Suggestions for the diagnosis and elimination of hepatitis E virus in pigs used for xenotransplantation

Stacey Busby; Claire Crossan; Jon Godwin; Bjoern Petersen; Cesare Galli; Emanuele Cozzi; Yasuhiro Takeuchi; Linda Scobie

doi:10.1111/xen.12038

Suggestions for the diagnosis and elimination of hepatitis E virus in pigs used for xenotransplantation

Stacey Busby, Claire Crossan, Jon Godwin, Bjoern Petersen, Cesare Galli, Emanuele Cozzi, Yasuhiro Takeuchi, Linda Scobie

Research output: Contribution to journal › Article › peer-review

Abstract

The hepatitis E virus (HEV) is considered a zoonotic pathogen. In xenotransplantation, given the high prevalence of HEV infection in pigs, the risk of zoonotic transmission from a porcine source is considered high. Currently no clear data are available on how to diagnose and eliminate HEV in herds used for medical purposes and the importance of viral infection at the stage of harvest. In this study, several groups of animals currently used for medical purposes were found RNA positive in both serum and faeces for HEV genotype 3.

Original language	English
Pages (from-to)	188–192
Number of pages	5
Journal	Xenotransplantation
Volume	20
Issue number	3
Early online date	7 May 2013
DOIs	https://doi.org/10.1111/xen.12038
Publication status	Published - Jun 2013

Keywords

hepatitis E virus
xenotransplantation
porcine cell biology
viral infection

Documents and Links

10.1111/xen.12038

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title = "Suggestions for the diagnosis and elimination of hepatitis E virus in pigs used for xenotransplantation",

abstract = "The hepatitis E virus (HEV) is considered a zoonotic pathogen. In xenotransplantation, given the high prevalence of HEV infection in pigs, the risk of zoonotic transmission from a porcine source is considered high. Currently no clear data are available on how to diagnose and eliminate HEV in herds used for medical purposes and the importance of viral infection at the stage of harvest. In this study, several groups of animals currently used for medical purposes were found RNA positive in both serum and faeces for HEV genotype 3.",

keywords = "hepatitis E virus, xenotransplantation, porcine cell biology, viral infection",

author = "Stacey Busby and Claire Crossan and Jon Godwin and Bjoern Petersen and Cesare Galli and Emanuele Cozzi and Yasuhiro Takeuchi and Linda Scobie",

year = "2013",

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T1 - Suggestions for the diagnosis and elimination of hepatitis E virus in pigs used for xenotransplantation

AU - Busby, Stacey

AU - Crossan, Claire

AU - Godwin, Jon

AU - Petersen, Bjoern

AU - Galli, Cesare

AU - Cozzi, Emanuele

AU - Takeuchi, Yasuhiro

AU - Scobie, Linda

PY - 2013/6

Y1 - 2013/6

N2 - The hepatitis E virus (HEV) is considered a zoonotic pathogen. In xenotransplantation, given the high prevalence of HEV infection in pigs, the risk of zoonotic transmission from a porcine source is considered high. Currently no clear data are available on how to diagnose and eliminate HEV in herds used for medical purposes and the importance of viral infection at the stage of harvest. In this study, several groups of animals currently used for medical purposes were found RNA positive in both serum and faeces for HEV genotype 3.

AB - The hepatitis E virus (HEV) is considered a zoonotic pathogen. In xenotransplantation, given the high prevalence of HEV infection in pigs, the risk of zoonotic transmission from a porcine source is considered high. Currently no clear data are available on how to diagnose and eliminate HEV in herds used for medical purposes and the importance of viral infection at the stage of harvest. In this study, several groups of animals currently used for medical purposes were found RNA positive in both serum and faeces for HEV genotype 3.

KW - hepatitis E virus

KW - xenotransplantation

KW - porcine cell biology

KW - viral infection

U2 - 10.1111/xen.12038

DO - 10.1111/xen.12038

M3 - Article

VL - 20

SP - 188

EP - 192

JO - Xenotransplantation

JF - Xenotransplantation

SN - 0908-665X

IS - 3

ER -