Abstract
The activity of telavancin was compared with vancomycin against methicillin-resistant Staphylococcus aureus (MRSA) in planktonic culture and biofilms grown using a range of in vitro models. Antibiotic efficacy was determined using 24 clinical isolates, including healthcare-associated (HA)-MRSA, community-associated (CA)-MRSA and isolates with reduced (intermediate) susceptibility to vancomycin (VISA). Activity against biofilms was compared using three models: 96-peg plates, 96-well flat-bottom plates and a flow-cell system. Cell death was evaluated using a metabolic dye and Live/Dead staining.
Original language | English |
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Pages (from-to) | 1327-1332 |
Number of pages | 6 |
Journal | European Journal of Clinical Microbiology and Infectious Diseases |
Volume | 32 |
Issue number | 10 |
DOIs | |
Publication status | Published - Oct 2013 |
Keywords
- telavancin
- vancomycin
- Staphylococcus aureus
- biofilms