Simultaneous detection of sulfamethoxazole, diclofenac, carbamazepine, and bezafibrate by solid phase extraction and high performance liquid chromatography with diode array detection

Zhengwei Zhou, Jia-Qian Jiang

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

A method of solid phase extraction (SPE) coupled with high performance liquid chromatography and diode array detection (HPLC-DAD) was studied for the simultaneous determination of sulfamethoxazole (SMX), diclofenac (DCF), carbamazepine (CBZ), and bezafi brate (BZF) in test solutions. The target compounds were extracted by SPE from samples, and the resulting elutes were analyzed using a HPLC-DAD system at wavelengths of 270, 280, 290, and 230 nm for SMX, DCF, CBZ, and BZF, respectively. This method shows good recoveries for SMX, DCF, CBZ, and BZF with mean recoveries of 89.7 ± 9.3%, 86.1 ± 7.6%, 95.0 ± 6.5%, and 94.0 ± 5.4%, respectively.
Original languageEnglish
Pages (from-to)273-278
Number of pages6
JournalJournal of Applied Spectroscopy
Volume81
Issue number2
DOIs
Publication statusPublished - May 2014

Keywords

  • spectroscopy
  • solid phase extraction
  • chromatography

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