Tear film stability and tear break up time (TBUT) in laboratory rabbits - a systematic review

Michael J. Doughty

Research output: Contribution to journalArticle

Abstract

Several older studies on rabbits indicated that the pre-corneal tear film was unusually stable and this perspective was revisited recently. However, the methods used for these studies were very different from those generally used in human studies. A literature search was undertaken for the time period of 1965 through 2017, mainly using PubMed, to identify studies where values for the tear break up time (TBUT) were reported for the eyes of nominally normal (healthy) laboratory rabbits regardless of breed or age and where the methods were more similar to those routinely used in human clinical studies. For 20 reports identified where sodium fluorescein was used, the average TBUT values in any particular study ranged from 1.9 to 51 s, with a group mean of 21.8 ± 11.9 s (SD), with the inter-study variability in TBUT (as the coefficient of variation) being 19.4%. For four studies not using fluorescein, the mean break up time reported was 32.7 ± 16.2 s, while a separate study (also not using fluorescein) reported an average break up time of 1788 s. Most reports of the pre-corneal tear film stability in laboratory rabbits, especially as reported over the last 10 years, indicate break up times of less than 60 s have been observed, although has been little consistency in the methods used. Overall, this outcome is not consistent with a perspective that the rabbit (as routinely used in experimental studies) has an extraordinarily stable tear film.
Original languageEnglish
Pages (from-to)961-964
Number of pages4
JournalCurrent Eye Research
Volume43
Issue number8
Early online date9 Apr 2018
DOIs
Publication statusPublished - 2018

Fingerprint

Tears
Rabbits
Fluorescein
PubMed

Keywords

  • rabbit, tear break up time, tear breakup time, TBUT, tear film, tear stability

Cite this

@article{de799ff5425d4937be1f40c56a9fe83e,
title = "Tear film stability and tear break up time (TBUT) in laboratory rabbits - a systematic review",
abstract = "Several older studies on rabbits indicated that the pre-corneal tear film was unusually stable and this perspective was revisited recently. However, the methods used for these studies were very different from those generally used in human studies. A literature search was undertaken for the time period of 1965 through 2017, mainly using PubMed, to identify studies where values for the tear break up time (TBUT) were reported for the eyes of nominally normal (healthy) laboratory rabbits regardless of breed or age and where the methods were more similar to those routinely used in human clinical studies. For 20 reports identified where sodium fluorescein was used, the average TBUT values in any particular study ranged from 1.9 to 51 s, with a group mean of 21.8 ± 11.9 s (SD), with the inter-study variability in TBUT (as the coefficient of variation) being 19.4{\%}. For four studies not using fluorescein, the mean break up time reported was 32.7 ± 16.2 s, while a separate study (also not using fluorescein) reported an average break up time of 1788 s. Most reports of the pre-corneal tear film stability in laboratory rabbits, especially as reported over the last 10 years, indicate break up times of less than 60 s have been observed, although has been little consistency in the methods used. Overall, this outcome is not consistent with a perspective that the rabbit (as routinely used in experimental studies) has an extraordinarily stable tear film.",
keywords = "rabbit, tear break up time, tear breakup time, TBUT, tear film, tear stability",
author = "Doughty, {Michael J.}",
note = "AAM requested 250718 DC and 21-8-18 ET Acceptance from webpage Not exception result added by library as no response from author and has left GCU. ET 17/10/18",
year = "2018",
doi = "10.1080/02713683.2018.1457164",
language = "English",
volume = "43",
pages = "961--964",
journal = "Current Eye Research",
issn = "0271-3683",
publisher = "Taylor and Francis Ltd.",
number = "8",

}

Tear film stability and tear break up time (TBUT) in laboratory rabbits - a systematic review. / Doughty, Michael J.

In: Current Eye Research, Vol. 43, No. 8, 2018, p. 961-964.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Tear film stability and tear break up time (TBUT) in laboratory rabbits - a systematic review

AU - Doughty, Michael J.

N1 - AAM requested 250718 DC and 21-8-18 ET Acceptance from webpage Not exception result added by library as no response from author and has left GCU. ET 17/10/18

PY - 2018

Y1 - 2018

N2 - Several older studies on rabbits indicated that the pre-corneal tear film was unusually stable and this perspective was revisited recently. However, the methods used for these studies were very different from those generally used in human studies. A literature search was undertaken for the time period of 1965 through 2017, mainly using PubMed, to identify studies where values for the tear break up time (TBUT) were reported for the eyes of nominally normal (healthy) laboratory rabbits regardless of breed or age and where the methods were more similar to those routinely used in human clinical studies. For 20 reports identified where sodium fluorescein was used, the average TBUT values in any particular study ranged from 1.9 to 51 s, with a group mean of 21.8 ± 11.9 s (SD), with the inter-study variability in TBUT (as the coefficient of variation) being 19.4%. For four studies not using fluorescein, the mean break up time reported was 32.7 ± 16.2 s, while a separate study (also not using fluorescein) reported an average break up time of 1788 s. Most reports of the pre-corneal tear film stability in laboratory rabbits, especially as reported over the last 10 years, indicate break up times of less than 60 s have been observed, although has been little consistency in the methods used. Overall, this outcome is not consistent with a perspective that the rabbit (as routinely used in experimental studies) has an extraordinarily stable tear film.

AB - Several older studies on rabbits indicated that the pre-corneal tear film was unusually stable and this perspective was revisited recently. However, the methods used for these studies were very different from those generally used in human studies. A literature search was undertaken for the time period of 1965 through 2017, mainly using PubMed, to identify studies where values for the tear break up time (TBUT) were reported for the eyes of nominally normal (healthy) laboratory rabbits regardless of breed or age and where the methods were more similar to those routinely used in human clinical studies. For 20 reports identified where sodium fluorescein was used, the average TBUT values in any particular study ranged from 1.9 to 51 s, with a group mean of 21.8 ± 11.9 s (SD), with the inter-study variability in TBUT (as the coefficient of variation) being 19.4%. For four studies not using fluorescein, the mean break up time reported was 32.7 ± 16.2 s, while a separate study (also not using fluorescein) reported an average break up time of 1788 s. Most reports of the pre-corneal tear film stability in laboratory rabbits, especially as reported over the last 10 years, indicate break up times of less than 60 s have been observed, although has been little consistency in the methods used. Overall, this outcome is not consistent with a perspective that the rabbit (as routinely used in experimental studies) has an extraordinarily stable tear film.

KW - rabbit, tear break up time, tear breakup time, TBUT, tear film, tear stability

U2 - 10.1080/02713683.2018.1457164

DO - 10.1080/02713683.2018.1457164

M3 - Article

VL - 43

SP - 961

EP - 964

JO - Current Eye Research

JF - Current Eye Research

SN - 0271-3683

IS - 8

ER -