Strategies to enhance the safety profile of xenotransplantation: minimizing the risk of viral zoonoses

Giada Mattiuzzo; Linda Scobie; Yasuhiro Takeuchi

doi:10.1097/MOT.0b013e3282f7961e

Strategies to enhance the safety profile of xenotransplantation: minimizing the risk of viral zoonoses

Giada Mattiuzzo, Linda Scobie, Yasuhiro Takeuchi

Biological and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Pig-to-human xenotransplantation has taken steps closer to reality through advances in animal engineering to address immunological as well as microbial problems. The most highlighted problem in xenotransplantation safety has been the potential risk for zoonotic infection mediated by porcine endogenous retroviruses. Safety issues regarding viral zoonosis, particularly porcine endogenous retroviruses, are summarized and commented upon.

Original language	English
Pages (from-to)	184-188
Number of pages	5
Journal	Current Opinion in Organ Transplantation
Volume	13
Issue number	2
DOIs	https://doi.org/10.1097/MOT.0b013e3282f7961e
Publication status	Published - 1 Apr 2008

Keywords

retrovirus infection
cell transplantation
pigs

Documents and Links

10.1097/MOT.0b013e3282f7961e

http://researchonline.gcu.ac.uk/sls/301

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Cite this

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title = "Strategies to enhance the safety profile of xenotransplantation: minimizing the risk of viral zoonoses",

abstract = "Pig-to-human xenotransplantation has taken steps closer to reality through advances in animal engineering to address immunological as well as microbial problems. The most highlighted problem in xenotransplantation safety has been the potential risk for zoonotic infection mediated by porcine endogenous retroviruses. Safety issues regarding viral zoonosis, particularly porcine endogenous retroviruses, are summarized and commented upon.",

keywords = "retrovirus infection, cell transplantation, pigs",

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AB - Pig-to-human xenotransplantation has taken steps closer to reality through advances in animal engineering to address immunological as well as microbial problems. The most highlighted problem in xenotransplantation safety has been the potential risk for zoonotic infection mediated by porcine endogenous retroviruses. Safety issues regarding viral zoonosis, particularly porcine endogenous retroviruses, are summarized and commented upon.

KW - retrovirus infection

KW - cell transplantation

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