Surface disinfection properties of the combination of an antimicrobial peptide, ranalexin, with an endopeptidase, lysostaphin, against methicillin-resistant Staphylococcus aureus (MRSA)

A. P. Desbois; Sue Lang; Curtis G. Gemmell; P. J. Coote

doi:10.1111/j.1365-2672.2009.04472.x

Surface disinfection properties of the combination of an antimicrobial peptide, ranalexin, with an endopeptidase, lysostaphin, against methicillin-resistant Staphylococcus aureus (MRSA)

A. P. Desbois, Sue Lang, Curtis G. Gemmell, P. J. Coote

Biological and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

The aim of this study was to characterize the antibacterial synergy of the antimicrobial peptide, ranalexin, used in combination with the anti-staphylococcal endopeptidase, lysostaphin, against methicillin-resistant Staphylococcus aureus (MRSA), and to assess the combination’s potential as a topical disinfectant or decolonizing agent for MRSA. MRSA causes potentially lethal infections, and pre-operative patients colonized with MRSA are often treated with chlorhexidine digluconate and mupirocin cream to eradicate carriage. However, chlorhexidine is unsuitable for some patients, and mupirocin resistance is increasingly encountered, indicating new agents are required.

Original language	English
Pages (from-to)	723-730
Number of pages	8
Journal	Journal of Applied Microbiology
Volume	108
Issue number	2
DOIs	https://doi.org/10.1111/j.1365-2672.2009.04472.x
Publication status	Published - 1 Feb 2010

Keywords

MRSA
disinfectants
antimicrobial peptides

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10.1111/j.1365-2672.2009.04472.x

Cite this

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title = "Surface disinfection properties of the combination of an antimicrobial peptide, ranalexin, with an endopeptidase, lysostaphin, against methicillin-resistant Staphylococcus aureus (MRSA)",

abstract = "The aim of this study was to characterize the antibacterial synergy of the antimicrobial peptide, ranalexin, used in combination with the anti-staphylococcal endopeptidase, lysostaphin, against methicillin-resistant Staphylococcus aureus (MRSA), and to assess the combination{\textquoteright}s potential as a topical disinfectant or decolonizing agent for MRSA. MRSA causes potentially lethal infections, and pre-operative patients colonized with MRSA are often treated with chlorhexidine digluconate and mupirocin cream to eradicate carriage. However, chlorhexidine is unsuitable for some patients, and mupirocin resistance is increasingly encountered, indicating new agents are required.",

keywords = "MRSA, disinfectants, antimicrobial peptides",

author = "Desbois, {A. P.} and Sue Lang and Gemmell, {Curtis G.} and Coote, {P. J.}",

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Surface disinfection properties of the combination of an antimicrobial peptide, ranalexin, with an endopeptidase, lysostaphin, against methicillin-resistant Staphylococcus aureus (MRSA). / Desbois, A. P.; Lang, Sue; Gemmell, Curtis G. et al.
In: Journal of Applied Microbiology, Vol. 108, No. 2, 01.02.2010, p. 723-730.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Surface disinfection properties of the combination of an antimicrobial peptide, ranalexin, with an endopeptidase, lysostaphin, against methicillin-resistant Staphylococcus aureus (MRSA)

AU - Desbois, A. P.

AU - Lang, Sue

AU - Gemmell, Curtis G.

AU - Coote, P. J.

N1 - Originally published in: Journal of Applied Microbiology (2010), 108 (2), pp.723-730.

PY - 2010/2/1

Y1 - 2010/2/1

N2 - The aim of this study was to characterize the antibacterial synergy of the antimicrobial peptide, ranalexin, used in combination with the anti-staphylococcal endopeptidase, lysostaphin, against methicillin-resistant Staphylococcus aureus (MRSA), and to assess the combination’s potential as a topical disinfectant or decolonizing agent for MRSA. MRSA causes potentially lethal infections, and pre-operative patients colonized with MRSA are often treated with chlorhexidine digluconate and mupirocin cream to eradicate carriage. However, chlorhexidine is unsuitable for some patients, and mupirocin resistance is increasingly encountered, indicating new agents are required.

AB - The aim of this study was to characterize the antibacterial synergy of the antimicrobial peptide, ranalexin, used in combination with the anti-staphylococcal endopeptidase, lysostaphin, against methicillin-resistant Staphylococcus aureus (MRSA), and to assess the combination’s potential as a topical disinfectant or decolonizing agent for MRSA. MRSA causes potentially lethal infections, and pre-operative patients colonized with MRSA are often treated with chlorhexidine digluconate and mupirocin cream to eradicate carriage. However, chlorhexidine is unsuitable for some patients, and mupirocin resistance is increasingly encountered, indicating new agents are required.

KW - MRSA

KW - disinfectants

KW - antimicrobial peptides

U2 - 10.1111/j.1365-2672.2009.04472.x

DO - 10.1111/j.1365-2672.2009.04472.x

M3 - Article

SN - 1365-2672

VL - 108

SP - 723

EP - 730

JO - Journal of Applied Microbiology

JF - Journal of Applied Microbiology

IS - 2

ER -

Surface disinfection properties of the combination of an antimicrobial peptide, ranalexin, with an endopeptidase, lysostaphin, against methicillin-resistant Staphylococcus aureus (MRSA)

Abstract

Keywords

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