Telavancin shows superior activity to vancomycin with multidrug-resistant Staphylococcus aureus in a range of in vitro biofilm models

Karen Smith; Curtis G. Gemmell; Susan Lang

doi:10.1007/s10096-013-1883-z

Telavancin shows superior activity to vancomycin with multidrug-resistant Staphylococcus aureus in a range of in vitro biofilm models

Karen Smith, Curtis G. Gemmell, Susan Lang

Biological and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

The activity of telavancin was compared with vancomycin against methicillin-resistant Staphylococcus aureus (MRSA) in planktonic culture and biofilms grown using a range of in vitro models. Antibiotic efficacy was determined using 24 clinical isolates, including healthcare-associated (HA)-MRSA, community-associated (CA)-MRSA and isolates with reduced (intermediate) susceptibility to vancomycin (VISA). Activity against biofilms was compared using three models: 96-peg plates, 96-well flat-bottom plates and a flow-cell system. Cell death was evaluated using a metabolic dye and Live/Dead staining.

Original language	English
Pages (from-to)	1327-1332
Number of pages	6
Journal	European Journal of Clinical Microbiology and Infectious Diseases
Volume	32
Issue number	10
DOIs	https://doi.org/10.1007/s10096-013-1883-z
Publication status	Published - Oct 2013

Keywords

telavancin
vancomycin
Staphylococcus aureus
biofilms

Documents and Links

10.1007/s10096-013-1883-z

Cite this

@article{d8deac4ce82c490bb9fdffafda41a1c4,

title = "Telavancin shows superior activity to vancomycin with multidrug-resistant Staphylococcus aureus in a range of in vitro biofilm models",

abstract = "The activity of telavancin was compared with vancomycin against methicillin-resistant Staphylococcus aureus (MRSA) in planktonic culture and biofilms grown using a range of in vitro models. Antibiotic efficacy was determined using 24 clinical isolates, including healthcare-associated (HA)-MRSA, community-associated (CA)-MRSA and isolates with reduced (intermediate) susceptibility to vancomycin (VISA). Activity against biofilms was compared using three models: 96-peg plates, 96-well flat-bottom plates and a flow-cell system. Cell death was evaluated using a metabolic dye and Live/Dead staining.",

keywords = "telavancin, vancomycin, Staphylococcus aureus, biofilms",

author = "Karen Smith and Gemmell, {Curtis G.} and Susan Lang",

year = "2013",

month = oct,

doi = "10.1007/s10096-013-1883-z",

language = "English",

volume = "32",

pages = "1327--1332",

journal = "European Journal of Clinical Microbiology and Infectious Diseases",

issn = "0934-9723",

publisher = "Springer-Verlag",

number = "10",

}

TY - JOUR

T1 - Telavancin shows superior activity to vancomycin with multidrug-resistant Staphylococcus aureus in a range of in vitro biofilm models

AU - Smith, Karen

AU - Gemmell, Curtis G.

AU - Lang, Susan

PY - 2013/10

Y1 - 2013/10

N2 - The activity of telavancin was compared with vancomycin against methicillin-resistant Staphylococcus aureus (MRSA) in planktonic culture and biofilms grown using a range of in vitro models. Antibiotic efficacy was determined using 24 clinical isolates, including healthcare-associated (HA)-MRSA, community-associated (CA)-MRSA and isolates with reduced (intermediate) susceptibility to vancomycin (VISA). Activity against biofilms was compared using three models: 96-peg plates, 96-well flat-bottom plates and a flow-cell system. Cell death was evaluated using a metabolic dye and Live/Dead staining.

AB - The activity of telavancin was compared with vancomycin against methicillin-resistant Staphylococcus aureus (MRSA) in planktonic culture and biofilms grown using a range of in vitro models. Antibiotic efficacy was determined using 24 clinical isolates, including healthcare-associated (HA)-MRSA, community-associated (CA)-MRSA and isolates with reduced (intermediate) susceptibility to vancomycin (VISA). Activity against biofilms was compared using three models: 96-peg plates, 96-well flat-bottom plates and a flow-cell system. Cell death was evaluated using a metabolic dye and Live/Dead staining.

KW - telavancin

KW - vancomycin

KW - Staphylococcus aureus

KW - biofilms

U2 - 10.1007/s10096-013-1883-z

DO - 10.1007/s10096-013-1883-z

M3 - Article

VL - 32

SP - 1327

EP - 1332

JO - European Journal of Clinical Microbiology and Infectious Diseases

JF - European Journal of Clinical Microbiology and Infectious Diseases

SN - 0934-9723

IS - 10

ER -

Telavancin shows superior activity to vancomycin with multidrug-resistant Staphylococcus aureus in a range of in vitro biofilm models

Abstract

Keywords

Documents and Links

Fingerprint

Cite this