Telavancin shows superior activity to vancomycin with multidrug-resistant Staphylococcus aureus in a range of in vitro biofilm models

Karen Smith; Curtis G. Gemmell; Susan Lang

doi:10.1007/s10096-013-1883-z

Telavancin shows superior activity to vancomycin with multidrug-resistant Staphylococcus aureus in a range of in vitro biofilm models

Karen Smith, Curtis G. Gemmell, Susan Lang

Biological and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The activity of telavancin was compared with vancomycin against methicillin-resistant Staphylococcus aureus (MRSA) in planktonic culture and biofilms grown using a range of in vitro models. Antibiotic efficacy was determined using 24 clinical isolates, including healthcare-associated (HA)-MRSA, community-associated (CA)-MRSA and isolates with reduced (intermediate) susceptibility to vancomycin (VISA). Activity against biofilms was compared using three models: 96-peg plates, 96-well flat-bottom plates and a flow-cell system. Cell death was evaluated using a metabolic dye and Live/Dead staining.

Original language	English
Pages (from-to)	1327-1332
Number of pages	6
Journal	European Journal of Clinical Microbiology and Infectious Diseases
Volume	32
Issue number	10
DOIs	https://doi.org/10.1007/s10096-013-1883-z
Publication status	Published - Oct 2013

Keywords

telavancin
vancomycin
Staphylococcus aureus
biofilms

Documents and Links

10.1007/s10096-013-1883-z

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title = "Telavancin shows superior activity to vancomycin with multidrug-resistant Staphylococcus aureus in a range of in vitro biofilm models",

abstract = "The activity of telavancin was compared with vancomycin against methicillin-resistant Staphylococcus aureus (MRSA) in planktonic culture and biofilms grown using a range of in vitro models. Antibiotic efficacy was determined using 24 clinical isolates, including healthcare-associated (HA)-MRSA, community-associated (CA)-MRSA and isolates with reduced (intermediate) susceptibility to vancomycin (VISA). Activity against biofilms was compared using three models: 96-peg plates, 96-well flat-bottom plates and a flow-cell system. Cell death was evaluated using a metabolic dye and Live/Dead staining.",

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AU - Smith, Karen

AU - Gemmell, Curtis G.

AU - Lang, Susan

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AB - The activity of telavancin was compared with vancomycin against methicillin-resistant Staphylococcus aureus (MRSA) in planktonic culture and biofilms grown using a range of in vitro models. Antibiotic efficacy was determined using 24 clinical isolates, including healthcare-associated (HA)-MRSA, community-associated (CA)-MRSA and isolates with reduced (intermediate) susceptibility to vancomycin (VISA). Activity against biofilms was compared using three models: 96-peg plates, 96-well flat-bottom plates and a flow-cell system. Cell death was evaluated using a metabolic dye and Live/Dead staining.

KW - telavancin

KW - vancomycin

KW - Staphylococcus aureus

KW - biofilms

U2 - 10.1007/s10096-013-1883-z

DO - 10.1007/s10096-013-1883-z

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JO - European Journal of Clinical Microbiology and Infectious Diseases

JF - European Journal of Clinical Microbiology and Infectious Diseases

SN - 0934-9723

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ER -