Severe acute respiratory syndrome coronavirus 2 serosurveillance in a patient population reveals differences in virus exposure and antibody-mediated immunity according to host demography and healthcare setting

Ellen C. Hughes, Julien A. R. Amat, Joanne Haney, Yasmin A. Parr, Nicola Logan, Norah Palmateer, Sema Nickbakhsh, Antonia Ho, Peter Cherepanov, Annachiara Rosa, Andrew McAuley, Alice Broos, Imogen Herbert, Ursula Arthur, Agnieszka M. Szemiel, Chloe Roustan, Elizabeth Dickson, Rory N. Gunson, Mafalda Viana, Brian J. WillettPablo R. Murcia*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Abstract

Identifying drivers of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure and quantifying population immunity is crucial to prepare for future epidemics. We performed a serial cross-sectional serosurvey throughout the first pandemic wave among patients from the largest health board in Scotland. Screening of 7480 patient serum samples showed a weekly seroprevalence ranging from 0.10% to 8.23% in primary and 0.21% to 17.44% in secondary care, respectively. Neutralization assays showed that highly neutralizing antibodies developed in about half of individuals who tested positive with enzyme-linked immunosorbent assay, mainly among secondary care patients. We estimated the individual probability of SARS-CoV-2 exposure and quantified associated risk factors. We show that secondary care patients, male patients, and 45–64-year-olds exhibit a higher probability of being seropositive. The identification of risk factors and the differences in virus neutralization activity between patient populations provided insights into the patterns of virus exposure during the first pandemic wave and shed light on what to expect in future waves.
Original languageEnglish
Article numberjiaa788
Pages (from-to)971-980
Number of pages10
JournalJournal of Infectious Diseases
Volume223
Issue number6
Early online date26 Dec 2020
DOIs
Publication statusPublished - 15 Mar 2021

Keywords

  • Adolescent
  • Adult
  • Aged
  • Antibodies, Neutralizing/blood
  • Antibodies, Viral/blood
  • COVID-19/diagnosis
  • Cell Line
  • Cross-Sectional Studies
  • Delivery of Health Care
  • Demography
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Immunity
  • Male
  • Middle Aged
  • Pandemics
  • Risk Factors
  • SARS-CoV-2/immunology
  • Scotland/epidemiology
  • Seroepidemiologic Studies
  • Young Adult

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