The activity of telavancin was compared with vancomycin against methicillin-resistant Staphylococcus aureus (MRSA) in planktonic culture and biofilms grown using a range of in vitro models. Antibiotic efficacy was determined using 24 clinical isolates, including healthcare-associated (HA)-MRSA, community-associated (CA)-MRSA and isolates with reduced (intermediate) susceptibility to vancomycin (VISA). Activity against biofilms was compared using three models: 96-peg plates, 96-well flat-bottom plates and a flow-cell system. Cell death was evaluated using a metabolic dye and Live/Dead staining.
|Number of pages||6|
|Journal||European Journal of Clinical Microbiology and Infectious Diseases|
|Publication status||Published - Oct 2013|
- Staphylococcus aureus
Smith, K., Gemmell, C. G., & Lang, S. (2013). Telavancin shows superior activity to vancomycin with multidrug-resistant Staphylococcus aureus in a range of in vitro biofilm models. European Journal of Clinical Microbiology and Infectious Diseases, 32(10), 1327-1332. https://doi.org/10.1007/s10096-013-1883-z