Role of the serotonin transporter in pulmonary arterial hypertension

Yvonne Dempsie, Margaret R MacLean

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)


Pulmonary arterial hypertension is a disease in which pulmonary arterial pressure is raised, leading to right heart failure. Survival is poor despite current therapeutic strategies. The 'serotonin hypothesis of pulmonary arterial hypertension' arose in the 1960s following an 'epidemic' of pulmonary arterial hypertension in women taking the indirect serotinergic agonist aminorex as an anorexigen. In the 1980s, the hypothesis was revisited following the occurrence of pulmonary arterial hypertension associated with the use of fenfluramines as anorexigens; these are also indirect serotinergic agents. Research has identified changes in serotonin synthesis, serotonin receptor activation and serotonin uptake via the serotonin transporter in experimental and clinical pulmonary arterial hypertension. This review will discuss our current understanding of this serotonin hypothesis with particular reference to the role of the serotonin transporter.
Original languageEnglish
Pages (from-to)749-57
Number of pages9
JournalExpert Review of Clinical Pharmacology
Issue number6
Publication statusPublished - Nov 2008


  • serotonin transporter
  • pulmonary arterial hypertension
  • agonist


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