Stroke outcomes in clinical trials patients deriving from different countries

Myzoon Ali, Sari Atula, Philip M.W. Bath, James Grotta,, Werner Hacke, Patrick Lyden, John Marler, Ralph Sacco, Kennedy R. Lees

    Research output: Contribution to journalArticle

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    Abstract

    Stroke incidence and outcome vary widely within and across geographical locations. We examined whether differences in index stroke severity, stroke risk factors, mortality, and stroke outcome across geographical locations remain after adjusting for case mix. We analyzed 3284 patients from the Virtual International Stroke Trials Archive (VISTA). We used logistic regression to examine the incidence of mild index stroke, functional, and neurological outcomes after accounting for age, medical history, year of trial recruitment, and initial stroke severity in the functional and neurological outcome analyses. We examined mortality between geographical regions using a Cox proportional hazards model, accounting for age, initial stroke severity, medical history, and year of trial recruitment.
    Original languageEnglish
    Pages (from-to)35-40
    Number of pages6
    JournalStroke
    Volume40
    Issue number1
    Early online date16 Sep 2008
    DOIs
    Publication statusPublished - 2009

    Fingerprint

    Stroke
    Clinical Trials
    Mortality
    Diagnosis-Related Groups
    Incidence
    Proportional Hazards Models
    Logistic Models

    Keywords

    • acute care
    • clinical trials
    • stroke
    • epidemiology

    Cite this

    Ali, M., Atula, S., Bath, P. M. W., Grotta, J., Hacke, W., Lyden, P., ... Lees, K. R. (2009). Stroke outcomes in clinical trials patients deriving from different countries. Stroke, 40(1), 35-40. https://doi.org/10.1161/STROKEAHA.108.518035
    Ali, Myzoon ; Atula, Sari ; Bath, Philip M.W. ; Grotta, James ; Hacke, Werner ; Lyden, Patrick ; Marler, John ; Sacco, Ralph ; Lees, Kennedy R. / Stroke outcomes in clinical trials patients deriving from different countries. In: Stroke. 2009 ; Vol. 40, No. 1. pp. 35-40.
    @article{0529688072f24cca88247b451325876a,
    title = "Stroke outcomes in clinical trials patients deriving from different countries",
    abstract = "Stroke incidence and outcome vary widely within and across geographical locations. We examined whether differences in index stroke severity, stroke risk factors, mortality, and stroke outcome across geographical locations remain after adjusting for case mix. We analyzed 3284 patients from the Virtual International Stroke Trials Archive (VISTA). We used logistic regression to examine the incidence of mild index stroke, functional, and neurological outcomes after accounting for age, medical history, year of trial recruitment, and initial stroke severity in the functional and neurological outcome analyses. We examined mortality between geographical regions using a Cox proportional hazards model, accounting for age, initial stroke severity, medical history, and year of trial recruitment.",
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    author = "Myzoon Ali and Sari Atula and Bath, {Philip M.W.} and James Grotta, and Werner Hacke and Patrick Lyden and John Marler and Ralph Sacco and Lees, {Kennedy R.}",
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    Ali, M, Atula, S, Bath, PMW, Grotta, J, Hacke, W, Lyden, P, Marler, J, Sacco, R & Lees, KR 2009, 'Stroke outcomes in clinical trials patients deriving from different countries', Stroke, vol. 40, no. 1, pp. 35-40. https://doi.org/10.1161/STROKEAHA.108.518035

    Stroke outcomes in clinical trials patients deriving from different countries. / Ali, Myzoon; Atula, Sari ; Bath, Philip M.W.; Grotta, James ; Hacke, Werner; Lyden, Patrick ; Marler, John ; Sacco, Ralph ; Lees, Kennedy R.

    In: Stroke, Vol. 40, No. 1, 2009, p. 35-40.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Stroke outcomes in clinical trials patients deriving from different countries

    AU - Ali, Myzoon

    AU - Atula, Sari

    AU - Bath, Philip M.W.

    AU - Grotta,, James

    AU - Hacke, Werner

    AU - Lyden, Patrick

    AU - Marler, John

    AU - Sacco, Ralph

    AU - Lees, Kennedy R.

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    AB - Stroke incidence and outcome vary widely within and across geographical locations. We examined whether differences in index stroke severity, stroke risk factors, mortality, and stroke outcome across geographical locations remain after adjusting for case mix. We analyzed 3284 patients from the Virtual International Stroke Trials Archive (VISTA). We used logistic regression to examine the incidence of mild index stroke, functional, and neurological outcomes after accounting for age, medical history, year of trial recruitment, and initial stroke severity in the functional and neurological outcome analyses. We examined mortality between geographical regions using a Cox proportional hazards model, accounting for age, initial stroke severity, medical history, and year of trial recruitment.

    KW - acute care

    KW - clinical trials

    KW - stroke

    KW - epidemiology

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    SP - 35

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    JO - Stroke

    JF - Stroke

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    IS - 1

    ER -