Abstract
CC and CXC chemokines are implicated in leukocyte recruitment during development of atherosclerotic lesions, suggesting circulating levels of chemokines may be useful serum markers of atherogenesis. Serum chemokine concentrations were measured in apolipoprotein (apo) E*3 Leiden mice and their nontransgenic littermates and related to the differing rates of atherogenesis in these animals. Mice were fed a high-fat, high-cholesterol/cholate (HFC/C) diet for 18 weeks. Circulating levels of JE/monocyte chemotactic protein-1 increased (P
Original language | English |
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Journal | Arteriosclerosis, Thrombosis and Vascular Biology |
DOIs | |
Publication status | Published - 1 Jul 2003 |
Keywords
- mice
- chemokine
- JE
- atherosclerosis
- KC