The comparative efficacy of antiseptics against Candida auris biofilms

Ryan Kean, Emily McKloud, Eleanor M. Townsend, Leighann Sherry, Christopher Delaney, Brian L. Jones, Craig Williams, Gordon Ramage

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)


Candida auris has emerged as a significant clinical entity as it can cause outbreaks within the healthcare setting. A key feature of its nosocomial properties is that it can transfer between patients, yet little is known about the mechanisms behind this. A panel of C. auris clinical isolates were screened for their planktonic and sessile susceptibilities to skin disinfection challenge using povidone iodine, chlorhexidine and hydrogen peroxide. C. auris biofilms displayed increased tolerance to these strategies compared with planktonic cells. Additionally, analysis using a complex biofilm model demonstrated reduced susceptibility against clinically-relevant concentrations of chlorhexidine and hydrogen peroxide, with eradication achieved only using povidone iodine. Principal component analysis (PCA) also revealed distinct clustering of C. auris biofilms compared with C. albicans and C. glabrata biofilms, and directionality with respect to different treatments. These findings indicate differential responses of different Candida species with respect to antiseptic challenge against biofilms, with C. auris appearing to be more resilient as a complex community.
Original languageEnglish
Pages (from-to)673-677
Number of pages5
JournalInternational Journal of Antimicrobial Agents
Issue number5
Early online date8 Oct 2018
Publication statusPublished - Nov 2018


  • Candida auris
  • biofilms
  • antiseptics


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