Stroke outcomes in clinical trials patients deriving from different countries

Myzoon Ali, Sari Atula, Philip M.W. Bath, James Grotta,, Werner Hacke, Patrick Lyden, John Marler, Ralph Sacco, Kennedy R. Lees

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    Abstract

    Stroke incidence and outcome vary widely within and across geographical locations. We examined whether differences in index stroke severity, stroke risk factors, mortality, and stroke outcome across geographical locations remain after adjusting for case mix. We analyzed 3284 patients from the Virtual International Stroke Trials Archive (VISTA). We used logistic regression to examine the incidence of mild index stroke, functional, and neurological outcomes after accounting for age, medical history, year of trial recruitment, and initial stroke severity in the functional and neurological outcome analyses. We examined mortality between geographical regions using a Cox proportional hazards model, accounting for age, initial stroke severity, medical history, and year of trial recruitment.
    Original languageEnglish
    Pages (from-to)35-40
    Number of pages6
    JournalStroke
    Volume40
    Issue number1
    Early online date16 Sep 2008
    DOIs
    Publication statusPublished - 2009

    Keywords

    • acute care
    • clinical trials
    • stroke
    • epidemiology

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  • Cite this

    Ali, M., Atula, S., Bath, P. M. W., Grotta, J., Hacke, W., Lyden, P., Marler, J., Sacco, R., & Lees, K. R. (2009). Stroke outcomes in clinical trials patients deriving from different countries. Stroke, 40(1), 35-40. https://doi.org/10.1161/STROKEAHA.108.518035