In chronic non-healing diabetic wounds Connexin43 (Cx43) is upregulated at the wound edge compared to ‘normal’ skin wounds. Reduced Cx43 expression/function is associated with improved wound closure rates, consistent with our data to date showing that the Cx43 channel blocker, Gap27, increases scrape-wound closure rates in human skin models. Insulin Growth Factor-I (IGF-I) also stimulates skin wound healing whilst its actions can be attenuated by IGF binding protein 5 (IGFBP-5). The IGF-I:IGFBP-5 ratio is altered in diabetic skin and maybe of clinical significance.
|Title of host publication||Journal of Investigative Dermatology|
|Number of pages||1|
|Publication status||Published - 7 Sep 2012|
- wound healing
- Gap 27
Wright, C. S., Flint, D. J., & Martin, P. (2012). The connexin mimetic peptide Gap27 improves cell motility in human skin models despite raised glucose, insulin and IGFBP-5. In Journal of Investigative Dermatology (Vol. 132, pp. S9). [048 ] http://www.sciencedirect.com/science/article/pii/S0022202X15359224