The connexin mimetic peptide Gap27 increases human dermal fibroblast migration in hyperglycemic and hyperinsulinemic conditions in vitro

Catherine Wright, Simone Pollok, David J. Flint, Johanna M. Brandner, Patricia Martin

Research output: Contribution to journalArticle

Abstract

Significant increases in skin wound healing rates occur by reducing connexin-mediated communication (CMC). Gap27, a connexin (Cx) mimetic peptide targeted to the second extracellular loop of Cx43, which inhibits CMC, increases migration of human keratinocytes and dermal fibroblasts. To examine the efficacy of Gap27 in a hyperglycemic and hyperinsulinemic in vitro environment, cell migration, gap junction, and Cx hemichannel functionality and cell-substrate adhesion assays were performed on human dermal fibroblasts and diabetic fibroblast and keratinocytes.



Original languageEnglish
Pages (from-to)77-87
Number of pages11
JournalJournal of Cellular Physiology
Volume227
Issue number1
Early online date24 Oct 2011
DOIs
Publication statusPublished - Jan 2012

Keywords

  • Gap 27
  • connexin
  • wound healing

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