Role of microRNA in muscle regeneration and diseases related to muscle dysfunction in atrophy, cachexia, osteoporosis, and osteoarthritis

Joanna Brzeszczyńska*, Filip Brzeszczyński, David F. Hamilton, Robin McGregor, A.Hamish R.W. Simpson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)
1 Downloads (Pure)

Abstract

MicroRNAs (miRNAs) are a class of small non-coding RNAs that have emerged as potential predictive, prognostic, and therapeutic biomarkers, relevant to many pathophysiological conditions including limb immobilization, osteoarthritis, sarcopenia, and cachexia. Impaired musculoskeletal homeostasis leads to distinct muscle atrophies. Understanding miRNA involvement in the molecular mechanisms underpinning conditions such as muscle wasting may be critical to developing new strategies to improve patient management. MicroRNAs are powerful post-transcriptional regulators of gene expression in muscle and, importantly, are also detectable in the circulation. MicroRNAs are established modulators of muscle satellite stem cell activation, proliferation, and differentiation, however, there have been limited human studies that investigate miRNAs in muscle wasting. This narrative review summarizes the current knowledge as to the role of miRNAs in the skeletal muscle differentiation and atrophy, synthesizing the findings of published data.

Original languageEnglish
Pages (from-to)798-807
Number of pages10
JournalBone and Joint Research
Volume9
Issue number11
Early online date11 Nov 2020
DOIs
Publication statusPublished - Nov 2020

Keywords

  • miRNA
  • muscle
  • atrophy
  • regeneration

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

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