TY - JOUR
T1 - The associations of sedentary time and breaks in sedentary time with 24-hour glycaemic control in type 2 diabetes
AU - Paing, Aye C
AU - McMillan, Kathryn A
AU - Kirk, Alison F
AU - Collier, Andrew
AU - Hewitt, Allan
AU - Chastin, Sebastien F M
N1 - Acceptance from webpage
OA article, no relevant funding note
PY - 2018/12
Y1 - 2018/12
N2 - The aim of this study was to investigate the associations of accelerometer-assessed sedentary time and breaks in sedentary time with 24-h events and duration of hypoglycaemia (7.8¿mmol/l) and above target glucose (>9¿mmol/l). Thirty-seven participants with type 2 diabetes (age, 62.8¿±¿10.5¿years; body mass index, 29.6¿±¿6.8¿kg/m(2)) in Glasgow, United Kingdom were enrolled between February 2016 and February 2017. Participants wore an activity monitor (activPAL3) recording the time and pattern of sedentary behaviour and a continuous glucose monitoring (CGM, Abbott FreeStyle Libre) for up to 14¿days. Linear regression analyses were used to investigate the associations. Participants spent 3.7%, 64.7%, 32.1% and 19.2% of recording h/day in hypoglycaemia, euglycaemia, hyperglycaemia and above target, respectively. There was a negative association between sedentary time and time in euglycaemia (ß¿=¿-0.44, 95% CI -0.86; -0.03, p¿=¿0.04). There was a trend towards a positive association between sedentary time and time in hyperglycaemia (ß¿=¿0.36, 95% CI -0.05; 0.78, p¿=¿0.08). Breaks in sedentary time was associated with higher time in euglycaemia (ß¿=¿0.38, 95% CI 0.00; 0.75, p¿=¿0.04). To conclude, in individuals with type 2 diabetes, more time spent in unbroken and continuous sedentary behaviour was associated with poorer glucose control. Conversely, interrupting sedentary time with frequent breaks appears to improve glycaemic control. Therefore, this should be considered as a simple adjunct therapy to improve clinical outcomes in type 2 diabetes.
AB - The aim of this study was to investigate the associations of accelerometer-assessed sedentary time and breaks in sedentary time with 24-h events and duration of hypoglycaemia (7.8¿mmol/l) and above target glucose (>9¿mmol/l). Thirty-seven participants with type 2 diabetes (age, 62.8¿±¿10.5¿years; body mass index, 29.6¿±¿6.8¿kg/m(2)) in Glasgow, United Kingdom were enrolled between February 2016 and February 2017. Participants wore an activity monitor (activPAL3) recording the time and pattern of sedentary behaviour and a continuous glucose monitoring (CGM, Abbott FreeStyle Libre) for up to 14¿days. Linear regression analyses were used to investigate the associations. Participants spent 3.7%, 64.7%, 32.1% and 19.2% of recording h/day in hypoglycaemia, euglycaemia, hyperglycaemia and above target, respectively. There was a negative association between sedentary time and time in euglycaemia (ß¿=¿-0.44, 95% CI -0.86; -0.03, p¿=¿0.04). There was a trend towards a positive association between sedentary time and time in hyperglycaemia (ß¿=¿0.36, 95% CI -0.05; 0.78, p¿=¿0.08). Breaks in sedentary time was associated with higher time in euglycaemia (ß¿=¿0.38, 95% CI 0.00; 0.75, p¿=¿0.04). To conclude, in individuals with type 2 diabetes, more time spent in unbroken and continuous sedentary behaviour was associated with poorer glucose control. Conversely, interrupting sedentary time with frequent breaks appears to improve glycaemic control. Therefore, this should be considered as a simple adjunct therapy to improve clinical outcomes in type 2 diabetes.
KW - sedentary behavior
KW - type 2 diabetes
KW - glycaemic control
U2 - 10.1016/j.pmedr.2018.09.002
DO - 10.1016/j.pmedr.2018.09.002
M3 - Article
VL - 12
SP - 94
EP - 100
JO - Preventive Medicine Reports
JF - Preventive Medicine Reports
SN - 2211-3355
ER -