The associations of sedentary time and breaks in sedentary time with 24-hour glycaemic control in type 2 diabetes

Aye C Paing; Kathryn A McMillan; Alison F Kirk; Andrew Collier; Allan Hewitt; Sebastien F M Chastin

doi:10.1016/j.pmedr.2018.09.002

The associations of sedentary time and breaks in sedentary time with 24-hour glycaemic control in type 2 diabetes

Aye C Paing, Kathryn A McMillan, Alison F Kirk, Andrew Collier, Allan Hewitt, Sebastien F M Chastin

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Abstract

The aim of this study was to investigate the associations of accelerometer-assessed sedentary time and breaks in sedentary time with 24-h events and duration of hypoglycaemia (7.8¿mmol/l) and above target glucose (>9¿mmol/l). Thirty-seven participants with type 2 diabetes (age, 62.8¿±¿10.5¿years; body mass index, 29.6¿±¿6.8¿kg/m(2)) in Glasgow, United Kingdom were enrolled between February 2016 and February 2017. Participants wore an activity monitor (activPAL3) recording the time and pattern of sedentary behaviour and a continuous glucose monitoring (CGM, Abbott FreeStyle Libre) for up to 14¿days. Linear regression analyses were used to investigate the associations. Participants spent 3.7%, 64.7%, 32.1% and 19.2% of recording h/day in hypoglycaemia, euglycaemia, hyperglycaemia and above target, respectively. There was a negative association between sedentary time and time in euglycaemia (ß¿=¿-0.44, 95% CI -0.86; -0.03, p¿=¿0.04). There was a trend towards a positive association between sedentary time and time in hyperglycaemia (ß¿=¿0.36, 95% CI -0.05; 0.78, p¿=¿0.08). Breaks in sedentary time was associated with higher time in euglycaemia (ß¿=¿0.38, 95% CI 0.00; 0.75, p¿=¿0.04). To conclude, in individuals with type 2 diabetes, more time spent in unbroken and continuous sedentary behaviour was associated with poorer glucose control. Conversely, interrupting sedentary time with frequent breaks appears to improve glycaemic control. Therefore, this should be considered as a simple adjunct therapy to improve clinical outcomes in type 2 diabetes.

Original language	English
Pages (from-to)	94-100
Number of pages	7
Journal	Preventive Medicine Reports
Volume	12
Early online date	5 Sep 2018
DOIs	https://doi.org/10.1016/j.pmedr.2018.09.002
Publication status	Published - Dec 2018

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Type 2 Diabetes Mellitus

Hypoglycemia

Glucose

Hyperglycemia

Linear Models

Body Mass Index

Regression Analysis

Keywords

sedentary behavior
type 2 diabetes
glycaemic control

Cite this

Paing, A. C., McMillan, K. A., Kirk, A. F., Collier, A., Hewitt, A., & Chastin, S. F. M. (2018). The associations of sedentary time and breaks in sedentary time with 24-hour glycaemic control in type 2 diabetes. Preventive Medicine Reports, 12, 94-100. https://doi.org/10.1016/j.pmedr.2018.09.002

Paing, Aye C ; McMillan, Kathryn A ; Kirk, Alison F ; Collier, Andrew ; Hewitt, Allan ; Chastin, Sebastien F M. / The associations of sedentary time and breaks in sedentary time with 24-hour glycaemic control in type 2 diabetes. In: Preventive Medicine Reports. 2018 ; Vol. 12. pp. 94-100.

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title = "The associations of sedentary time and breaks in sedentary time with 24-hour glycaemic control in type 2 diabetes",

abstract = "The aim of this study was to investigate the associations of accelerometer-assessed sedentary time and breaks in sedentary time with 24-h events and duration of hypoglycaemia (7.8¿mmol/l) and above target glucose (>9¿mmol/l). Thirty-seven participants with type 2 diabetes (age, 62.8¿±¿10.5¿years; body mass index, 29.6¿±¿6.8¿kg/m(2)) in Glasgow, United Kingdom were enrolled between February 2016 and February 2017. Participants wore an activity monitor (activPAL3) recording the time and pattern of sedentary behaviour and a continuous glucose monitoring (CGM, Abbott FreeStyle Libre) for up to 14¿days. Linear regression analyses were used to investigate the associations. Participants spent 3.7{\%}, 64.7{\%}, 32.1{\%} and 19.2{\%} of recording h/day in hypoglycaemia, euglycaemia, hyperglycaemia and above target, respectively. There was a negative association between sedentary time and time in euglycaemia ({\ss}¿=¿-0.44, 95{\%} CI -0.86; -0.03, p¿=¿0.04). There was a trend towards a positive association between sedentary time and time in hyperglycaemia ({\ss}¿=¿0.36, 95{\%} CI -0.05; 0.78, p¿=¿0.08). Breaks in sedentary time was associated with higher time in euglycaemia ({\ss}¿=¿0.38, 95{\%} CI 0.00; 0.75, p¿=¿0.04). To conclude, in individuals with type 2 diabetes, more time spent in unbroken and continuous sedentary behaviour was associated with poorer glucose control. Conversely, interrupting sedentary time with frequent breaks appears to improve glycaemic control. Therefore, this should be considered as a simple adjunct therapy to improve clinical outcomes in type 2 diabetes.",

keywords = "sedentary behavior , type 2 diabetes, glycaemic control",

author = "Paing, {Aye C} and McMillan, {Kathryn A} and Kirk, {Alison F} and Andrew Collier and Allan Hewitt and Chastin, {Sebastien F M}",

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doi = "10.1016/j.pmedr.2018.09.002",

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Paing, AC, McMillan, KA, Kirk, AF, Collier, A, Hewitt, A & Chastin, SFM 2018, 'The associations of sedentary time and breaks in sedentary time with 24-hour glycaemic control in type 2 diabetes', Preventive Medicine Reports, vol. 12, pp. 94-100. https://doi.org/10.1016/j.pmedr.2018.09.002

The associations of sedentary time and breaks in sedentary time with 24-hour glycaemic control in type 2 diabetes. / Paing, Aye C; McMillan, Kathryn A; Kirk, Alison F; Collier, Andrew; Hewitt, Allan; Chastin, Sebastien F M.

In: Preventive Medicine Reports, Vol. 12, 12.2018, p. 94-100.

Research output: Contribution to journal › Article

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T1 - The associations of sedentary time and breaks in sedentary time with 24-hour glycaemic control in type 2 diabetes

AU - Paing, Aye C

AU - McMillan, Kathryn A

AU - Kirk, Alison F

AU - Collier, Andrew

AU - Hewitt, Allan

AU - Chastin, Sebastien F M

N1 - Acceptance from webpage OA article, no relevant funding note

PY - 2018/12

Y1 - 2018/12

N2 - The aim of this study was to investigate the associations of accelerometer-assessed sedentary time and breaks in sedentary time with 24-h events and duration of hypoglycaemia (7.8¿mmol/l) and above target glucose (>9¿mmol/l). Thirty-seven participants with type 2 diabetes (age, 62.8¿±¿10.5¿years; body mass index, 29.6¿±¿6.8¿kg/m(2)) in Glasgow, United Kingdom were enrolled between February 2016 and February 2017. Participants wore an activity monitor (activPAL3) recording the time and pattern of sedentary behaviour and a continuous glucose monitoring (CGM, Abbott FreeStyle Libre) for up to 14¿days. Linear regression analyses were used to investigate the associations. Participants spent 3.7%, 64.7%, 32.1% and 19.2% of recording h/day in hypoglycaemia, euglycaemia, hyperglycaemia and above target, respectively. There was a negative association between sedentary time and time in euglycaemia (ß¿=¿-0.44, 95% CI -0.86; -0.03, p¿=¿0.04). There was a trend towards a positive association between sedentary time and time in hyperglycaemia (ß¿=¿0.36, 95% CI -0.05; 0.78, p¿=¿0.08). Breaks in sedentary time was associated with higher time in euglycaemia (ß¿=¿0.38, 95% CI 0.00; 0.75, p¿=¿0.04). To conclude, in individuals with type 2 diabetes, more time spent in unbroken and continuous sedentary behaviour was associated with poorer glucose control. Conversely, interrupting sedentary time with frequent breaks appears to improve glycaemic control. Therefore, this should be considered as a simple adjunct therapy to improve clinical outcomes in type 2 diabetes.

AB - The aim of this study was to investigate the associations of accelerometer-assessed sedentary time and breaks in sedentary time with 24-h events and duration of hypoglycaemia (7.8¿mmol/l) and above target glucose (>9¿mmol/l). Thirty-seven participants with type 2 diabetes (age, 62.8¿±¿10.5¿years; body mass index, 29.6¿±¿6.8¿kg/m(2)) in Glasgow, United Kingdom were enrolled between February 2016 and February 2017. Participants wore an activity monitor (activPAL3) recording the time and pattern of sedentary behaviour and a continuous glucose monitoring (CGM, Abbott FreeStyle Libre) for up to 14¿days. Linear regression analyses were used to investigate the associations. Participants spent 3.7%, 64.7%, 32.1% and 19.2% of recording h/day in hypoglycaemia, euglycaemia, hyperglycaemia and above target, respectively. There was a negative association between sedentary time and time in euglycaemia (ß¿=¿-0.44, 95% CI -0.86; -0.03, p¿=¿0.04). There was a trend towards a positive association between sedentary time and time in hyperglycaemia (ß¿=¿0.36, 95% CI -0.05; 0.78, p¿=¿0.08). Breaks in sedentary time was associated with higher time in euglycaemia (ß¿=¿0.38, 95% CI 0.00; 0.75, p¿=¿0.04). To conclude, in individuals with type 2 diabetes, more time spent in unbroken and continuous sedentary behaviour was associated with poorer glucose control. Conversely, interrupting sedentary time with frequent breaks appears to improve glycaemic control. Therefore, this should be considered as a simple adjunct therapy to improve clinical outcomes in type 2 diabetes.

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KW - type 2 diabetes

KW - glycaemic control

U2 - 10.1016/j.pmedr.2018.09.002

DO - 10.1016/j.pmedr.2018.09.002

M3 - Article

VL - 12

SP - 94

EP - 100

JO - Preventive Medicine Reports

JF - Preventive Medicine Reports

SN - 2211-3355

ER -

Paing AC, McMillan KA, Kirk AF, Collier A, Hewitt A, Chastin SFM. The associations of sedentary time and breaks in sedentary time with 24-hour glycaemic control in type 2 diabetes. Preventive Medicine Reports. 2018 Dec;12:94-100. https://doi.org/10.1016/j.pmedr.2018.09.002

Documents and Links

10.1016/j.pmedr.2018.09.002

Paing, A. C. et al (2018) The associations of sedentary time and breaks in sedentary time with 24- hour glycaemic control in type 2 diabetes
© 2018 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/)
Final published version, 739 KBLicence: CC BY-NC-ND