Abstract
The aim of the present study was to determine the relative contribution of prostanoids, nitric oxide and K+ channels in the bradykinin-induced relaxation of bovine pulmonary supernumerary arteries. These studies suggest that in bovine pulmonary supernumerary arteries bradykinin can stimulate the formation of nitric oxide and activate an EDHF-like mechanism and that either of these pathways alone can mediate the bradykinin-induced relaxation. In addition nitric oxide, acting through guanylyl cyclase, can activate an apamin/charbydotoxin-sensitive K+ channel in this tissue.
| Original language | English |
|---|---|
| Journal | British Journal of Pharmacology |
| Publication status | Published - 1 Oct 2002 |
Keywords
- endothelium
- Endothelium-derived hyperpolarizing factor
- guanylyl cyclase
- nitric oxide
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Tracey, A., Bunton, D., Irvine, J., MacDonald, A., & Shaw, A. M. (2002). Relaxation to bradykinin in bovine pulmonary supernumerary arteries can be mediated by both a nitric oxide-dependent and -independent mechanism. British Journal of Pharmacology. http://researchonline.gcu.ac.uk/sls/124