RELEASE: a protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia

Marian C. Brady, Myzoon Ali, Kathryn VandenBerg, Linda J. Williams, Louise R. Williams, Masahiro Abo, Frank Becker, Audrey Bowen, Caitlin Brandenburg, Caterina Breitenstein, Steffanie Bruehl, David A. Copeland, Tamara B. Cranfill, Marie di Pietro-Bachmann, Pamela Enderby, Joanne Fillingham, Federica Lucia Galli, Marialuisa Gandolfi, Bertrand Glize, Erin GodeckeNeil Hawkins, Katerina Hilari, Jacqueline Hinckley, Simon Horton, David Howard, Petra Jaecks, Elizabeth Jefferies, Luis M.T. Jesus, Maria Kambanaros, Eun Kyoung Kang, Eman M. Khedr, Anthony Pak-Hin Kong, Tarja Kukkonen, Marina Laganaro, Matthew A. Lambon Ralph, Ann Charlotte Laska, Beatrice Leemann, Alexander P. Leff, Roxele R. Lima, Antje Lorenz, Brian MacWhinney, Rebecca Shisler Marshall, Flavia Mattioli, Ilknur Mavis, Marcus Meinzer, Reza Nilipour, Enrique Noe, Nam-Jong Paik, Rebecca Palmer, Ilias Papathanasiou , Brigida F. Patricio, Isabel Pavão Martins, Cathy Price, Tatjana Prizl Jakovac , Elizabeth Rochon , Miranda L. Rose, Charlotte Rosso, Ilona Rubi-Fessen , Marina B. Ruiter , Claerwen Snell , Benjamin Stahl , Jerzy P. Szaflarski , Shirley A. Thomas , Meike van de Sandt-Koenderman, Ineke van der Meulen, Evy Visch-Brink, Linda Worrall, Heather Harris Wright

Research output: Contribution to journalArticle

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Abstract

Background: Speech and language therapy (SLT) benefits people with aphasia following stroke. Group level summary statistics from randomised controlled trials hinder exploration of highly complex SLT interventions and a clinically relevant heterogeneous population. Creating a database of individual participant data (IPD) for people with aphasia aims to allow exploration of individual and therapy-related predictors of recovery and prognosis.

Aim: To explore the contribution that individual participant characteristics (including stroke and aphasia profiles) and SLT intervention components make to language recovery following stroke.

Methods and procedures: We will identify eligible IPD datasets (including randomised controlled trials, non-randomised comparison studies, observational studies and registries) and invite their contribution to the database. Where possible, we will use meta- and network meta-analysis to explore language performance after stroke and predictors of recovery as it relates to participants who had no SLT, historical SLT or SLT in the primary research study. We will also examine the components of effective SLT interventions.

Outcomes and results: Outcomes include changes in measures of functional communication, overall severity of language impairment, auditory comprehension, spoken language (including naming), reading and writing from baseline. Data captured on assessment tools will be collated and transformed to a standardised measure for each of the outcome domains.

Conclusion: Our planned systematic-review-based IPD meta- and network meta-analysis is a large scale, international, multidisciplinary and methodologically complex endeavour. It will enable hypotheses to be generated and tested to optimise and inform development of interventions for people with aphasia after stroke.
Original languageEnglish
Number of pages23
JournalAphasiology
Early online date25 Aug 2019
DOIs
Publication statusE-pub ahead of print - 25 Aug 2019

Fingerprint

Language Therapy
Speech Therapy
Aphasia
speech disorder
stroke
Stroke
language
Language
Databases
Network Meta-Analysis
Meta-analysis
Therapy
Systematic Review
Observational Studies
Registries
Reading
Randomized Controlled Trials
Communication
spoken language
Outcome Assessment (Health Care)

Keywords

  • stroke
  • aphasia
  • complex intervention
  • IPD
  • meta-analysis

Cite this

Brady, Marian C. ; Ali, Myzoon ; VandenBerg, Kathryn ; Williams, Linda J. ; Williams, Louise R. ; Abo, Masahiro ; Becker, Frank ; Bowen, Audrey ; Brandenburg, Caitlin ; Breitenstein, Caterina ; Bruehl, Steffanie ; Copeland, David A. ; Cranfill, Tamara B. ; di Pietro-Bachmann, Marie ; Enderby, Pamela ; Fillingham, Joanne ; Galli, Federica Lucia ; Gandolfi, Marialuisa ; Glize, Bertrand ; Godecke, Erin ; Hawkins, Neil ; Hilari, Katerina ; Hinckley, Jacqueline ; Horton, Simon ; Howard, David ; Jaecks, Petra ; Jefferies, Elizabeth ; Jesus, Luis M.T. ; Kambanaros, Maria ; Kang, Eun Kyoung ; Khedr, Eman M. ; Kong, Anthony Pak-Hin ; Kukkonen, Tarja ; Laganaro, Marina ; Lambon Ralph, Matthew A. ; Laska, Ann Charlotte ; Leemann, Beatrice ; Leff, Alexander P. ; Lima, Roxele R. ; Lorenz, Antje ; MacWhinney, Brian ; Marshall, Rebecca Shisler ; Mattioli, Flavia ; Mavis, Ilknur ; Meinzer, Marcus ; Nilipour, Reza ; Noe, Enrique ; Paik, Nam-Jong ; Palmer, Rebecca ; Papathanasiou , Ilias ; Patricio, Brigida F. ; Pavão Martins, Isabel ; Price, Cathy ; Prizl Jakovac , Tatjana ; Rochon , Elizabeth ; Rose, Miranda L. ; Rosso, Charlotte ; Rubi-Fessen , Ilona ; Ruiter , Marina B. ; Snell , Claerwen ; Stahl , Benjamin ; Szaflarski , Jerzy P. ; Thomas , Shirley A. ; van de Sandt-Koenderman, Meike ; van der Meulen, Ineke ; Visch-Brink, Evy ; Worrall, Linda ; Harris Wright, Heather. / RELEASE: a protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia. In: Aphasiology. 2019.
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title = "RELEASE: a protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia",
abstract = "Background: Speech and language therapy (SLT) benefits people with aphasia following stroke. Group level summary statistics from randomised controlled trials hinder exploration of highly complex SLT interventions and a clinically relevant heterogeneous population. Creating a database of individual participant data (IPD) for people with aphasia aims to allow exploration of individual and therapy-related predictors of recovery and prognosis.Aim: To explore the contribution that individual participant characteristics (including stroke and aphasia profiles) and SLT intervention components make to language recovery following stroke.Methods and procedures: We will identify eligible IPD datasets (including randomised controlled trials, non-randomised comparison studies, observational studies and registries) and invite their contribution to the database. Where possible, we will use meta- and network meta-analysis to explore language performance after stroke and predictors of recovery as it relates to participants who had no SLT, historical SLT or SLT in the primary research study. We will also examine the components of effective SLT interventions.Outcomes and results: Outcomes include changes in measures of functional communication, overall severity of language impairment, auditory comprehension, spoken language (including naming), reading and writing from baseline. Data captured on assessment tools will be collated and transformed to a standardised measure for each of the outcome domains.Conclusion: Our planned systematic-review-based IPD meta- and network meta-analysis is a large scale, international, multidisciplinary and methodologically complex endeavour. It will enable hypotheses to be generated and tested to optimise and inform development of interventions for people with aphasia after stroke.",
keywords = "stroke, aphasia, complex intervention, IPD, meta-analysis",
author = "Brady, {Marian C.} and Myzoon Ali and Kathryn VandenBerg and Williams, {Linda J.} and Williams, {Louise R.} and Masahiro Abo and Frank Becker and Audrey Bowen and Caitlin Brandenburg and Caterina Breitenstein and Steffanie Bruehl and Copeland, {David A.} and Cranfill, {Tamara B.} and {di Pietro-Bachmann}, Marie and Pamela Enderby and Joanne Fillingham and Galli, {Federica Lucia} and Marialuisa Gandolfi and Bertrand Glize and Erin Godecke and Neil Hawkins and Katerina Hilari and Jacqueline Hinckley and Simon Horton and David Howard and Petra Jaecks and Elizabeth Jefferies and Jesus, {Luis M.T.} and Maria Kambanaros and Kang, {Eun Kyoung} and Khedr, {Eman M.} and Kong, {Anthony Pak-Hin} and Tarja Kukkonen and Marina Laganaro and {Lambon Ralph}, {Matthew A.} and Laska, {Ann Charlotte} and Beatrice Leemann and Leff, {Alexander P.} and Lima, {Roxele R.} and Antje Lorenz and Brian MacWhinney and Marshall, {Rebecca Shisler} and Flavia Mattioli and Ilknur Mavis and Marcus Meinzer and Reza Nilipour and Enrique Noe and Nam-Jong Paik and Rebecca Palmer and Ilias Papathanasiou and Patricio, {Brigida F.} and {Pav{\~a}o Martins}, Isabel and Cathy Price and {Prizl Jakovac}, Tatjana and Elizabeth Rochon and Rose, {Miranda L.} and Charlotte Rosso and Ilona Rubi-Fessen and Ruiter, {Marina B.} and Claerwen Snell and Benjamin Stahl and Szaflarski, {Jerzy P.} and Thomas, {Shirley A.} and {van de Sandt-Koenderman}, Meike and {van der Meulen}, Ineke and Evy Visch-Brink and Linda Worrall and {Harris Wright}, Heather",
note = "Acceptance from webpage OA article",
year = "2019",
month = "8",
day = "25",
doi = "10.1080/02687038.2019.1643003",
language = "English",
journal = "Aphasiology",
issn = "0268-7038",
publisher = "Taylor and Francis Ltd.",

}

Brady, MC, Ali, M, VandenBerg, K, Williams, LJ, Williams, LR, Abo, M, Becker, F, Bowen, A, Brandenburg, C, Breitenstein, C, Bruehl, S, Copeland, DA, Cranfill, TB, di Pietro-Bachmann, M, Enderby, P, Fillingham, J, Galli, FL, Gandolfi, M, Glize, B, Godecke, E, Hawkins, N, Hilari, K, Hinckley, J, Horton, S, Howard, D, Jaecks, P, Jefferies, E, Jesus, LMT, Kambanaros, M, Kang, EK, Khedr, EM, Kong, AP-H, Kukkonen, T, Laganaro, M, Lambon Ralph, MA, Laska, AC, Leemann, B, Leff, AP, Lima, RR, Lorenz, A, MacWhinney, B, Marshall, RS, Mattioli, F, Mavis, I, Meinzer, M, Nilipour, R, Noe, E, Paik, N-J, Palmer, R, Papathanasiou , I, Patricio, BF, Pavão Martins, I, Price, C, Prizl Jakovac , T, Rochon , E, Rose, ML, Rosso, C, Rubi-Fessen , I, Ruiter , MB, Snell , C, Stahl , B, Szaflarski , JP, Thomas , SA, van de Sandt-Koenderman, M, van der Meulen, I, Visch-Brink, E, Worrall, L & Harris Wright, H 2019, 'RELEASE: a protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia', Aphasiology. https://doi.org/10.1080/02687038.2019.1643003

RELEASE: a protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia. / Brady, Marian C.; Ali, Myzoon; VandenBerg, Kathryn; Williams, Linda J.; Williams, Louise R.; Abo, Masahiro ; Becker, Frank; Bowen, Audrey; Brandenburg, Caitlin ; Breitenstein, Caterina; Bruehl, Steffanie; Copeland, David A.; Cranfill, Tamara B.; di Pietro-Bachmann, Marie; Enderby, Pamela ; Fillingham, Joanne; Galli, Federica Lucia; Gandolfi, Marialuisa; Glize, Bertrand; Godecke, Erin; Hawkins, Neil; Hilari, Katerina; Hinckley, Jacqueline; Horton, Simon; Howard, David; Jaecks, Petra ; Jefferies, Elizabeth; Jesus, Luis M.T.; Kambanaros, Maria ; Kang, Eun Kyoung; Khedr, Eman M.; Kong, Anthony Pak-Hin; Kukkonen, Tarja; Laganaro, Marina; Lambon Ralph, Matthew A.; Laska, Ann Charlotte; Leemann, Beatrice; Leff, Alexander P.; Lima, Roxele R.; Lorenz, Antje; MacWhinney, Brian; Marshall, Rebecca Shisler; Mattioli, Flavia; Mavis, Ilknur; Meinzer, Marcus; Nilipour, Reza; Noe, Enrique; Paik, Nam-Jong; Palmer, Rebecca; Papathanasiou , Ilias; Patricio, Brigida F.; Pavão Martins, Isabel; Price, Cathy; Prizl Jakovac , Tatjana ; Rochon , Elizabeth; Rose, Miranda L.; Rosso, Charlotte; Rubi-Fessen , Ilona; Ruiter , Marina B.; Snell , Claerwen; Stahl , Benjamin; Szaflarski , Jerzy P.; Thomas , Shirley A.; van de Sandt-Koenderman, Meike; van der Meulen, Ineke; Visch-Brink, Evy; Worrall, Linda; Harris Wright, Heather.

In: Aphasiology, 25.08.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - RELEASE: a protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia

AU - Brady, Marian C.

AU - Ali, Myzoon

AU - VandenBerg, Kathryn

AU - Williams, Linda J.

AU - Williams, Louise R.

AU - Abo, Masahiro

AU - Becker, Frank

AU - Bowen, Audrey

AU - Brandenburg, Caitlin

AU - Breitenstein, Caterina

AU - Bruehl, Steffanie

AU - Copeland, David A.

AU - Cranfill, Tamara B.

AU - di Pietro-Bachmann, Marie

AU - Enderby, Pamela

AU - Fillingham, Joanne

AU - Galli, Federica Lucia

AU - Gandolfi, Marialuisa

AU - Glize, Bertrand

AU - Godecke, Erin

AU - Hawkins, Neil

AU - Hilari, Katerina

AU - Hinckley, Jacqueline

AU - Horton, Simon

AU - Howard, David

AU - Jaecks, Petra

AU - Jefferies, Elizabeth

AU - Jesus, Luis M.T.

AU - Kambanaros, Maria

AU - Kang, Eun Kyoung

AU - Khedr, Eman M.

AU - Kong, Anthony Pak-Hin

AU - Kukkonen, Tarja

AU - Laganaro, Marina

AU - Lambon Ralph, Matthew A.

AU - Laska, Ann Charlotte

AU - Leemann, Beatrice

AU - Leff, Alexander P.

AU - Lima, Roxele R.

AU - Lorenz, Antje

AU - MacWhinney, Brian

AU - Marshall, Rebecca Shisler

AU - Mattioli, Flavia

AU - Mavis, Ilknur

AU - Meinzer, Marcus

AU - Nilipour, Reza

AU - Noe, Enrique

AU - Paik, Nam-Jong

AU - Palmer, Rebecca

AU - Papathanasiou , Ilias

AU - Patricio, Brigida F.

AU - Pavão Martins, Isabel

AU - Price, Cathy

AU - Prizl Jakovac , Tatjana

AU - Rochon , Elizabeth

AU - Rose, Miranda L.

AU - Rosso, Charlotte

AU - Rubi-Fessen , Ilona

AU - Ruiter , Marina B.

AU - Snell , Claerwen

AU - Stahl , Benjamin

AU - Szaflarski , Jerzy P.

AU - Thomas , Shirley A.

AU - van de Sandt-Koenderman, Meike

AU - van der Meulen, Ineke

AU - Visch-Brink, Evy

AU - Worrall, Linda

AU - Harris Wright, Heather

N1 - Acceptance from webpage OA article

PY - 2019/8/25

Y1 - 2019/8/25

N2 - Background: Speech and language therapy (SLT) benefits people with aphasia following stroke. Group level summary statistics from randomised controlled trials hinder exploration of highly complex SLT interventions and a clinically relevant heterogeneous population. Creating a database of individual participant data (IPD) for people with aphasia aims to allow exploration of individual and therapy-related predictors of recovery and prognosis.Aim: To explore the contribution that individual participant characteristics (including stroke and aphasia profiles) and SLT intervention components make to language recovery following stroke.Methods and procedures: We will identify eligible IPD datasets (including randomised controlled trials, non-randomised comparison studies, observational studies and registries) and invite their contribution to the database. Where possible, we will use meta- and network meta-analysis to explore language performance after stroke and predictors of recovery as it relates to participants who had no SLT, historical SLT or SLT in the primary research study. We will also examine the components of effective SLT interventions.Outcomes and results: Outcomes include changes in measures of functional communication, overall severity of language impairment, auditory comprehension, spoken language (including naming), reading and writing from baseline. Data captured on assessment tools will be collated and transformed to a standardised measure for each of the outcome domains.Conclusion: Our planned systematic-review-based IPD meta- and network meta-analysis is a large scale, international, multidisciplinary and methodologically complex endeavour. It will enable hypotheses to be generated and tested to optimise and inform development of interventions for people with aphasia after stroke.

AB - Background: Speech and language therapy (SLT) benefits people with aphasia following stroke. Group level summary statistics from randomised controlled trials hinder exploration of highly complex SLT interventions and a clinically relevant heterogeneous population. Creating a database of individual participant data (IPD) for people with aphasia aims to allow exploration of individual and therapy-related predictors of recovery and prognosis.Aim: To explore the contribution that individual participant characteristics (including stroke and aphasia profiles) and SLT intervention components make to language recovery following stroke.Methods and procedures: We will identify eligible IPD datasets (including randomised controlled trials, non-randomised comparison studies, observational studies and registries) and invite their contribution to the database. Where possible, we will use meta- and network meta-analysis to explore language performance after stroke and predictors of recovery as it relates to participants who had no SLT, historical SLT or SLT in the primary research study. We will also examine the components of effective SLT interventions.Outcomes and results: Outcomes include changes in measures of functional communication, overall severity of language impairment, auditory comprehension, spoken language (including naming), reading and writing from baseline. Data captured on assessment tools will be collated and transformed to a standardised measure for each of the outcome domains.Conclusion: Our planned systematic-review-based IPD meta- and network meta-analysis is a large scale, international, multidisciplinary and methodologically complex endeavour. It will enable hypotheses to be generated and tested to optimise and inform development of interventions for people with aphasia after stroke.

KW - stroke

KW - aphasia

KW - complex intervention

KW - IPD

KW - meta-analysis

U2 - 10.1080/02687038.2019.1643003

DO - 10.1080/02687038.2019.1643003

M3 - Article

JO - Aphasiology

JF - Aphasiology

SN - 0268-7038

ER -