@inbook{4a58b3e0ab1b4791afc5955317f7faf7,
title = "The biophysical role in tear regulation",
abstract = "The mechanism that determines and regulates tear production in the human eye has not been established. One suggested mechanism involves mediation through changes in the physical parameters of tears. Von Bahr1 was the first to propose that tear osmolality was a function of tear production and elimination. This view was elaborated by Mishima2 who suggested that the regulation of tear production was controlled by changes in tear tonicity, increases in tear tonicity leading to an increase in tear production in the normal eye, to protect the cornea from harmful changes in osmotic balance.3,4 In the instance in which low tear evaporation or an impaired drainage system occurred, this would lead to the accumulation of tears in the eye, low tonicity, and the consequent inhibition of tear production. Conversely, if high evaporation occurred in the presence of a patent drainage system this would lead to reduced tear volume, an increase in tonicity, and a stimulus to production.",
author = "Alan Tomlinson and Craig, {Jennifer P.} and Lowther, {Gerald E.}",
year = "1998",
doi = "10.1007/978-1-4615-5359-5_52",
language = "English",
isbn = "9780306458125",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer Nature",
pages = "371--380",
editor = "Sullivan, {David A.} and Dartt, {Darlene A.} and Meneray, {Michele A.}",
booktitle = "Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2: Basic Science and Clinical Relevance",
address = "United States",
}