Stroke outcomes in clinical trials patients deriving from different countries

Myzoon Ali; Sari  Atula; Philip M.W.  Bath; James  Grotta,; Werner Hacke; Patrick  Lyden; John  Marler; Ralph   Sacco; Kennedy R. Lees

doi:10.1161/STROKEAHA.108.518035

Stroke outcomes in clinical trials patients deriving from different countries

Myzoon Ali, Sari Atula, Philip M.W. Bath, James Grotta,, Werner Hacke, Patrick Lyden, John Marler, Ralph Sacco, Kennedy R. Lees

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Abstract

Stroke incidence and outcome vary widely within and across geographical locations. We examined whether differences in index stroke severity, stroke risk factors, mortality, and stroke outcome across geographical locations remain after adjusting for case mix. We analyzed 3284 patients from the Virtual International Stroke Trials Archive (VISTA). We used logistic regression to examine the incidence of mild index stroke, functional, and neurological outcomes after accounting for age, medical history, year of trial recruitment, and initial stroke severity in the functional and neurological outcome analyses. We examined mortality between geographical regions using a Cox proportional hazards model, accounting for age, initial stroke severity, medical history, and year of trial recruitment.

Original language	English
Pages (from-to)	35-40
Number of pages	6
Journal	Stroke
Volume	40
Issue number	1
Early online date	16 Sep 2008
DOIs	https://doi.org/10.1161/STROKEAHA.108.518035
Publication status	Published - 2009

Keywords

acute care
clinical trials
stroke
epidemiology

Documents and Links

10.1161/STROKEAHA.108.518035

Ali, M. el al (2009) Stroke outcomes in clinical trials patients deriving from different countries
This is the accepted author manuscript of the article in Stroke published by the American Heart Association. Available at: http://stroke.ahajournals.org/content/40/1/35 © 2008 American Heart Association, Inc.
Accepted author manuscript, 321 KB

http://stroke.ahajournals.org/content/40/1/35.abstract

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Ali, M., Atula, S., Bath, P. M. W., Grotta, J., Hacke, W., Lyden, P., Marler, J., Sacco, R., & Lees, K. R. (2009). Stroke outcomes in clinical trials patients deriving from different countries. Stroke, 40(1), 35-40. https://doi.org/10.1161/STROKEAHA.108.518035

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AU - Atula, Sari

AU - Bath, Philip M.W.

AU - Grotta,, James

AU - Hacke, Werner

AU - Lyden, Patrick

AU - Marler, John

AU - Sacco, Ralph

AU - Lees, Kennedy R.

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AB - Stroke incidence and outcome vary widely within and across geographical locations. We examined whether differences in index stroke severity, stroke risk factors, mortality, and stroke outcome across geographical locations remain after adjusting for case mix. We analyzed 3284 patients from the Virtual International Stroke Trials Archive (VISTA). We used logistic regression to examine the incidence of mild index stroke, functional, and neurological outcomes after accounting for age, medical history, year of trial recruitment, and initial stroke severity in the functional and neurological outcome analyses. We examined mortality between geographical regions using a Cox proportional hazards model, accounting for age, initial stroke severity, medical history, and year of trial recruitment.

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