The connexin mimetic peptide Gap27 improves cell motility in human skin models despite raised glucose, insulin and IGFBP-5

Catherine Sarah Wright; David J  Flint; Patricia Martin

The connexin mimetic peptide Gap27 improves cell motility in human skin models despite raised glucose, insulin and IGFBP-5

Catherine Sarah Wright, David J Flint, Patricia Martin

Biological and Biomedical Sciences

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

In chronic non-healing diabetic wounds Connexin43 (Cx43) is upregulated at the wound edge compared to ‘normal’ skin wounds. Reduced Cx43 expression/function is associated with improved wound closure rates, consistent with our data to date showing that the Cx43 channel blocker, Gap27, increases scrape-wound closure rates in human skin models. Insulin Growth Factor-I (IGF-I) also stimulates skin wound healing whilst its actions can be attenuated by IGF binding protein 5 (IGFBP-5). The IGF-I:IGFBP-5 ratio is altered in diabetic skin and maybe of clinical significance.

Original language	English
Title of host publication	Journal of Investigative Dermatology
Pages	S9
Number of pages	1
Volume	132
Publication status	Published - 7 Sept 2012

Keywords

connexin
wound healing
diabetes
Gap 27
IGFBP-5

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Documents and Links

http://www.sciencedirect.com/science/article/pii/S0022202X15359224

Cite this

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title = "The connexin mimetic peptide Gap27 improves cell motility in human skin models despite raised glucose, insulin and IGFBP-5",

abstract = "In chronic non-healing diabetic wounds Connexin43 (Cx43) is upregulated at the wound edge compared to {\textquoteleft}normal{\textquoteright} skin wounds. Reduced Cx43 expression/function is associated with improved wound closure rates, consistent with our data to date showing that the Cx43 channel blocker, Gap27, increases scrape-wound closure rates in human skin models. Insulin Growth Factor-I (IGF-I) also stimulates skin wound healing whilst its actions can be attenuated by IGF binding protein 5 (IGFBP-5). The IGF-I:IGFBP-5 ratio is altered in diabetic skin and maybe of clinical significance.",

keywords = "connexin, wound healing, diabetes, Gap 27, IGFBP-5",

author = "Wright, {Catherine Sarah} and Flint, {David J} and Patricia Martin",

year = "2012",

month = sep,

day = "7",

language = "English",

volume = "132",

pages = "S9",

booktitle = "Journal of Investigative Dermatology",

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TY - GEN

T1 - The connexin mimetic peptide Gap27 improves cell motility in human skin models despite raised glucose, insulin and IGFBP-5

AU - Wright, Catherine Sarah

AU - Flint, David J

AU - Martin, Patricia

PY - 2012/9/7

Y1 - 2012/9/7

N2 - In chronic non-healing diabetic wounds Connexin43 (Cx43) is upregulated at the wound edge compared to ‘normal’ skin wounds. Reduced Cx43 expression/function is associated with improved wound closure rates, consistent with our data to date showing that the Cx43 channel blocker, Gap27, increases scrape-wound closure rates in human skin models. Insulin Growth Factor-I (IGF-I) also stimulates skin wound healing whilst its actions can be attenuated by IGF binding protein 5 (IGFBP-5). The IGF-I:IGFBP-5 ratio is altered in diabetic skin and maybe of clinical significance.

AB - In chronic non-healing diabetic wounds Connexin43 (Cx43) is upregulated at the wound edge compared to ‘normal’ skin wounds. Reduced Cx43 expression/function is associated with improved wound closure rates, consistent with our data to date showing that the Cx43 channel blocker, Gap27, increases scrape-wound closure rates in human skin models. Insulin Growth Factor-I (IGF-I) also stimulates skin wound healing whilst its actions can be attenuated by IGF binding protein 5 (IGFBP-5). The IGF-I:IGFBP-5 ratio is altered in diabetic skin and maybe of clinical significance.

KW - connexin

KW - wound healing

KW - diabetes

KW - Gap 27

KW - IGFBP-5

M3 - Conference contribution

VL - 132

SP - S9

BT - Journal of Investigative Dermatology

ER -

The connexin mimetic peptide Gap27 improves cell motility in human skin models despite raised glucose, insulin and IGFBP-5

Abstract

Keywords

UN SDGs

Documents and Links

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Cite this