Temporal relationships between circulating levels of CC and CXC chemokines and developing atherosclerosis in apolipoprotein E*3 Leiden mice

Nuala Murphy, K. Richard Bruckdorfer, David .. Grimsditch, Philip Overend, Martin Vidgeon-Hart, Pieter H.E. Groot, G. Martin Benson, Annette Graham

Research output: Contribution to journalArticle

Abstract

CC and CXC chemokines are implicated in leukocyte recruitment during development of atherosclerotic lesions, suggesting circulating levels of chemokines may be useful serum markers of atherogenesis. Serum chemokine concentrations were measured in apolipoprotein (apo) E*3 Leiden mice and their nontransgenic littermates and related to the differing rates of atherogenesis in these animals. Mice were fed a high-fat, high-cholesterol/cholate (HFC/C) diet for 18 weeks. Circulating levels of JE/monocyte chemotactic protein-1 increased (P

Original languageEnglish
JournalArteriosclerosis, Thrombosis and Vascular Biology
DOIs
Publication statusPublished - 1 Jul 2003

Keywords

  • mice
  • chemokine
  • JE
  • atherosclerosis
  • KC

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