The connexin mimetic peptide Gap27 improves cell motility in human skin models despite raised glucose, insulin and IGFBP-5

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In chronic non-healing diabetic wounds Connexin43 (Cx43) is upregulated at the wound edge compared to ‘normal’ skin wounds. Reduced Cx43 expression/function is associated with improved wound closure rates, consistent with our data to date showing that the Cx43 channel blocker, Gap27, increases scrape-wound closure rates in human skin models. Insulin Growth Factor-I (IGF-I) also stimulates skin wound healing whilst its actions can be attenuated by IGF binding protein 5 (IGFBP-5). The IGF-I:IGFBP-5 ratio is altered in diabetic skin and maybe of clinical significance.
Original languageEnglish
Title of host publicationJournal of Investigative Dermatology
PagesS9
Number of pages1
Volume132
Publication statusPublished - 7 Sep 2012

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Keywords

  • connexin
  • wound healing
  • diabetes
  • Gap 27
  • IGFBP-5

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