Surface disinfection properties of the combination of an antimicrobial peptide, ranalexin, with an endopeptidase, lysostaphin, against methicillin-resistant Staphylococcus aureus (MRSA)

A. P. Desbois, Sue Lang, Curtis G. Gemmell, P. J. Coote

Research output: Contribution to journalArticle

Abstract

The aim of this study was to characterize the antibacterial synergy of the antimicrobial peptide, ranalexin, used in combination with the anti-staphylococcal endopeptidase, lysostaphin, against methicillin-resistant Staphylococcus aureus (MRSA), and to assess the combination’s potential as a topical disinfectant or decolonizing agent for MRSA. MRSA causes potentially lethal infections, and pre-operative patients colonized with MRSA are often treated with chlorhexidine digluconate and mupirocin cream to eradicate carriage. However, chlorhexidine is unsuitable for some patients, and mupirocin resistance is increasingly encountered, indicating new agents are required.

Original languageEnglish
Pages (from-to)723-730
Number of pages8
JournalJournal of Applied Microbiology
Volume108
Issue number2
DOIs
Publication statusPublished - 1 Feb 2010

Keywords

  • MRSA
  • disinfectants
  • antimicrobial peptides

Fingerprint Dive into the research topics of 'Surface disinfection properties of the combination of an antimicrobial peptide, ranalexin, with an endopeptidase, lysostaphin, against methicillin-resistant Staphylococcus aureus (MRSA)'. Together they form a unique fingerprint.

  • Cite this