Telavancin shows superior activity to vancomycin with multidrug-resistant Staphylococcus aureus in a range of in vitro biofilm models

Karen Smith, Curtis G. Gemmell, Susan Lang

Research output: Contribution to journalArticle

Abstract

The activity of telavancin was compared with vancomycin against methicillin-resistant Staphylococcus aureus (MRSA) in planktonic culture and biofilms grown using a range of in vitro models. Antibiotic efficacy was determined using 24 clinical isolates, including healthcare-associated (HA)-MRSA, community-associated (CA)-MRSA and isolates with reduced (intermediate) susceptibility to vancomycin (VISA). Activity against biofilms was compared using three models: 96-peg plates, 96-well flat-bottom plates and a flow-cell system. Cell death was evaluated using a metabolic dye and Live/Dead staining.
Original languageEnglish
Pages (from-to)1327-1332
Number of pages6
JournalEuropean Journal of Clinical Microbiology and Infectious Diseases
Volume32
Issue number10
DOIs
Publication statusPublished - Oct 2013

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Keywords

  • telavancin
  • vancomycin
  • Staphylococcus aureus
  • biofilms

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