Reduced venous compliance and increased transcapillary escape of protein in insulin‐dependent diabetic patients

D. Bell*, A. Collier, J. J. Nicoll, M. Jackson, A. M. Millar, B. F. Clarke, A. L. Muir

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Lower limb venous compliance and transcapillary escape rate of transferrin were measured in eight normotensive, insulin‐dependent male diabetic patients and eight control subjects using a dual isotope technique. Technetium‐99m labelled autologous erythrocytes were used to measure venous compliance and to correct for local changes in blood volume, whilst lndium‐113m labelled transferrin was used to measure trans‐capillary escape of protein. The diabetic patients were found to have reduced venous compliance 1.5 (0.7 to 3.4) × 10−2 mmHg−1 compared with controls 3.2 (2.4 to 4.1) × 10−2 mmHg−1 (p<0.01). The diabetic patients were also found to have greater transcapillary escape of transferrin −2.7 (‐ 1.5 to −5.3) × 10−3, compared with control subjects −5.2 (‐4.1 to −8.1) × 10−3 (p<0.02) in response to increasing hydrostatic pressure. These results show reduced venous compliance in patients with a mean duration of diabetes of 15 years and with only at most, early complications of diabetes, and confirm previous observations showing increased transcapillary escape of protein. 1988 Diabetes UK
Original languageEnglish
Pages (from-to)454-458
Number of pages5
JournalDiabetic Medicine
Volume5
Issue number5
DOIs
Publication statusPublished - Jul 1988
Externally publishedYes

Keywords

  • Diabetes
  • Hydrostatic pressure
  • Transcapillary escape
  • Venous compliance

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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