1145-1149
Number of pages5
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume11
Issue number11-12
DOIs
Publication statusPublished - 1993
Externally publishedYes

Keywords

  • dopamine
  • Drosophila
  • Gas chromatography-mass spectrometry
  • hydroxydopamines
  • noradrenaline

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmaceutical Science
  • Drug Discovery
  • Spectroscopy
  • Clinical Biochemistry

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