Tear physiology of aqueous deficiency and evaporative dry eye

Khanal Santosh, Alan Tomlinson, Charles J.M. Diaper

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)


This study aimed to determine the differences in tear physiology between aqueous deficiency dry eye (ADDE) and evaporative dry eye (EDE), and evaluate their utility in diagnosis. Fifty-six dry eye patients were classified into 30 ADDE and 26 EDE according to the recently published Dry Eye Workshop criteria. A range of tear physiology measures comprising of tear evaporation, turnover rate (TTR), distribution, volume and osmolarity, and meibomian gland dropout were measured in these patients. The effectiveness of the tests, singly and in combinations, in differentiating between the dry eye subtypes was evaluated by retrospective allocation into groups and by Receiver Operative Characteristics (ROC) curve analysis.

Original languageEnglish
Pages (from-to)1235-1240
Number of pages6
JournalOptometry and Vision Science
Issue number11
Publication statusPublished - 1 Nov 2009


  • cornea
  • tear physiology
  • vision sciences


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