Abstract
A focused library of novel 2,3-dihydro-1H-1,5-benzodiazepin-2-ones containing sites for 11C-, 18F- and 123I-labelling have been prepared and evaluated against membrane expressing human recombinant metabotropic glutamate 2 receptor (mGluR2). The compounds were found to be non-competitive antagonists with nanomolar affinity. HPLC evaluation of the physiochemical properties of these compounds identified two candidates for PET and SPECT imaging of mGluR2.
Original language | English |
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Pages (from-to) | 1118-1123 |
Number of pages | 6 |
Journal | MedChemComm |
Volume | 4 |
Early online date | 29 May 2013 |
DOIs | |
Publication status | Published - 1 Jul 2013 |
Keywords
- organic chemistry
- medicinal chemistry
- medical imaging
ASJC Scopus subject areas
- Organic Chemistry