The associations of sedentary time and breaks in sedentary time with 24-hour glycaemic control in type 2 diabetes

Aye C Paing, Kathryn A McMillan, Alison F Kirk, Andrew Collier, Allan Hewitt, Sebastien F M Chastin

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Abstract

The aim of this study was to investigate the associations of accelerometer-assessed sedentary time and breaks in sedentary time with 24-h events and duration of hypoglycaemia (7.8¿mmol/l) and above target glucose (>9¿mmol/l). Thirty-seven participants with type 2 diabetes (age, 62.8¿±¿10.5¿years; body mass index, 29.6¿±¿6.8¿kg/m(2)) in Glasgow, United Kingdom were enrolled between February 2016 and February 2017. Participants wore an activity monitor (activPAL3) recording the time and pattern of sedentary behaviour and a continuous glucose monitoring (CGM, Abbott FreeStyle Libre) for up to 14¿days. Linear regression analyses were used to investigate the associations. Participants spent 3.7%, 64.7%, 32.1% and 19.2% of recording h/day in hypoglycaemia, euglycaemia, hyperglycaemia and above target, respectively. There was a negative association between sedentary time and time in euglycaemia (ß¿=¿-0.44, 95% CI -0.86; -0.03, p¿=¿0.04). There was a trend towards a positive association between sedentary time and time in hyperglycaemia (ß¿=¿0.36, 95% CI -0.05; 0.78, p¿=¿0.08). Breaks in sedentary time was associated with higher time in euglycaemia (ß¿=¿0.38, 95% CI 0.00; 0.75, p¿=¿0.04). To conclude, in individuals with type 2 diabetes, more time spent in unbroken and continuous sedentary behaviour was associated with poorer glucose control. Conversely, interrupting sedentary time with frequent breaks appears to improve glycaemic control. Therefore, this should be considered as a simple adjunct therapy to improve clinical outcomes in type 2 diabetes.
Original languageEnglish
Pages (from-to)94-100
Number of pages7
JournalPreventive Medicine Reports
Volume12
Early online date5 Sep 2018
DOIs
Publication statusPublished - Dec 2018

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Type 2 Diabetes Mellitus
Hypoglycemia
Glucose
Hyperglycemia
Linear Models
Body Mass Index
Regression Analysis

Keywords

  • sedentary behavior
  • type 2 diabetes
  • glycaemic control

Cite this

Paing, Aye C ; McMillan, Kathryn A ; Kirk, Alison F ; Collier, Andrew ; Hewitt, Allan ; Chastin, Sebastien F M. / The associations of sedentary time and breaks in sedentary time with 24-hour glycaemic control in type 2 diabetes. In: Preventive Medicine Reports. 2018 ; Vol. 12. pp. 94-100.
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abstract = "The aim of this study was to investigate the associations of accelerometer-assessed sedentary time and breaks in sedentary time with 24-h events and duration of hypoglycaemia (7.8¿mmol/l) and above target glucose (>9¿mmol/l). Thirty-seven participants with type 2 diabetes (age, 62.8¿±¿10.5¿years; body mass index, 29.6¿±¿6.8¿kg/m(2)) in Glasgow, United Kingdom were enrolled between February 2016 and February 2017. Participants wore an activity monitor (activPAL3) recording the time and pattern of sedentary behaviour and a continuous glucose monitoring (CGM, Abbott FreeStyle Libre) for up to 14¿days. Linear regression analyses were used to investigate the associations. Participants spent 3.7{\%}, 64.7{\%}, 32.1{\%} and 19.2{\%} of recording h/day in hypoglycaemia, euglycaemia, hyperglycaemia and above target, respectively. There was a negative association between sedentary time and time in euglycaemia ({\ss}¿=¿-0.44, 95{\%} CI -0.86; -0.03, p¿=¿0.04). There was a trend towards a positive association between sedentary time and time in hyperglycaemia ({\ss}¿=¿0.36, 95{\%} CI -0.05; 0.78, p¿=¿0.08). Breaks in sedentary time was associated with higher time in euglycaemia ({\ss}¿=¿0.38, 95{\%} CI 0.00; 0.75, p¿=¿0.04). To conclude, in individuals with type 2 diabetes, more time spent in unbroken and continuous sedentary behaviour was associated with poorer glucose control. Conversely, interrupting sedentary time with frequent breaks appears to improve glycaemic control. Therefore, this should be considered as a simple adjunct therapy to improve clinical outcomes in type 2 diabetes.",
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The associations of sedentary time and breaks in sedentary time with 24-hour glycaemic control in type 2 diabetes. / Paing, Aye C; McMillan, Kathryn A; Kirk, Alison F; Collier, Andrew; Hewitt, Allan; Chastin, Sebastien F M.

In: Preventive Medicine Reports, Vol. 12, 12.2018, p. 94-100.

Research output: Contribution to journalArticle

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AU - McMillan, Kathryn A

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AB - The aim of this study was to investigate the associations of accelerometer-assessed sedentary time and breaks in sedentary time with 24-h events and duration of hypoglycaemia (7.8¿mmol/l) and above target glucose (>9¿mmol/l). Thirty-seven participants with type 2 diabetes (age, 62.8¿±¿10.5¿years; body mass index, 29.6¿±¿6.8¿kg/m(2)) in Glasgow, United Kingdom were enrolled between February 2016 and February 2017. Participants wore an activity monitor (activPAL3) recording the time and pattern of sedentary behaviour and a continuous glucose monitoring (CGM, Abbott FreeStyle Libre) for up to 14¿days. Linear regression analyses were used to investigate the associations. Participants spent 3.7%, 64.7%, 32.1% and 19.2% of recording h/day in hypoglycaemia, euglycaemia, hyperglycaemia and above target, respectively. There was a negative association between sedentary time and time in euglycaemia (ß¿=¿-0.44, 95% CI -0.86; -0.03, p¿=¿0.04). There was a trend towards a positive association between sedentary time and time in hyperglycaemia (ß¿=¿0.36, 95% CI -0.05; 0.78, p¿=¿0.08). Breaks in sedentary time was associated with higher time in euglycaemia (ß¿=¿0.38, 95% CI 0.00; 0.75, p¿=¿0.04). To conclude, in individuals with type 2 diabetes, more time spent in unbroken and continuous sedentary behaviour was associated with poorer glucose control. Conversely, interrupting sedentary time with frequent breaks appears to improve glycaemic control. Therefore, this should be considered as a simple adjunct therapy to improve clinical outcomes in type 2 diabetes.

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