Temporal relationships between circulating levels of CC and CXC chemokines and developing atherosclerosis in apolipoprotein E*3 Leiden mice

Nuala Murphy; K. Richard Bruckdorfer; David .. Grimsditch; Philip Overend; Martin Vidgeon-Hart; Pieter H.E. Groot; G. Martin Benson; Annette Graham

doi:10.1161/01.ATV.0000084636.01328.C7

Temporal relationships between circulating levels of CC and CXC chemokines and developing atherosclerosis in apolipoprotein E*3 Leiden mice

Nuala Murphy, K. Richard Bruckdorfer, David .. Grimsditch, Philip Overend, Martin Vidgeon-Hart, Pieter H.E. Groot, G. Martin Benson, Annette Graham

Biological and Biomedical Sciences

Research output: Contribution to journal › Article

Abstract

CC and CXC chemokines are implicated in leukocyte recruitment during development of atherosclerotic lesions, suggesting circulating levels of chemokines may be useful serum markers of atherogenesis. Serum chemokine concentrations were measured in apolipoprotein (apo) E*3 Leiden mice and their nontransgenic littermates and related to the differing rates of atherogenesis in these animals. Mice were fed a high-fat, high-cholesterol/cholate (HFC/C) diet for 18 weeks. Circulating levels of JE/monocyte chemotactic protein-1 increased (P

Original language	English
Journal	Arteriosclerosis, Thrombosis and Vascular Biology
DOIs	https://doi.org/10.1161/01.ATV.0000084636.01328.C7
Publication status	Published - 1 Jul 2003

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Keywords

mice
chemokine
JE
atherosclerosis
KC

Cite this

Murphy, N., Bruckdorfer, K. R., Grimsditch, D. ., Overend, P., Vidgeon-Hart, M., Groot, P. H. E., Benson, G. M., & Graham, A. (2003). Temporal relationships between circulating levels of CC and CXC chemokines and developing atherosclerosis in apolipoprotein E*3 Leiden mice. Arteriosclerosis, Thrombosis and Vascular Biology. https://doi.org/10.1161/01.ATV.0000084636.01328.C7

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title = "Temporal relationships between circulating levels of CC and CXC chemokines and developing atherosclerosis in apolipoprotein E*3 Leiden mice",

abstract = "CC and CXC chemokines are implicated in leukocyte recruitment during development of atherosclerotic lesions, suggesting circulating levels of chemokines may be useful serum markers of atherogenesis. Serum chemokine concentrations were measured in apolipoprotein (apo) E*3 Leiden mice and their nontransgenic littermates and related to the differing rates of atherogenesis in these animals. Mice were fed a high-fat, high-cholesterol/cholate (HFC/C) diet for 18 weeks. Circulating levels of JE/monocyte chemotactic protein-1 increased (P",

keywords = "mice, chemokine, JE, atherosclerosis, KC",

author = "Nuala Murphy and Bruckdorfer, {K. Richard} and Grimsditch, {David ..} and Philip Overend and Martin Vidgeon-Hart and Groot, {Pieter H.E.} and Benson, {G. Martin} and Annette Graham",

note = "Originally published in: Arteriosclerosis, Thrombosis and Vascular Biology (2003), 23 (9), pp.1615-1620.",

year = "2003",

month = jul,

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doi = "10.1161/01.ATV.0000084636.01328.C7",

language = "English",

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Temporal relationships between circulating levels of CC and CXC chemokines and developing atherosclerosis in apolipoprotein E*3 Leiden mice. / Murphy, Nuala; Bruckdorfer, K. Richard; Grimsditch, David ..; Overend, Philip; Vidgeon-Hart, Martin; Groot, Pieter H.E.; Benson, G. Martin; Graham, Annette.

In: Arteriosclerosis, Thrombosis and Vascular Biology, 01.07.2003.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Temporal relationships between circulating levels of CC and CXC chemokines and developing atherosclerosis in apolipoprotein E*3 Leiden mice

AU - Murphy, Nuala

AU - Bruckdorfer, K. Richard

AU - Grimsditch, David ..

AU - Overend, Philip

AU - Vidgeon-Hart, Martin

AU - Groot, Pieter H.E.

AU - Benson, G. Martin

AU - Graham, Annette

N1 - Originally published in: Arteriosclerosis, Thrombosis and Vascular Biology (2003), 23 (9), pp.1615-1620.

PY - 2003/7/1

Y1 - 2003/7/1

N2 - CC and CXC chemokines are implicated in leukocyte recruitment during development of atherosclerotic lesions, suggesting circulating levels of chemokines may be useful serum markers of atherogenesis. Serum chemokine concentrations were measured in apolipoprotein (apo) E*3 Leiden mice and their nontransgenic littermates and related to the differing rates of atherogenesis in these animals. Mice were fed a high-fat, high-cholesterol/cholate (HFC/C) diet for 18 weeks. Circulating levels of JE/monocyte chemotactic protein-1 increased (P

AB - CC and CXC chemokines are implicated in leukocyte recruitment during development of atherosclerotic lesions, suggesting circulating levels of chemokines may be useful serum markers of atherogenesis. Serum chemokine concentrations were measured in apolipoprotein (apo) E*3 Leiden mice and their nontransgenic littermates and related to the differing rates of atherogenesis in these animals. Mice were fed a high-fat, high-cholesterol/cholate (HFC/C) diet for 18 weeks. Circulating levels of JE/monocyte chemotactic protein-1 increased (P

KW - mice

KW - chemokine

KW - JE

KW - atherosclerosis

KW - KC

U2 - 10.1161/01.ATV.0000084636.01328.C7

DO - 10.1161/01.ATV.0000084636.01328.C7

M3 - Article

JO - Arteriosclerosis, Thrombosis and Vascular Biology

JF - Arteriosclerosis, Thrombosis and Vascular Biology

SN - 1079-5642

ER -

Documents and Links

10.1161/01.ATV.0000084636.01328.C7

http://researchonline.gcu.ac.uk/sls/50