Tear physiology of aqueous deficiency and evaporative dry eye

Khanal Santosh; Alan Tomlinson; Charles J.M. Diaper

doi:10.1097/OPX.0b013e3181bc63cc

Tear physiology of aqueous deficiency and evaporative dry eye

Khanal Santosh, Alan Tomlinson, Charles J.M. Diaper

Vision Sciences

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

This study aimed to determine the differences in tear physiology between aqueous deficiency dry eye (ADDE) and evaporative dry eye (EDE), and evaluate their utility in diagnosis. Fifty-six dry eye patients were classified into 30 ADDE and 26 EDE according to the recently published Dry Eye Workshop criteria. A range of tear physiology measures comprising of tear evaporation, turnover rate (TTR), distribution, volume and osmolarity, and meibomian gland dropout were measured in these patients. The effectiveness of the tests, singly and in combinations, in differentiating between the dry eye subtypes was evaluated by retrospective allocation into groups and by Receiver Operative Characteristics (ROC) curve analysis.

Original language	English
Pages (from-to)	1235-1240
Number of pages	6
Journal	Optometry and Vision Science
Volume	86
Issue number	11
DOIs	https://doi.org/10.1097/OPX.0b013e3181bc63cc
Publication status	Published - 1 Nov 2009

Keywords

cornea
tear physiology
vision sciences

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10.1097/OPX.0b013e3181bc63cc

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title = "Tear physiology of aqueous deficiency and evaporative dry eye",

abstract = "This study aimed to determine the differences in tear physiology between aqueous deficiency dry eye (ADDE) and evaporative dry eye (EDE), and evaluate their utility in diagnosis. Fifty-six dry eye patients were classified into 30 ADDE and 26 EDE according to the recently published Dry Eye Workshop criteria. A range of tear physiology measures comprising of tear evaporation, turnover rate (TTR), distribution, volume and osmolarity, and meibomian gland dropout were measured in these patients. The effectiveness of the tests, singly and in combinations, in differentiating between the dry eye subtypes was evaluated by retrospective allocation into groups and by Receiver Operative Characteristics (ROC) curve analysis.",

keywords = "cornea, tear physiology, vision sciences",

author = "Khanal Santosh and Alan Tomlinson and Diaper, {Charles J.M.}",

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AU - Santosh, Khanal

AU - Tomlinson, Alan

AU - Diaper, Charles J.M.

N1 - <p>Originally published in: Optometry and Vision Science (2009), 86 (11), pp.1235-1240.</p>

PY - 2009/11/1

Y1 - 2009/11/1

N2 - This study aimed to determine the differences in tear physiology between aqueous deficiency dry eye (ADDE) and evaporative dry eye (EDE), and evaluate their utility in diagnosis. Fifty-six dry eye patients were classified into 30 ADDE and 26 EDE according to the recently published Dry Eye Workshop criteria. A range of tear physiology measures comprising of tear evaporation, turnover rate (TTR), distribution, volume and osmolarity, and meibomian gland dropout were measured in these patients. The effectiveness of the tests, singly and in combinations, in differentiating between the dry eye subtypes was evaluated by retrospective allocation into groups and by Receiver Operative Characteristics (ROC) curve analysis.

AB - This study aimed to determine the differences in tear physiology between aqueous deficiency dry eye (ADDE) and evaporative dry eye (EDE), and evaluate their utility in diagnosis. Fifty-six dry eye patients were classified into 30 ADDE and 26 EDE according to the recently published Dry Eye Workshop criteria. A range of tear physiology measures comprising of tear evaporation, turnover rate (TTR), distribution, volume and osmolarity, and meibomian gland dropout were measured in these patients. The effectiveness of the tests, singly and in combinations, in differentiating between the dry eye subtypes was evaluated by retrospective allocation into groups and by Receiver Operative Characteristics (ROC) curve analysis.

KW - cornea

KW - tear physiology

KW - vision sciences

U2 - 10.1097/OPX.0b013e3181bc63cc

DO - 10.1097/OPX.0b013e3181bc63cc

M3 - Article

SN - 1538-9235

VL - 86

SP - 1235

EP - 1240

JO - Optometry and Vision Science

JF - Optometry and Vision Science

IS - 11

ER -

Tear physiology of aqueous deficiency and evaporative dry eye

Abstract

Keywords

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