Tear film osmolarity: determination of a referent for dry eye diagnosis

Alan Tomlinson; Santosh Khanal; Kanna Ramaesh; Charles J.M. Diaper; Angus K. McFadyen

doi:10.1167/iovs.05-1504

Tear film osmolarity: determination of a referent for dry eye diagnosis

Alan Tomlinson, Santosh Khanal, Kanna Ramaesh, Charles J.M. Diaper, Angus K. McFadyen

Vision Sciences

Research output: Contribution to journal › Article › peer-review

471 Citations (Scopus)

Abstract

The purpose of this study was to determine new referents, or cutoff levels for tear film hyperosmolarity in the diagnosis of keratoconjunctivitis sicca (KCS) and to assess their effectiveness in independent patient groups. Tear hyperosmolarity, defined by a referent of 316 mOsmol/L, was superior in overall accuracy to any other single test for dry eye diagnosis (Lactoplate, Schirmer test, and Rose Bengal staining), even when the other test measures were applied to a diagnosis within the sample groups from which they were derived. For overall accuracy in the diagnosis of dry eye, the osmolarity test was found to be comparable with the results of combined (in parallel or series) tests.

Original language	English
Journal	Investigative Ophthalmology & Visual Science
DOIs	https://doi.org/10.1167/iovs.05-1504
Publication status	Published - 1 Oct 2006

Keywords

dry eye
vision sciences
keratoconjunctivitis sicca
osmolarity

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10.1167/iovs.05-1504

Cite this

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title = "Tear film osmolarity: determination of a referent for dry eye diagnosis",

abstract = "The purpose of this study was to determine new referents, or cutoff levels for tear film hyperosmolarity in the diagnosis of keratoconjunctivitis sicca (KCS) and to assess their effectiveness in independent patient groups. Tear hyperosmolarity, defined by a referent of 316 mOsmol/L, was superior in overall accuracy to any other single test for dry eye diagnosis (Lactoplate, Schirmer test, and Rose Bengal staining), even when the other test measures were applied to a diagnosis within the sample groups from which they were derived. For overall accuracy in the diagnosis of dry eye, the osmolarity test was found to be comparable with the results of combined (in parallel or series) tests.",

keywords = "dry eye, vision sciences, keratoconjunctivitis sicca, osmolarity",

author = "Alan Tomlinson and Santosh Khanal and Kanna Ramaesh and Diaper, {Charles J.M.} and McFadyen, {Angus K.}",

note = "Originally published in: Investigative Ophthalmology & Visual Science (2006), 47 (10), pp.4309-4315.",

year = "2006",

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doi = "10.1167/iovs.05-1504",

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journal = "Investigative Ophthalmology & Visual Science",

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T1 - Tear film osmolarity: determination of a referent for dry eye diagnosis

AU - Tomlinson, Alan

AU - Khanal, Santosh

AU - Ramaesh, Kanna

AU - Diaper, Charles J.M.

AU - McFadyen, Angus K.

N1 - Originally published in: Investigative Ophthalmology & Visual Science (2006), 47 (10), pp.4309-4315.

PY - 2006/10/1

Y1 - 2006/10/1

N2 - The purpose of this study was to determine new referents, or cutoff levels for tear film hyperosmolarity in the diagnosis of keratoconjunctivitis sicca (KCS) and to assess their effectiveness in independent patient groups. Tear hyperosmolarity, defined by a referent of 316 mOsmol/L, was superior in overall accuracy to any other single test for dry eye diagnosis (Lactoplate, Schirmer test, and Rose Bengal staining), even when the other test measures were applied to a diagnosis within the sample groups from which they were derived. For overall accuracy in the diagnosis of dry eye, the osmolarity test was found to be comparable with the results of combined (in parallel or series) tests.

AB - The purpose of this study was to determine new referents, or cutoff levels for tear film hyperosmolarity in the diagnosis of keratoconjunctivitis sicca (KCS) and to assess their effectiveness in independent patient groups. Tear hyperosmolarity, defined by a referent of 316 mOsmol/L, was superior in overall accuracy to any other single test for dry eye diagnosis (Lactoplate, Schirmer test, and Rose Bengal staining), even when the other test measures were applied to a diagnosis within the sample groups from which they were derived. For overall accuracy in the diagnosis of dry eye, the osmolarity test was found to be comparable with the results of combined (in parallel or series) tests.

KW - dry eye

KW - vision sciences

KW - keratoconjunctivitis sicca

KW - osmolarity

U2 - 10.1167/iovs.05-1504

DO - 10.1167/iovs.05-1504

M3 - Article

SN - 1552-5783

JO - Investigative Ophthalmology & Visual Science

JF - Investigative Ophthalmology & Visual Science

ER -

Tear film osmolarity: determination of a referent for dry eye diagnosis

Abstract

Keywords

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