Short-term incubation of equine laminar veins with cortisol and insulin alters contractility in vitro: possible implications for the pathogenesis of equine laminitis

John A. Keen, Bruce C. McGorum, Chris Hillier, Jane Nally

Research output: Contribution to journalArticle

Abstract

This study investigated the effects of cortisol and insulin, hormones that affect
both glycaemic status and vascular function, on the in vitro contractility of
isolated healthy equine small laminar veins. Small veins (150–500 lm)
draining the digital laminae from healthy horses or ponies were investigated
by wire myography. Concentration response curves were constructed for noradrenaline (NA), phenylephrine (PE), endothelin-1 (ET-1) and 5 hydroxytryptamine (5-HT) in the presence of either cortisol (106M) or insulin (1000 lIU/mL).
Original languageEnglish
Pages (from-to)382-388
Number of pages7
JournalJournal of Veterinary Pharmacology and Therapeutics
Volume36
Issue number4
Early online date3 Sep 2012
DOIs
Publication statusPublished - Aug 2013

Keywords

  • equine laminitis
  • diabetes
  • cortisol
  • insulin resistance

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